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    Use of Genetically Modified Organisms to Generate Biomass Degrading Enzymes
    1.
    发明申请
    Use of Genetically Modified Organisms to Generate Biomass Degrading Enzymes 有权
    使用转基因生物生物降解酶

    公开(公告)号：US20120107853A1

    公开(公告)日：2012-05-03

    申请号：US13269414

    申请日：2011-10-07

    申请人： Stephen Mayfield ,  Bryan O'Neill ,  Michael Mendez ,  Yan Poon

    发明人： Stephen Mayfield ,  Bryan O'Neill ,  Michael Mendez ,  Yan Poon

    IPC分类号： C12Q1/34

    CPC分类号： C12Q1/6895 ,  C12N15/8214 ,  Y02E50/16

    摘要： The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol.

    摘要翻译： 本发明提供了一种用于高通量筛选用于等离子体状态的遗传修饰的光合生物的方法和组合物。 本发明提供了在植物中产生一种或多种蛋白质，包括生物降解酶的方法。 还提供了在藻细胞，特别是在叶绿体中生产生物质降解途径的方法。 可以通过所公开的方法产生单一酶或多种酶。 本文公开的方法允许生产生物燃料，包括乙醇。

    VARIANT ISOPRENOID PRODUCING ENZYMES AND USES THEREOF
    2.
    发明申请
    VARIANT ISOPRENOID PRODUCING ENZYMES AND USES THEREOF 有权
    各种异辛烯生产酶及其用途

    公开(公告)号：US20120064629A1

    公开(公告)日：2012-03-15

    申请号：US13260696

    申请日：2010-03-29

    申请人： Michael Mendez ,  Craig A. Behnke ,  Nicole A. Heaps

    发明人： Michael Mendez ,  Craig A. Behnke ,  Nicole A. Heaps

    IPC分类号： C12N5/10 ,  C12N15/63 ,  C12N1/19 ,  C12N1/13 ,  C07H21/00 ,  C12N1/21

    CPC分类号： C12P9/00 ,  C12N9/1085 ,  C12N9/88

    摘要： This disclosure provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present disclosure provides methods of generating polypeptide variants, for example, variant isoprenoid synthases and/or variant prenyl transferases that have at least one desired property not present in the parent polypeptide. The present disclosure further provides polypeptides and polynucleotides encoding variant polypeptides, as well as vectors and host cells comprising the polynucleotides that encode the variant polypeptides. In other embodiments, the present disclosure provides methods of using the variant polypeptides to generate useful products, such as isoprenoid compounds and/or isoprenoid products.

    摘要翻译： 本公开提供了设计和产生与亲本多肽相比具有改变的性质的多肽变体的方法。 本公开提供了产生多肽变体的方法，例如变体类异戊二烯合酶和/或变体异戊烯基转移酶，其具有在母体多肽中不存在的至少一种所需性质。 本发明还提供编码变体多肽的多肽和多核苷酸，以及包含编码变体多肽的多核苷酸的载体和宿主细胞。 在其它实施方案中，本公开提供使用变体多肽产生有用产物的方法，例如类异戊二烯化合物和/或类异戊二烯产品。

    STRESS-INDUCED LIPID TRIGGER
    5.
    发明申请
    STRESS-INDUCED LIPID TRIGGER 有权
    应力诱导脂质触发器

    公开(公告)号：US20120322157A1

    公开(公告)日：2012-12-20

    申请号：US13576821

    申请日：2011-02-01

    申请人： Christopher Yohn ,  April Brand ,  Michael Mendez ,  Craig A. Behnke

    发明人： Christopher Yohn ,  April Brand ,  Michael Mendez ,  Craig A. Behnke

    IPC分类号： C12N1/13 ,  C12N15/63

    CPC分类号： C12P7/6463 ,  C07K14/405 ,  C12N15/8247 ,  C12P7/6409

    摘要： The present disclosure provides novel proteins that when over expressed in algae result in an increase or change in fatty acid and/or glycerol lipid production and/or accumulation, without a substantial decrease in the growth rate of the alga or the break down of algal components, such as chlorophyll. The present disclosure also describes methods of using the novel proteins to increase or change the production and/or accumulation of fatty acids and/or glycerol lipids in algae. In addition, these proteins are useful tools in obtaining information about the fatty acid and triacyglyceride (TAG) synthetic pathways in algae.

