摘要:
The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and/or pneumococcal diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
摘要:
The present invention relates to the field of applied and environmental microorganism and agriculture. Disclosed are a thifensulfuron hydrolase gene tsmE and uses thereof. The thifensulfuron hydrolase gene tsmE has a nucleotide sequence of SEQ ID NO. 1, full length of 1194 bp, and G+C content of 51.09%, and encodes 398 amino acids with an amino acid sequence of SEQ ID NO. 2. The thifensulfuron hydrolase TsmE provided by the present invention can degrade completely 100 mg/L thifensulfuron within 1 hour into the herbicidally inactive product thiophenesulfonic acid; in addition, the TsmE also degrade completely 100 mg/L haloxyfop-R-methyl within 1 hour. Therefore, the thifensulfuron hydrolase gene tsmE is useful in construction of thifensulfuron-resistant transgenic crops and bioremediation of thifensulfuron or haloxyfop-R-methyl-contaminated environments.
摘要:
A pharmaceutical composition comprises 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol, and can be used to prepare the medicine for treating cerebrovascular diseases.
摘要:
The present invention provides a method and device for allocating uplink shared channel resource, and a communication system, for solving the problem of the overall performance of the communication system being reduced in an existing allocating method. The method comprises: acquiring the volume of data-to-be-transmitted and an uplink channel quality indication; on the basis of the volume of data-to-be-transmitted acquired, determining at least one set of resource profile of the uplink channel quality indication and a resource number; judging of whether or not the uplink channel quality indication comprised within the at least one set of resource profile is identical to the uplink channel quality indication acquired, if identical, using a corresponding set of resource profile as a final resource profile; and if different, combining an uplink transmission power with the corresponding set of resource profile to determine the final resource profile. Under the premise of ensuring QoS, the present invention allows for minimization of transmission power of each terminal, thus reducing inter-system interference, allowing system performance to be further improved.
摘要:
Methods and devices are provided for the rapid and specific detection of target microorganisms, cells, and the like. In one embodiment, the methods involve contacting a target microorganism (e.g., in a sample) with a permeabilization reagent that selectively permeabilizes or lyses the microorganism; contacting the selectively permeabilized microorganism with a detection reagent that is taken into the selectively permeabilized organism or that contacts metabolites or enzymes released by the selectively permeabilized microorganism, where the detection reagent produces a signal in the presence of said metabolites or enzymes; and detecting a signal produced by the detection reagent in the presence of the metabolites or enzymes wherein the strength of the signal indicates the presence and/or amount of the target microorganism in the sample.
摘要:
The invention discloses a LED lamp, including: a lamp body has illuminating surface and reflective panel, wherein the reflective panel reflects light then transmits by illuminating surface, both sides of reflective panel have axial strip-shaped notch while both ends of lamp body have lamp holder; two LED luminous components, cooperatively installed inside the strip-shaped notch of lamp body and the illuminating surface turns to reflective panel; a drive circuit installed inside lamp holder, and electrically connects with luminous components and illuminates LED luminous components. The light from LED light source of the invention transmits from illuminating surface after the diffuse reflection from reflective panel and multiple refractions from solid lamp body, increasing light-emitting area, and lights are bright, mild and even; with effectual lighting, lower power consumption, longer life-span and good for eyes, the invention is applicable widely to house, office, market, carriage with great economic and social benefit.
摘要:
This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against Streptococcus mutans a common oral pathogen and the causative agent of dental caries.
摘要:
This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
摘要:
A pharmaceutical composition comprises 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol, and can be used to prepare the medicine for treating cerebrovascular diseases.
摘要:
This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.