公开(公告)号：US12000809B2

公开(公告)日：2024-06-04

申请号：US17662512

申请日：2022-05-09

申请人： Iowa State University Research Foundation, Inc.

发明人： Jared L. Anderson ,  Kosuke Kuroda ,  He Nan

IPC分类号： G01N30/56 ,  B01D15/36 ,  B01J20/281 ,  C07D233/60 ,  G01N30/68 ,  G01N30/72 ,  G01N30/74 ,  G01N30/02

CPC分类号： G01N30/56 ,  B01D15/36 ,  C07D233/60 ,  G01N30/68 ,  G01N30/72 ,  G01N30/74 ,  G01N2030/025 ,  G01N2030/562

摘要： A gas chromatographic (GC) column using a zwitterionic compound and methods of use thereof are disclosed herein. The volatile free acids were observed to strongly retain on these zwitterionic compounds-based columns with excellent peak symmetry. By carefully tuning the structures of these zwitterionic compounds, different selectivity toward volatile free acids was demonstrated. These stationary phases possess a wide working range with thermal stabilities at higher temperatures.

公开(公告)号：US11834416B2

公开(公告)日：2023-12-05

申请号：US16698332

申请日：2019-11-27

申请人： Board of Trustees of Southern Illinois University ,  Vanderbilt University

发明人： Boyd M. Goodson ,  Eduard Y. Chekmenev ,  Bryce E. Kidd ,  Jamil A. Mashni ,  Miranda Limbach ,  Yuqing Hou ,  Fan Shi

IPC分类号： C07D233/60 ,  G01R33/28 ,  C07D401/06 ,  C07D241/12 ,  C07D213/63 ,  C07F9/6506 ,  B01J31/12 ,  C07D213/46 ,  G01R33/46

CPC分类号： C07D233/60 ,  B01J31/12 ,  C07D213/46 ,  C07D213/63 ,  C07D241/12 ,  C07D401/06 ,  C07F9/6506 ,  G01R33/282 ,  B01J2531/827 ,  G01R33/46

摘要： The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

公开(公告)号：US20230365491A1

公开(公告)日：2023-11-16

申请号：US18352955

申请日：2023-07-14

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Yoram Cohen ,  Micha Fridman ,  Roymon Joseph ,  Alissa Naugolny ,  Mark Feldman ,  Ido M. Herzog ,  Dana Kaizerman

IPC分类号： C07C217/54 ,  A61K31/138 ,  A61K31/4178 ,  A61K31/66 ,  A61K45/06 ,  C02F1/50 ,  C07D233/60 ,  C07F9/54 ,  C09D5/16

CPC分类号： C07C217/54 ,  A61K31/138 ,  A61K31/4178 ,  A61K31/66 ,  A61K45/06 ,  C02F1/50 ,  C07D233/60 ,  C07F9/5407 ,  C09D5/1687 ,  C02F2303/20

摘要： Cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives are capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition. A composition for inhibiting or disrupting biofilm, e.g., bacterial or fungal biofilm, formation, or reducing biofilm, can include a pharmaceutically acceptable carrier, and a cationic pillar[n]ene.

公开(公告)号：US11753366B2

公开(公告)日：2023-09-12

申请号：US17670423

申请日：2022-02-11

申请人： NIKANG THERAPEUTICS, INC.

发明人： Jiping Fu ,  Yan Lou ,  Yigang He

IPC分类号： C07D213/63 ,  C07D213/65 ,  C07C255/54 ,  C07C255/50 ,  C07C313/06 ,  A61P35/00 ,  A61P1/16 ,  A61P9/12 ,  A61P29/00 ,  A61K45/06 ,  A61K31/277 ,  A61K31/4412 ,  C07D233/60

CPC分类号： C07C255/54 ,  A61P35/00 ,  C07C313/06 ,  C07D213/63 ,  C07D233/60 ,  A61K45/06 ,  C07C2603/10 ,  C07C2603/97

摘要： The present disclosure provides certain tetrahydro-1H-cyclopenta[cd]indene compounds that are Hypoxia Inducible Factor 2α (HIF-2α) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2α. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

公开(公告)号：US11718587B2

公开(公告)日：2023-08-08

申请号：US16648585

申请日：2018-09-26

申请人： TOKYO OHKA KOGYO CO., LTD. ,  Daicel Corporation

发明人： Kunihiro Noda ,  Hiroki Chisaka ,  Issei Suzuki ,  Jiro Hikida ,  Dai Shiota ,  Kieko Hanano ,  Kyohei Ishida ,  Tsutomu Watanabe ,  Kazuhiro Uehara

