The invention discloses a three-coordinate measurement method and device for clamp block type parts. The device comprises a bottom plate, a measurement reference block, a measurement reference hole, a measurement reference surface, a left clamp, a right clamp, a left pressure head, a right pressure head, a clamp block disposing step surface, a clamp block disposing arc surface and a column block, wherein the bottom plate and the measurement reference block are connected through an inside hexagonal bolt, the top surface of the measurement reference block is provided with the measurement reference surface, the measurement reference surface is provided with the measurement reference hole, the bottom plate and the column block are connected through an inside hexagonal bolt, the left clamp and the right clamp are connected with the column block through an inside hexagonal bolt, the left clamp is provided with the left pressure head, the right clamp is provided with the right pressure head, the top surface of the column block is provided with the clamp block disposing step surface and the clamp block disposing arc surface, and the clamp block disposing step surface is connected with one end of the clamp block disposing arc surface. The device is advantaged in that measurement reliability is guaranteed under the condition of a single product and small-batch production, the mounting, fixing and measurement time is shortened, detection efficiency is improved, and cost is substantially reduced.