公开(公告)号：US20240352052A1

公开(公告)日：2024-10-24

申请号：US18682274

申请日：2022-08-10

申请人： Japan Science and Technology Agency

发明人： Tsuyoshi Mita ,  Satoshi Maeda ,  Hideaki Takano

IPC分类号： C07F9/53 ,  B01J31/24

CPC分类号： C07F9/5325 ,  B01J31/24

摘要： One aspect of the present invention is a method for producing a compound represented by following general formula (1), the method being characterized by including a step of mixing ethylene, a compound represented by following general formula (2), and a compound represented by following general formula (3) to react with each other to give a compound represented by following general formula (4):






A1 to A4 each independently represent an aromatic group, and Z1 and Z2 each independently represent an oxygen atom, a sulfur atom, or a borane (BH3), Z3 represents an oxygen atom or a sulfur atom, n1 to n3 each independently represent 0 or 1, and X represents a halogen atom.

公开(公告)号：US20240217938A1

公开(公告)日：2024-07-04

申请号：US18414198

申请日：2024-01-16

申请人： EMERGENT BIODEFENSE OPERATIONS LANSING LLC

发明人： Roy Wendall WARE ,  Aaron Leigh DOWNEY

IPC分类号： C07D239/47 ,  A61K31/513 ,  C07F9/6512 ,  C07F9/53

CPC分类号： C07D239/47 ,  A61K31/513 ,  C07F9/6512 ,  C07F9/53

摘要： The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.

公开(公告)号：US20240067668A1

公开(公告)日：2024-02-29

申请号：US18259696

申请日：2021-12-29

申请人： VORONOI INC. ,  B2SBIO INC.

发明人： Yi Kyung Ko ,  Ah Reum Han ,  Jin Hee Park ,  Yeong Deok Lee ,  Hye Rim Im ,  Kyun Eun Kim ,  Dong Keun Hwang ,  Su Been Nam ,  Myung Hoe Heo ,  Se Rin Cho ,  Eun Hwa Ko ,  Sung Hwan Kim ,  Hwan Geun Choi

IPC分类号： C07F9/53 ,  A61P35/00

CPC分类号： C07F9/5325 ,  A61P35/00

摘要： The present invention relates to a heteroaryl derivative compound and a use thereof. Since the heteroaryl derivative of the present invention exhibits excellent inhibitory activity against EGFR, the heteroaryl derivative can be usefully used as a therapeutic agent for EGFR-associated diseases.

公开(公告)号：US11912667B2

公开(公告)日：2024-02-27

申请号：US17348831

申请日：2021-06-16

申请人： EMERGENT BIODEFENSE OPERATIONS LANSING LLC

发明人： Roy Wendell Ware ,  Aaron Leigh Downey

IPC分类号： A61K31/513 ,  C07D239/47 ,  C07F9/6512 ,  C07F9/53

CPC分类号： C07D239/47 ,  A61K31/513 ,  C07F9/6512 ,  C07F9/53

摘要： The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.

公开(公告)号：US11780862B2

公开(公告)日：2023-10-10

申请号：US18175074

申请日：2023-02-27

申请人： Kinnate Biopharma Inc.

发明人： Toufike Kanouni ,  Robert S. Kania ,  Jason M. Cox

IPC分类号： C07F9/58 ,  C07F9/6584 ,  C07F9/53

CPC分类号： C07F9/58 ,  C07F9/5325 ,  C07F9/6584

摘要： Provided herein are inhibitors of MEK kinase, pharmaceutical compositions comprising said inhibitory compounds, and methods for using said MEK kinase inhibitory compounds for the treatment of disease.

公开(公告)号：US20230295198A1

公开(公告)日：2023-09-21

申请号：US18011359

申请日：2021-06-22

申请人： The Governing Council of the University of Toronto

发明人： Ning Yan ,  Pitchaimari Gnanasekar

IPC分类号： C07F9/53 ,  C07F9/6571 ,  C07F9/655 ,  C09D5/18

CPC分类号： C07F9/5337 ,  C07F9/65502 ,  C07F9/657172 ,  C09D5/18

摘要： The present application relates to flame retardant compounds of Formula (I) which are derived from vanillin and which comprise a phosphorus based flame retardant. The present application also relates to methods of using compounds of Formula (I) for forming flame retardant resins, prepolymers and interpenetrating polymer network (IPNs) and to processes of their preparation. The vanillin is, for example, from a bio-based source.

