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公开(公告)号:US08754039B2
公开(公告)日:2014-06-17
申请号:US12683160
申请日:2010-01-06
申请人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
发明人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
摘要翻译: 本发明提供了新颖的靶向抗微生物组合物。 在各种实施方案中,提供了包含与结合细菌菌株或物种的肽靶向部分连接的抗微生物肽的嵌合部分。
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公开(公告)号:US20110039761A1
公开(公告)日:2011-02-17
申请号:US12683160
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
摘要翻译: 本发明提供了新颖的靶向抗微生物组合物。 在各种实施方案中,提供了包含与结合细菌菌株或物种的肽靶向部分连接的抗微生物肽的嵌合部分。
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公开(公告)号:US08889156B2
公开(公告)日:2014-11-18
申请号:US12700163
申请日:2010-02-04
CPC分类号: A61K38/16 , A61K8/64 , A61K38/08 , A61K38/10 , A61K49/0002 , A61Q3/00 , A61Q7/00 , A61Q11/00
摘要: This invention provides novel methods for inducing hair growth and/or inhibiting hair loss and/or inducing nail growth in a mammal. In various embodiments the methods involve administering, e.g., to a mammal in need thereof, a calcium-binding peptide and/or peptide-like moiety in an amount sufficient to induce hair growth and/or to inhibit hair loss. In certain embodiments the agent is topically and/or transdermally administered.
摘要翻译: 本发明提供了用于在哺乳动物中诱导毛发生长和/或抑制脱发和/或诱导指甲生长的新方法。 在各种实施方案中,所述方法包括以足以诱导毛发生长和/或抑制脱发的量向例如需要的哺乳动物施用钙结合肽和/或肽样部分。 在某些实施方案中,所述试剂是局部和/或经皮施用的。
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4.
公开(公告)号:US20120003661A1
公开(公告)日:2012-01-05
申请号:US13170045
申请日:2011-06-27
申请人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
发明人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
IPC分类号: C12Q1/68 , C12M1/34 , C12Q1/66 , C12Q1/40 , C12Q1/32 , G01N27/26 , C12Q1/42 , C12Q1/26 , C12Q1/04 , C12Q1/34 , C12Q1/44 , C12Q1/06 , G01N33/569 , C12Q1/48
摘要: Methods and devices are provided for the rapid and specific detection of target microorganisms, cells, and the like. In one embodiment, the methods involve contacting a target microorganism (e.g., in a sample) with a permeabilization reagent that selectively permeabilizes or lyses the microorganism; contacting the selectively permeabilized microorganism with a detection reagent that is taken into the selectively permeabilized organism or that contacts metabolites or enzymes released by the selectively permeabilized microorganism, where the detection reagent produces a signal in the presence of said metabolites or enzymes; and detecting a signal produced by the detection reagent in the presence of the metabolites or enzymes wherein the strength of the signal indicates the presence and/or amount of the target microorganism in the sample.
摘要翻译: 提供了用于快速和具体检测靶微生物,细胞等的方法和装置。 在一个实施方案中,所述方法包括使靶微生物(例如,样品)与选择性渗透或裂解微生物的透化试剂接触; 使选择性透过的微生物与被选入透化生物体中的检测试剂接触或接触由选择性透化的微生物释放的代谢物或酶,其中所述检测试剂在所述代谢物或酶存在下产生信号; 以及在所述代谢物或酶的存在下检测由所述检测试剂产生的信号,其中所述信号的强度表示样品中目标微生物的存在和/或量。
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公开(公告)号:US20110039763A1
公开(公告)日:2011-02-17
申请号:US12683352
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
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公开(公告)号:US20100184684A1
公开(公告)日:2010-07-22
申请号:US12683286
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
IPC分类号: A61K38/16 , C07K14/00 , C07K7/08 , C07K7/06 , A61K38/10 , A01N37/18 , A61K38/08 , C07K16/00 , A61P31/04 , A61P31/10 , A01P1/00
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
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公开(公告)号:US20100184681A1
公开(公告)日:2010-07-22
申请号:US12683188
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
IPC分类号: A61K38/16 , C07K14/00 , C07K7/08 , C07K7/06 , A01N37/18 , A61K38/10 , A61K38/08 , C07K16/00 , A61P31/04 , A61P31/10 , A01P1/00
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
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公开(公告)号:US20080170991A1
公开(公告)日:2008-07-17
申请号:US11851372
申请日:2007-09-06
申请人: Wenyuan Shi , Randal H. Eckert , Daniel K. Yarbrough , Fengxia Qi , Jian He , Ian H. McHardy , Maxwell H. Anderson
发明人: Wenyuan Shi , Randal H. Eckert , Daniel K. Yarbrough , Fengxia Qi , Jian He , Ian H. McHardy , Maxwell H. Anderson
CPC分类号: A61K38/10 , A01N37/18 , A01N37/46 , A61K38/00 , A61K38/1709 , A61K47/65 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/315 , C07K2319/01
摘要: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.
摘要翻译: 本发明涉及能够特异性结合微生物(例如铜绿假单胞菌或变形链球菌)的靶向肽,具有抗微生物活性的抗微生物肽以及具体/选择性靶向的抗微生物肽(STAMP)。 此外,本发明提供了通过使用本发明提供的肽或组合物选择性杀死或抑制微生物生物的方法。
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公开(公告)号:US08680058B2
公开(公告)日:2014-03-25
申请号:US12938278
申请日:2010-11-02
申请人: Randal H. Eckert , Daniel K. Yarbrough , Wenyuan Shi , Maxwell H. Anderson , Fengxia Qi , Jian He , Ian H. McHardy
发明人: Randal H. Eckert , Daniel K. Yarbrough , Wenyuan Shi , Maxwell H. Anderson , Fengxia Qi , Jian He , Ian H. McHardy
CPC分类号: A61K38/10 , A01N37/18 , A01N37/46 , A61K38/00 , A61K38/1709 , A61K47/65 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/315 , C07K2319/01
摘要: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.
摘要翻译: 本发明涉及能够特异性结合微生物(例如铜绿假单胞菌或变形链球菌)的靶向肽,具有抗微生物活性的抗微生物肽以及特异性/选择性靶向的抗微生物肽(STAMP)。 此外,本发明提供了通过使用本发明提供的肽或组合物选择性杀死或抑制微生物生物的方法。
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公开(公告)号:US08303962B2
公开(公告)日:2012-11-06
申请号:US12683188
申请日:2010-01-06
申请人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
发明人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
IPC分类号: A61K38/00 , A61K38/04 , A61K39/00 , A61K39/02 , A61K39/09 , A61K39/38 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
摘要翻译: 本发明提供了新的抗微生物肽及其制剂。 肽和/或制剂有效杀死或抑制各种细菌,酵母和真菌的生长和/或增殖。
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