The invention discloses a processing process of a difficult-to-deform high temperature alloy GH141 cold-drawn material. On one hand, the structure of a cold-drawing blank and the ratio of cold drawing decrease section are controlled and the internal stress of a rod obtained after cold drawing is reduced by use of a special process; on the other hand, excellent usability is obtained by use of a reasonable thermal treatment process. The adopted technical scheme is as follows: 1, the internal structure of the cold-drawing blank is controlled; 2, softening annealing treatment is adopted; 3, a reasonable ratio of cold drawing decrease section is selected; 4, two different straightening processes are adopted after cold drawing; 5, a reasonable thermal treatment process is selected. The processing process of the difficult-to-deform high temperature alloy GH141 cold-drawn material has the advantages that the structure of the blank is controlled to be uniform, the grain is fine and the crack formation trend can be effectively reduced, the hardness of the cold-drawing blank is reduced by virtue of softening annealing, the internal stress of the rod obtained after cold drawing is reduced effectively by virtue of straightening, and due to the adopted reasonable heat treatment process, at a room temperature, the plastic percentage elongation after fracture of the cold-drawn rod is 25% and the percentage reduction of area is 22%, at 760 DEG C, the high temperature tensile plastic percentage elongation after fracture of the cold-drawn rod is 34% and the percentage reduction of area is 36%; in short, the difficult-to-deform high temperature alloy GH141 cold-drawn material is excellent in properties.