公开(公告)号：US20210130346A1

公开(公告)日：2021-05-06

申请号：US16605039

申请日：2017-04-14

申请人： AbbVie Inc.

发明人： David Hardee ,  Jason Brewer ,  Lisa Hasvold ,  Dachun Liu ,  Keith McDaniel ,  Michael Schrimpf ,  George Sheppard

IPC分类号： C07D471/04 ,  A61P35/04

摘要： Compounds of formula (I), wherein R1, R2, R3, R5, R6, R7, A1, A2, A3, A4, X1, and X2 have any of the values defined in the specification and pharmaceutically acceptable salts thereof, which are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS are provided. Pharmaceutical compositions comprising of compounds of formula (I) are also provided.

公开(公告)号：US20210179556A1

公开(公告)日：2021-06-17

申请号：US17173613

申请日：2021-02-11

申请人： AbbVie Inc.

发明人： Dominique Bonafoux ,  Heather Michele Davis ,  Kristine E. Frank ,  Michael M. Friedman ,  J. Martin Herold ,  Michael Z. Hoemann ,  Raymond Huntley ,  Augustine Osuma ,  George Sheppard ,  Gagandeep Kaur Somal ,  Jennifer Van Camp ,  Stacy Anne Van Epps ,  Anil Vasudevan ,  Grier Allan Wallace ,  Lu Wang ,  Lu Wang ,  Zhi Wang ,  Noel S. Wilson ,  Xiangdong Xu

IPC分类号： C07D209/08 ,  C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D231/56 ,  C07D401/12 ,  A61P35/00 ,  C07D513/04 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04

摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：US10131657B2

公开(公告)日：2018-11-20

申请号：US14392200

申请日：2014-05-13

申请人： AbbVie Inc.

发明人： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC分类号： A61K31/437 ,  A61K31/454 ,  A61K31/4545 ,  C07D471/04 ,  A61K45/06 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/497 ,  A61K31/506

摘要： The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US20190382383A1

公开(公告)日：2019-12-19

申请号：US16341352

申请日：2016-10-14

申请人： AbbVie Inc.

发明人： Marlon Cowart ,  Steven Fidanze ,  Lisa Hasvold ,  Dachun Liu ,  Keith McDaniel ,  John Pratt ,  George Sheppard ,  Le Wang

IPC分类号： C07D405/12 ,  C07D487/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

摘要： Provided herein are compounds of formula (I) wherein R1, Y, L1, G1, X1, X2, L2, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, which are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20190084981A1

公开(公告)日：2019-03-21

申请号：US16192927

申请日：2018-11-16

申请人： AbbVie Inc.

发明人： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC分类号： C07D471/04 ,  A61K45/06 ,  A61K31/506 ,  A61K31/497 ,  A61K31/437 ,  A61K31/551 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545

摘要： The present invention provides for compounds of formula (I) wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US09567339B2

公开(公告)日：2017-02-14

申请号：US14315504

申请日：2014-06-26

申请人： AbbVie Inc.

发明人： Dominique Bonafoux ,  Heather M. Davis ,  Kristine E. Frank ,  Michael M. Friedman ,  J. Martin Herold ,  Michael Z. Hoemann ,  Raymond Huntley ,  Augustine Osuma ,  George Sheppard ,  Gagandeep K. Somal ,  Jennifer Van Camp ,  Stacy A. Van Epps ,  Anil Vasudevan ,  Grier A. Wallace ,  Lu Wang ,  Lu Wang ,  Zhi Wang ,  Noel S. Wilson ,  Xiangdong Xu

IPC分类号： C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D209/08 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D231/56 ,  C07D401/12

CPC分类号： C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

摘要翻译： 本发明提供式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：US20240360124A1

公开(公告)日：2024-10-31

申请号：US18516230

申请日：2023-11-21

申请人： AbbVie Inc.

发明人： Steven D. Fidanze ,  Lisa A. Hasvold ,  Dachun Liu ,  Keith F. McDaniel ,  John Pratt ,  Michael Schrimpf ,  George Sheppard ,  Le Wang ,  Bing Li

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides for compounds of formula (I)




wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20200255426A1

公开(公告)日：2020-08-13

申请号：US16858930

申请日：2020-04-27

申请人： AbbVie Inc.

发明人： Steven D. Fidanze ,  Lisa A. Hasvold ,  Dachun Liu ,  Keith F. McDaniel ,  John Pratt ,  Michael Schrimpf ,  George Sheppard ,  Le Wang ,  Bing Li

IPC分类号： C07D471/04

摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20190284135A1

公开(公告)日：2019-09-19

申请号：US16421006

申请日：2019-05-23

申请人： AbbVie Inc.

发明人： Dominique Bonafoux ,  Heather Michele Davis ,  Kristine E. Frank ,  Michael M. Friedman ,  J. Martin Herold ,  Michael Z. Hoemann ,  Raymond Huntley ,  Augustine Osuma ,  George Sheppard ,  Gagandeep Kaur Somal ,  Jennifer Van Camp ,  Stacy Anne Van Epps ,  Anil Vasudevan ,  Grier Allan Wallace ,  Lu Wang ,  Lu Wang ,  Zhi Wang ,  Noel S. Wilson ,  Xiangdong Xu

IPC分类号： C07D209/08 ,  C07D487/04 ,  C07D405/14 ,  C07D231/56 ,  C07D403/14 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D417/12 ,  A61P35/00 ,  C07D513/04 ,  C07D209/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D209/10 ,  C07D209/12 ,  C07D413/04 ,  C07D209/18 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D401/12

摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：US20160185769A1

公开(公告)日：2016-06-30

申请号：US14392200

申请日：2014-05-13

申请人： ABBVIE INC.

发明人： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC分类号： C07D471/04 ,  A61K31/541 ,  A61K31/496 ,  A61K31/551 ,  A61K31/437 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06

摘要： The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

摘要翻译： 本发明提供式（I）化合物。 其中Rx，Ry，Rx1，L1，G1，A1，A2，A3和A4具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎症 疾病，癌症和艾滋病。 还提供了由一种或多种式（I）化合物组成的药物组合物。