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CN110547459A 一种采用冷冻干燥制备固体十八烷酰十八烷酸普鲁兰多糖酯载油纳米粒子的方法 审中-实审

一种采用冷冻干燥制备固体十八烷酰十八烷酸普鲁兰多糖酯载油纳米粒子的方法
摘要：
一种采用冷冻干燥制备固体十八烷酰十八烷酸普鲁兰多糖酯载油纳米粒子的方法，属于载油固体纳米粒子制备领域。一种采用冷冻干燥制备固体十八烷酰十八烷酸普鲁兰多糖酯载油纳米粒子的方法，包括以下步骤：（1）溶胀：将十八烷酰十八烷酸普鲁兰多糖酯加入水中，十八烷酰十八烷酸普鲁兰多糖酯与水的质量比为1:10~20，溶胀4~6h；（2）混合：将油和海藻糖与步骤（1）中液体混合，得到混合液；（3）高速搅拌分散：将步骤（2）中所得混合液用高速搅拌分散机搅拌30min，得到分散液；（4）高压均质：将步骤（3）中分散液加入高压均质机进行高压均质，直到均匀；（5）冷冻干燥。
摘要（英）：

A method for preparing oil-loading nanoparticles of solid octadecanoyl octadecanoate pullulan polysaccharide ester by freeze-drying belongs to the field of preparing oil-loading solid nanoparticles. The method for preparing oil-loading nanoparticles of solid octadecanoyl octadecanoate pullulan polysaccharide ester by freeze-drying comprises the following steps: (1) swelling: adding octadecanoyl octadecanoate pullulan polysaccharide ester to water, the mass ratio of octadecanoyl octadecanoate pullulan polysaccharide ester to water being 1: 10-20, and conducting swelling for 4-6 hours; (2) mixing: mixing oil and trehalose with the liquid in step (1) to obtain a mixed liquid; (3) high-speed mixing and dispersion: stirring the mixed liquid obtained in step (2) for 30 minutes with a high-speedstirring and dispersion machine to obtain a dispersion liquid; (4) high-pressure homogenization: adding the dispersion liquid in step (3) to a high-pressure homogenizing machine and conducting high-pressure homogenization until the dispersion liquid is even; and (5) freeze drying.

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