- 专利标题： KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE
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申请号： US16445768申请日： 2019-06-19
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公开(公告)号： US20200095214A1公开(公告)日： 2020-03-26
- 发明人: John M. MCCALL , Hugh Y. RIENHOFF, Jr. , Michael CLARE
- 申请人： Imago Biosciences, Inc.
- 主分类号： C07D295/192
- IPC分类号： C07D295/192 ; C07C237/22 ; C07D213/81 ; C07D233/90 ; C07D295/185 ; C07D295/26 ; A61K31/166 ; A61K31/40 ; A61K31/4453 ; A61K31/454 ; A61K31/4545 ; A61K31/47 ; A61K31/495 ; A61K31/5375 ; A61K31/54 ; C07D215/14
摘要：
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
公开/授权文献
- US10882835B2 KDM1A inhibitors for the treatment of disease 公开/授权日：2021-01-05
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