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    Methods and Kits for Ribonuclease Detection
    7.
    发明申请
    Methods and Kits for Ribonuclease Detection 有权

    公开(公告)号：US20240418721A1

    公开(公告)日：2024-12-19

    申请号：US18742862

    申请日：2024-06-13

    Applicant: Lance Philip Ford ,  Joseph Francis Krebs

    Inventor： Lance Philip Ford ,  Joseph Francis Krebs

    IPC: G01N33/573 ,  G01N33/543

    Abstract: A method for detecting ribonucleases uses a reagent fluid containing ribonucleic acid (RNA) tagged with two different affinity tags which is suspended in a buffered solution with a block copolymer surfactant. A plurality of detectable nanoparticles are coated with a receptor that can bind to one of the two affinity tags but not both. A test strip featuring a test line with receptors capable of binding one of the two affinity tags is provided. During the test, a sample containing ribonuclease is mixed with the reagent fluid and the running buffer. As the mixture travels along the strip, it reaches the test line where the nanoparticles are expected to bind. However, ribonuclease reduces this binding, therefore indicating the presence of the enzyme in the sample. This method provides a visual indication of ribonuclease activity based on the interaction and binding patterns of the nanoparticles on the test strip.

    ANTI-EPHA4 ANTIBODY
    8.
    发明申请
    ANTI-EPHA4 ANTIBODY 有权

    公开(公告)号：US20240385190A1

    公开(公告)日：2024-11-21

    申请号：US18704106

    申请日：2022-11-09

    Applicant: EISAI R&D MANAGEMENT CO., LTD.

    Inventor： Tomomi Kawakatsu ,  Kazuhiro Tahara ,  Kazuyoshi Shuta

    IPC: G01N33/573 ,  C07K16/28 ,  G01N33/68

    Abstract: [Problem] To provide an antibody that can bind specifically to EphA4 and detect EphA4 at high detection sensitivity, and a method and a kit for detecting or quantifying EphA4 characterized by the antibody.
    [Solution] Provided are an antibody having a specific heavy chain CDR sequence and light chain CDR sequence and an antigen binding fragment thereof, and a method and kit characterized by the same. Specifically, an antibody according to the present invention or an antigen-binding fragment thereof includes (a) a heavy chain including a heavy chain CDR1 comprising an amino acid sequence represented by SEQ ID NO. 52; a heavy chain CDR2 comprising an amino acid sequence represented by SEQ ID NO. 53; and a heavy chain CDR3 comprising an amino acid sequence represented by SEQ ID NO. 54; and a light chain including a light chain CDR1 comprising an amino acid sequence represented by SEQ ID NO. 55; a light chain CDR2 comprising an amino acid sequence represented by SEQ ID NO. 56; and a light chain CDR3 comprising an amino acid sequence represented by SEQ ID NO. 57; (b) a heavy chain including a heavy chain CDR1 comprising an amino acid sequence represented by SEQ ID NO. 64; a heavy chain CDR2 comprising an amino acid sequence represented by SEQ ID NO. 65; and a heavy chain CDR3 comprising an amino acid sequence represented by SEQ ID NO. 66; and a light chain including a light chain CDR1 comprising an amino acid sequence presented by SEQ ID NO. 67; a light chain CDR2 comprising an amino acid sequence represented by SEQ ID NO. 68; and a light chain CDR3 comprising an amino acid sequence represented by SEQ ID NO. 69; or (c) a heavy chain including a heavy chain CDR1 comprising an amino acid sequence represented by SEQ ID NO. 40; a heavy chain CDR2 comprising an amino acid sequence represented by SEQ ID NO. 41; and a heavy chain CDR3 comprising an amino acid sequence represented by SEQ ID NO. 42; and a light chain including a light chain CDR1 comprising an amino acid sequence represented by SEQ ID NO. 43; a light chain CDR2 comprising an amino acid sequence represented by SEQ ID NO. 44; and a light chain CDR3 comprising an amino acid sequence represented by SEQ ID NO. 45.

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