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1.发明授权Substituted pyrimido 4.5-d pyrimidin-4-one compounds for modulating TRPV3 function 有权用于调节TRPV3功能的取代的嘧啶基4.5-d嘧啶-4-酮化合物公开(公告)号：US08552009B2
公开(公告)日：2013-10-08
申请号：US13022107
申请日：2011-02-07
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, Jr. , Magdalene M. Moran , Amy S. Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, Jr. , Magdalene M. Moran , Amy S. Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
IPC分类号： A61K31/519
CPC分类号： C07D487/04 , A61K31/517 , C07D239/91 , C07D401/06 , C07D471/04
摘要： The present application relates to compounds of Formula I as defined herein, and methods for treating pain and other conditions related to TRPV3.
摘要翻译： 本申请涉及本文定义的式I化合物，以及用于治疗与TRPV3有关的疼痛和其它病症的方法。
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公开(公告)号：US08541423B2
公开(公告)日：2013-09-24
申请号：US13444213
申请日：2012-04-11
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
IPC分类号： A61P29/00 , A61K31/522 , A61K31/513 , C07D239/06
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译： 本申请涉及治疗疼痛，失禁等条件的化合物和方法。
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3.发明授权Compounds and compositions for treating chemical warfare agent-induced injuries 有权用于治疗化学战剂诱发的伤害的化合物和组合物公开(公告)号：US08318728B2
公开(公告)日：2012-11-27
申请号：US12466187
申请日：2009-05-14
申请人： Jayhong A. Chong
发明人： Jayhong A. Chong
IPC分类号： A61K31/54
CPC分类号： A61K31/522 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0053 , A61K31/4188 , A61K31/4985 , A61K31/519 , C07D471/04 , C07D473/30 , C07D487/04
摘要： Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
摘要翻译： 本文描述了用于治疗由化学战剂引起的伤害的化合物和组合物。
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4.发明授权Methods of using voltage-gated Hv1 proton channels to detect changes in intracellular pH 有权使用电压门控Hv1质子通道检测细胞内pH变化的方法公开(公告)号：US09068018B2
公开(公告)日：2015-06-30
申请号：US12279436
申请日：2007-02-15
IPC分类号： G01N33/567 , G01N33/53 , G01N33/569 , G01N33/554 , C12N1/20 , C12N1/00 , C12N5/00 , C12N5/02 , C12N5/07 , C12N5/10 , C07K14/705 , G01N33/68
CPC分类号： C07K14/705 , G01N33/6872
摘要： Nucleic acid and protein sequences relating to a proton channel (Hv1) are disclosed. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the Hv1 gene and protein are disclosed. Also provided are methods of identifying modulators of Hv1 activity, methods of geno typing subjects with respect to Hv1, and methods of diagnosing and treating Hv1-mediated disorders.
摘要翻译： 公开了与质子通道（Hv1）相关的核酸和蛋白质序列。 公开了核酸，载体，转化细胞，转基因动物，多肽和与Hv1基因和蛋白相关的抗体。 还提供了鉴定Hv1活性的调节剂的方法，关于Hv1的基因分型受试者的方法，以及诊断和治疗Hv1介导的病症的方法。
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公开(公告)号：US20130123283A1
公开(公告)日：2013-05-16
申请号：US13444213
申请日：2012-04-11
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mendel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mendel-Brehm
IPC分类号： C07D473/08
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译： 本申请涉及治疗疼痛，失禁等条件的化合物和方法。
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公开(公告)号：US08137918B2
公开(公告)日：2012-03-20
申请号：US12244630
申请日：2008-10-02
CPC分类号： A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2227/106 , A01K2267/03 , C07K14/47 , C07K14/705 , C12Q1/6881 , C12Q2600/158 , G01N33/5014 , G01N33/5023 , G01N33/5044 , G01N2500/04 , G01N2800/367
摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.
摘要翻译： 公开了与精子特异性的阳离子通道相关的核酸和蛋白质序列（CatSper4）。 显示CatSper4蛋白在精子中特异性表达。 公开了与CatSper4基因和蛋白相关的核酸，载体，转化细胞，转基因动物，多肽和抗体。 还提供了体外受精和避孕方法，鉴定CatSper4活性的调节剂的方法，关于CatSper4的受试者的基因分型方法，以及诊断和治疗CatSper4介导的疾病（包括不育症）的方法。 还公开了相关业务方法。
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公开(公告)号：US08110668B2
公开(公告)日：2012-02-07
申请号：US10523479
申请日：2003-08-04
CPC分类号： A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A61K38/00 , C07K14/705 , C12Q1/025 , C12Q1/6883 , C12Q2600/156 , G01N33/5014 , G01N33/5044
摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.
摘要翻译： 公开了与精子特异性的阳离子通道相关的核酸和蛋白质序列（CatSper3）。 显示CatSper3蛋白在精子中特异性表达。 公开了与CatSper3基因和蛋白相关的核酸，载体，转化细胞，转基因动物，多肽和抗体。 还提供了体外受精和避孕方法，鉴定CatSper3活性调节剂的方法，关于CatSper3的受试者基因分型方法，以及诊断和治疗CatSper3介导的疾病包括不孕症的方法。 还公开了相关业务方法。
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公开(公告)号：US20120015979A1
公开(公告)日：2012-01-19
申请号：US13175366
申请日：2011-07-01
申请人： Magdalene M. Moran , Jayhong A. Chong , Christopher Fanger , Amy Ripka , Glenn R. Larsen , Xiaoguang Zhen , Dennis John Underwood , Manfred Weigele
发明人： Magdalene M. Moran , Jayhong A. Chong , Christopher Fanger , Amy Ripka , Glenn R. Larsen , Xiaoguang Zhen , Dennis John Underwood , Manfred Weigele
IPC分类号： A61K31/4709 , A61P17/02 , A61P29/00 , A61P3/10 , A61P17/06 , A61P17/00 , A61P25/06 , A61P1/00 , A61P37/00 , A61P19/02 , A61P11/14 , A61Q7/02 , A61P17/10 , A61Q19/08 , A61P35/00 , A61P31/10 , A61P31/12 , A61P31/00 , A61P17/12 , A61P25/00
CPC分类号： A61K31/4709 , C07D401/12
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
摘要翻译： 本申请涉及用于治疗与TRPV3相关的疼痛和其它病症的化合物和方法。
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公开(公告)号：US07671061B2
公开(公告)日：2010-03-02
申请号：US11645307
申请日：2006-12-22
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen Mcnamara , Xiaoguang Zhen , Josh Mandel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen Mcnamara , Xiaoguang Zhen , Josh Mandel-Brehm
IPC分类号： A61K31/522 , A61K31/513
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译： 本申请涉及治疗疼痛，失禁等条件的化合物和方法。
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公开(公告)号：US09486455B2
公开(公告)日：2016-11-08
申请号：US13040859
申请日：2011-03-04
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号： A01N43/58 , A01N43/60 , A61K31/517 , A61K31/519
CPC分类号： A61K31/519 , A61K31/517
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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