公开(公告)号：US20230287010A1

公开(公告)日：2023-09-14

申请号：US17794847

申请日：2021-01-25

申请人： SFC CO., LTD

发明人： Byung-sun YANG ,  Sung-hoon JOO ,  Bong-ki SHIN ,  Ji-hwan KIM ,  Hyeon-jun JO ,  Sung-eun CHOI

IPC分类号： C07F5/02 ,  H01L51/00 ,  C07F7/08 ,  C07F9/50 ,  C07F9/53 ,  H01L51/52

CPC分类号： C07F5/027 ,  C07F7/0812 ,  C07F9/53 ,  C07F9/5027 ,  H01L51/0002 ,  H01L51/008 ,  H01L51/0052 ,  H01L51/52 ,  H01L51/0054 ,  H01L51/0061 ,  H01L51/0064 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/0094 ,  C07B2200/05

摘要： A polycyclic aromatic derivative compound according to the present invention is employed in an organic layer in a device, thus being able to implement a high-efficiency organic light-emitting device, and thus can be industrially and effectively used in various display devices such as flexible displays, and illumination apparatuses such as monochromatic or white flat illumination and monochromatic or white flexible illumination.

公开(公告)号：US11673129B2

公开(公告)日：2023-06-13

申请号：US17066270

申请日：2020-10-08

申请人： ACENET INC.

发明人： Kiyoto Takamori ,  Takekatsu Shibata

IPC分类号： B01J31/02 ,  C07D219/06 ,  C07C63/06 ,  C07C51/235 ,  C07F15/06 ,  A61P31/04 ,  A61K31/14 ,  A61K33/20 ,  C07B61/00 ,  C07C29/48 ,  C07F9/53

CPC分类号： B01J31/0239 ,  A61K31/14 ,  A61K33/20 ,  A61P31/04 ,  B01J31/0204 ,  B01J31/0224 ,  B01J31/0271 ,  C07B61/02 ,  C07C29/48 ,  C07C51/235 ,  C07C63/06 ,  C07D219/06 ,  C07F15/06 ,  C07F15/065 ,  B01J2231/70 ,  C07B61/00 ,  C07F9/53

摘要： An object of a first aspect of the present invention is to provide a radical generating catalyst that can generate (produce) radicals under mild conditions. In order to achieve the above object, a first radical generating catalyst according to the first aspect of the present invention is characterized in that it includes ammonium and/or a salt thereof. A second radical generating catalyst according to the first aspect of the present invention is characterized in that it includes an organic compound having Lewis acidic properties and/or Brønsted acidic properties.

公开(公告)号：US20230142274A1

公开(公告)日：2023-05-11

申请号：US17800853

申请日：2021-02-19

申请人： SIMCERE PHARMACEUTICAL CO., LTD. ,  JIANGSU SIMCERE PHARMACEUTICAL CO., LTD.

发明人： Peng Gu ,  Lei Liu ,  Guobao Zhang ,  Chunyan Zhao ,  Renhong Tang ,  Jinsheng Ren

IPC分类号： C07F9/53 ,  C07D277/42 ,  C07D285/08 ,  C07D513/04 ,  C07D417/04 ,  C07D519/00 ,  C07D417/12 ,  C07D277/28 ,  C07D471/04 ,  C07D417/10 ,  C07D409/12 ,  C07D403/12 ,  C07D417/14

CPC分类号： C07F9/5333 ,  C07D277/42 ,  C07D285/08 ,  C07D513/04 ,  C07D417/04 ,  C07D519/00 ,  C07D417/12 ,  C07D277/28 ,  C07D471/04 ,  C07D417/10 ,  C07D409/12 ,  C07D403/12 ,  C07D417/14

摘要： The present application describes a substituted aryl compound used as an RAD51 inhibitor and a pharmaceutically acceptable salt thereof. The compound has the structure as represented by Formula (I) and has the substituents and structural features as described in the present application. Furthermore, the present application describes a pharmaceutical composition containing the compound as represented by Formula (I) or the pharmaceutically acceptable salt thereof, and the use of the compound as represented by Formula (I) or the pharmaceutically acceptable salt thereof and the pharmaceutical composition containing same in the preparation of a drug for preventing or treating RAD51 mediated diseases.

公开(公告)号：US11588111B2

公开(公告)日：2023-02-21

申请号：US15866885

申请日：2018-01-10

申请人： SAMSUNG DISPLAY CO., LTD.

发明人： Munki Sim ,  Junha Park ,  Hyoyoung Lee ,  Youngkook Kim ,  Seokhwan Hwang

IPC分类号： H01L51/50 ,  H01L51/00 ,  H01L51/52 ,  C07D471/04 ,  C07F9/53 ,  C07F9/6561 ,  C07F9/6568 ,  C07D519/00

摘要： A condensed cyclic compound and an organic light-emitting device, the compound being represented by Formula 1: