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公开(公告)号：US12065511B2
公开(公告)日：2024-08-20
申请号：US16818560
申请日：2020-03-13
IPC分类号： C07K5/10 , A61K38/06 , A61K38/07 , C07C229/26 , C07D209/16 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/08 , C07K5/087 , C07K5/09 , C07K5/107 , C07K5/11 , G01N33/68
CPC分类号： C07K5/10 , A61K38/06 , A61K38/07 , C07C229/26 , C07D209/16 , C07K5/06 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/08 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/1016 , C07K5/1019 , G01N33/68
摘要： The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.
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公开(公告)号：US11879027B2
公开(公告)日：2024-01-23
申请号：US17317033
申请日：2021-05-11
申请人： Mipsalus ApS
IPC分类号： A61K31/787 , C08F220/18 , A61K9/00 , C08F2/22 , C08F2/32 , C08F226/06 , B01J20/26 , C07K1/22 , C07K5/06 , C07K5/08
CPC分类号： C08F220/18 , A61K9/0053 , A61K31/787 , B01J20/268 , C08F2/22 , C08F2/32 , C08F226/06 , C07K1/22 , C07K5/06 , C07K5/08
摘要： Disclosed is agents and methods that target metabolism malfunctions, inborne as well as acquired, as well as methods for preparation of the agents. In particular, the invention relates to methods for preparing molecular imprinted polymers with high binding capacity for phenylalanine or tyrosine, MIPs that bind phenylalanine or tyrosine, and methods for treating phenylketonuria, alkaptonuria, and hypertyrosinemia.
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公开(公告)号：US20230128167A1
公开(公告)日：2023-04-27
申请号：US17978800
申请日：2022-11-01
发明人： Lele LI , Changjiang Huang
摘要： The invention provides a new oligopeptide linker intermediate and a preparation method thereof. The preparation method of the oligopeptide intermediate is easily carried out under mild reaction conditions, and since almost no side reactions occur in the reaction, the method produces a high-purity product with fewer impurities and easy to be purified, achieving unexpected technical effects.
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公开(公告)号：US11566044B2
公开(公告)日：2023-01-31
申请号：US16633801
申请日：2018-07-26
摘要： There is provided a range of novel disulfide bond containing compounds. These disulfide bond containing compounds can be used in a variety of applications such as solid phase peptide synthesis, solid phase organic synthesis, formation of dendrimers, formation of macromolecules and formation cyclic peptides; and as a component of a delivery vehicle with a bioactive molecule.
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公开(公告)号：US11059858B2
公开(公告)日：2021-07-13
申请号：US16121244
申请日：2018-09-04
IPC分类号： C07K5/083 , C07K5/08 , C07K5/087 , C07K5/093 , C07K5/103 , C07K5/09 , C07K5/065 , C07K5/062 , C07K5/06
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R23 are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US11033600B2
公开(公告)日：2021-06-15
申请号：US16320681
申请日：2017-07-28
IPC分类号： A61K38/00 , A61K38/05 , A61K31/4015 , A61K31/662 , A61K31/223 , C07K5/06 , A61K31/225 , A61K31/5375 , A61K47/50 , A61P31/14 , A61K47/10 , A61K45/06
摘要： Disclosed herein are protease transition state inhibitor/analogue prodrug compounds selected from the group consisting of esters, carbamates, ester phosphates, and pharmaceutically acceptable salts thereof. Compositions containing such prodrugs are also disclosed, along with methods of using such compounds therapeutically or prophylactically against calicivirus, picornavirus, and/or coronavirus infection, as well as other conditions, such as malaria, cancer, stroke, heart attack, neural degeneration, cataracts, and glaucoma through inhibition of the variety of proteases associated with progression of such conditions.
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公开(公告)号：US11021513B2
公开(公告)日：2021-06-01
申请号：US16301168
申请日：2017-05-15
申请人： EMORY UNIVERSITY
发明人： Raymond F. Schinazi , Franck Amblard , Ladislau Kovari , Peng Liu , Shaoman Zhou , Benjamin D. Kuiper , Bradley J. Keusch
摘要： The present invention is directed to compounds, compositions and methods for preventing, treating or curing Norovirus infection in human subjects or other animal hosts.
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公开(公告)号：US11014963B2
公开(公告)日：2021-05-25
申请号：US16121300
申请日：2018-09-04
IPC分类号： C07K5/083 , C07K5/08 , C07K5/087 , C07K5/097 , C07K5/093 , A61P43/00 , A61P27/02 , A61P27/00 , A61P9/00 , A61P9/10 , C07K5/062 , C07K5/09 , C07K5/072 , C07K5/068 , C07K5/078 , C07K5/065 , C07K5/06
摘要： The invention provides novel compounds having the general formula (I) wherein R2, R3, R4, R5, R6, R7, R3, R8, R10, R11 and R23 are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US10960002B2
公开(公告)日：2021-03-30
申请号：US16301100
申请日：2017-05-15
发明人： Sophia Koo , Francisco Miguel Marty
IPC分类号： C07K5/06 , C12Q1/02 , G01N33/497 , A61P31/10 , A61K31/496 , A61K38/12 , A61K31/4164 , C12Q1/18 , A61K45/06 , A61K49/00 , C12Q1/04 , A01N37/46
摘要： Methods for diagnosing, treating, and monitoring the treatment of mucormycosis are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having mucormycosis.
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公开(公告)号：US20200325130A1
公开(公告)日：2020-10-15
申请号：US16848290
申请日：2020-04-14
申请人： YALE UNIVERSITY
发明人： Craig CREWS , Momar TOURE , Eunhwa KO , Saul JAIME-FIGUEROA
IPC分类号： C07D417/14 , C07K5/06 , C07K5/062 , A61K47/55 , A61K47/54
摘要： The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. The methods of the present invention comprise administering to the subject an pharmaceutically effective amount of at least one compound of the invention.
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