The invention relates to an electro-mechanical brake with an actuator (5) for pressing at least one brake pad (3, 4) against a rotating friction surface. The actuator (5) comprises an electric motor (7) and a first transmission for converting a rotary motion of the electric motor (7) into a translational motion of the at least one brake pad (3, 4) for activating or releasing the electromechanical brake. Furthermore, the actuator (5) comprises a second transmission for converting a rotary motion of the same electric motor (7) into a further translational motion of the at least one brake pad (3, 4) to compensate for a wear of the at least one brake pad (3, 4), the first transmission and the second transmission being coupled so that the translational motion of the at least one brake pad (3, 4) caused by the first transmission and the further translational motion of the at least one brake pad (3, 4) caused by the second transmission add up to a resulting translation of the at least one brake pad (3, 4).