公开(公告)号：US5591434A

公开(公告)日：1997-01-07

申请号：US229393

申请日：1994-04-15

申请人： Mark C. Jenkins ,  Ronald Fayer ,  Michael Tilley ,  Steven L. Upton

发明人： Mark C. Jenkins ,  Ronald Fayer ,  Michael Tilley ,  Steven L. Upton

IPC分类号： A61K39/00 ,  C07K14/44 ,  C07K16/04 ,  C07K16/20 ,  A61K39/002 ,  A61K39/395 ,  C12N15/30 ,  C12N1/21 ,  C12P21/02 ,  C12P21/08

CPC分类号： C07K16/04 ,  C07K14/44 ,  C07K16/20 ,  A61K39/00

摘要： Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The Proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

摘要翻译： 已经开发了用于免疫动物以防止隐孢子虫病的重组蛋白质。 蛋白质可有效地免疫多种动物对小隐孢子虫，特别是用于生产可用于赋予对寄生虫的被动免疫的超免疫初乳。 已经开发了编码这些蛋白质的分离的DNA序列。 可以将DNA序列插入到重组DNA分子中，例如用于转化细胞和产生蛋白质的克隆载体或表达载体。

公开(公告)号：US06521229B1

公开(公告)日：2003-02-18

申请号：US09888655

申请日：2001-06-26

申请人： Mark C. Jenkins ,  Ronald Fayer ,  James Trout

发明人： Mark C. Jenkins ,  Ronald Fayer ,  James Trout

IPC分类号： A61K39395

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K2319/00 ,  Y02A50/488 ,  Y02A50/489

摘要： Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

摘要翻译： 已经开发了用于免疫动物以防止隐孢子虫病的重组蛋白质。 这些蛋白质可以有效地免疫多种动物对小隐孢子虫，特别是用于生产可能被用于赋予对寄生虫的被动免疫的超免疫初乳。 已经开发了编码这些蛋白质的分离的DNA序列。 可以将DNA序列插入到重组DNA分子中，例如用于转化细胞和产生蛋白质的克隆载体或表达载体。