    摘要翻译： 本公开提供了当藻类中过度表达导致脂肪酸和/或甘油脂质生成和/或积累的增加或改变而不显着降低藻类生长速率或藻类成分分解时的新型蛋白质 ，如叶绿素。 本公开还描述了使用新型蛋白质来增加或改变藻类中脂肪酸和/或甘油脂质的产生和/或积累的方法。 此外，这些蛋白质是获得关于藻类中的脂肪酸和三酰甘油（TAG）合成途径的信息的有用工具。

    Use of genetically modified organisms to generate biomass degrading enzymes
    7.
    发明授权
    Use of genetically modified organisms to generate biomass degrading enzymes 有权
    使用转基因生物来生成生物降解酶

    公开(公告)号：US08318436B2

    公开(公告)日：2012-11-27

    申请号：US13269414

    申请日：2011-10-07

    申请人： Stephen Mayfield ,  Bryan O'Neill ,  Michael Mendez ,  Yan Poon

    发明人： Stephen Mayfield ,  Bryan O'Neill ,  Michael Mendez ,  Yan Poon

    IPC分类号： C12Q1/68 ,  C12Q1/34 ,  C12P19/30 ,  C12N15/64 ,  C12N9/42 ,  C12N1/00 ,  C12N1/12 ,  C07H21/02 ,  C07H19/04

    CPC分类号： C12Q1/6895 ,  C12N15/8214 ,  Y02E50/16

    摘要： The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol.

    摘要翻译： 本发明提供了一种用于高通量筛选用于等离子体状态的遗传修饰的光合生物的方法和组合物。 本发明提供了在植物中产生一种或多种蛋白质，包括生物降解酶的方法。 还提供了在藻细胞，特别是在叶绿体中生产生物质降解途径的方法。 可以通过所公开的方法产生单一酶或多种酶。 本文公开的方法允许生产生物燃料，包括乙醇。

    Transformation of algae for increasing lipid production
    8.
    发明授权
    Transformation of algae for increasing lipid production 有权
    转化藻类以增加脂质生产

    公开(公告)号：US09428779B2

    公开(公告)日：2016-08-30

    申请号：US13576821

    申请日：2011-02-01

    申请人： Christopher Yohn ,  April Brand ,  Michael Mendez ,  Craig A. Behnke

    发明人： Christopher Yohn ,  April Brand ,  Michael Mendez ,  Craig A. Behnke

    IPC分类号： C12P7/64 ,  C07K14/405 ,  C12N15/82

    CPC分类号： C12P7/6463 ,  C07K14/405 ,  C12N15/8247 ,  C12P7/6409

    摘要： The present disclosure provides novel proteins that when over expressed in algae result in an increase or change in fatty acid and/or glycerol lipid production and/or accumulation, without a substantial decrease in the growth rate of the alga or the break down of algal components, such as chlorophyll. The present disclosure also describes methods of using the novel proteins to increase or change the production and/or accumulation of fatty acids and/or glycerol lipids in algae. In addition, these proteins are useful tools in obtaining information about the fatty acid and triacyglyceride (TAG) synthetic pathways in algae.

    摘要翻译： 本公开提供了当藻类中过度表达导致脂肪酸和/或甘油脂质生成和/或积累的增加或改变而不显着降低藻类生长速率或藻类成分分解时的新型蛋白质 ，如叶绿素。 本公开还描述了使用新型蛋白质来增加或改变藻类中脂肪酸和/或甘油脂质的产生和/或积累的方法。 此外，这些蛋白质是获得关于藻类中的脂肪酸和三酰甘油（TAG）合成途径的信息的有用工具。