发明授权
US08512973B2 Methods of using engineered ketoreductase polypeptides for the stereoselective reduction of acetophenones
有权
使用工程化酮还原酶多肽进行苯乙酮立体选择性还原的方法
- 专利标题： Methods of using engineered ketoreductase polypeptides for the stereoselective reduction of acetophenones
- 专利标题（中）： 使用工程化酮还原酶多肽进行苯乙酮立体选择性还原的方法
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申请号： US13682600申请日： 2012-11-20
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公开(公告)号： US08512973B2公开(公告)日： 2013-08-20
- 发明人: Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
- 申请人： Codexis, Inc.
- 申请人地址： US CA Redwood City US NY New York
- 专利权人： Codexis, Inc.,Pfizer, Inc.
- 当前专利权人： Codexis, Inc.,Pfizer, Inc.
- 当前专利权人地址： US CA Redwood City US NY New York
- 代理机构： Codexis, Inc.
- 主分类号： C12Q1/26
- IPC分类号： C12Q1/26 ; C12P7/02 ; C07K14/00 ; C12N9/02 ; C12P21/00
摘要：
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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