The invention discloses a centralized control circuit of a sliding plug door of a rail vehicle. A motor car is provided with a left side car end connector and a right side car end connector; a left side car end connector and a right side car end connector are arranged at both the head and tail ends of a trailer; the left side car end connector and right side car end connector of the motor car are respectively connected with the corresponding left side car end connector and right side car end connector of the trailer through jumper wires; the left side car end connector and right side car end connector of the trailer are connected with the left side car end connector and right side car end connector of another trailer connected with the trailer through jumper wires; control trunks for opening left and right doors are laid on a plurality of the trailers, and the centralized control circuit comprises buttons for opening the left and right doors; the buttons for opening the left and right doors are respectively connected to the left and right side car end connectors of the motor car through the control trunks for opening the left and right doors; and the car end connectors between the motor car and each trailer as well as between one trailer and another trailer adopt the jumper wire design. According to the centralized control circuit of the sliding plug door of the rail vehicle, the problem of centralized control of the sliding plug door under a condition of augment, downsizing or free marshalling of a train can be solved, and interchange of the car end jumper wires is completely realized.