IPC分类号： C07D233/60 ,  C07D233/58

CPC分类号： C07D233/60 ,  C07D233/58

摘要： A novel compound suitable as an epoxy curing catalyst; an epoxy curing catalyst using the compound; and a method for producing the compound. A compound represented by formula (1) in which Xm+ represents an m valent counter cation, R1 represents an aromatic group which may have a substituent; R2 represents an alkylene group which may have a substituent; R3 represents a halogen atom, a hydroxyl group, a mercapto group, a sulfide group, a silyl group, a silanol group, a nitro group, a nitroso group, a sulfonic acid ester group, a phosphino group, a phosphinyl group, a phosphonic acid ester group or an organic group; m represents an integer of 1 or more; n represents an integer of 0-3; and R2 may bond with R1 to form a cyclic structure.

公开(公告)号：US20230192631A1

公开(公告)日：2023-06-22

申请号：US17996325

申请日：2021-04-14

申请人： Hoffmann-La Roche Inc.

发明人： Stefan BERCHTOLD ,  Guido GALLEY ,  Katrin GROEBKE ZBINDEN ,  Wolfgang GUBA ,  Daniel HUNZIKER ,  Danny KRUMM

IPC分类号： C07D249/08 ,  C07D239/36 ,  C07D295/145 ,  C07C233/55 ,  C07D233/60 ,  C07C65/21

CPC分类号： C07D249/08 ,  C07D239/36 ,  C07D295/145 ,  C07C233/55 ,  C07D233/60 ,  C07C65/21

摘要： The invention relates to a compound of formula (I) wherein R1—R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US20220298122A1

公开(公告)日：2022-09-22

申请号：US17603659

申请日：2020-04-14

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Richard J. Fox ,  Carlos A. Guerrero ,  Michael Dummeldinger ,  Dimitri Skliar ,  Harshkumar Patel ,  Yichen Tan ,  David Thomas George

IPC分类号： C07D249/04 ,  C07C51/09 ,  C07C51/12 ,  C07C51/29 ,  C07D401/04 ,  C07D233/60

摘要： Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

公开(公告)号：US11312707B2

公开(公告)日：2022-04-26

申请号：US16464377

申请日：2017-11-24

申请人： CELLIX BIO PRIVATE LIMITED

发明人： Mahesh Kandula

IPC分类号： A61P1/02 ,  C07C211/03 ,  C07C211/21 ,  C07D233/64 ,  C07D405/14 ,  C07D233/60 ,  C07D233/62 ,  C07D239/22 ,  C07D403/06

摘要： The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX or Formula X and, the methods for the treatment of fungal infections may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of fungal infections.

公开(公告)号：US20220081401A1

公开(公告)日：2022-03-17

申请号：US17537298

申请日：2021-11-29

申请人： University of Tennessee Research Foundation

发明人： Ramesh Narayanan ,  Duane D. Miller ,  Thamarai Ponnusamy ,  Dong-Jin Hwang ,  Yali He

IPC分类号： C07D231/16 ,  A61P35/00 ,  A61P21/00 ,  C07D207/34 ,  C07C55/07 ,  C07C59/255 ,  C07D231/12 ,  C07D207/327 ,  C07D233/68 ,  C07D233/60 ,  C07D295/15 ,  C07D249/08 ,  C07D401/12 ,  C07D239/72 ,  C07D249/06

摘要： This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including cyclic and heterocyclic anilide rings and their synthetic precursors, and mono-, di-, or multi-substituted N-heterocyclic rings, R-isomers, non-hydroxylated and/or non-chiral propanamides in treating androgen receptor dependent diseases and conditions such as hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

公开(公告)号：US11161801B2

公开(公告)日：2021-11-02

申请号：US15751786

申请日：2016-08-03

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Yoram Cohen ,  Micha Fridman ,  Roymon Joseph ,  Alissa Naugolny ,  Mark Feldman ,  Ido M. Herzog ,  Dana Kaizerman

IPC分类号： C02F1/50 ,  C07C217/54 ,  C07D233/60 ,  C07F9/54 ,  C09D5/16 ,  A61K31/138 ,  A61K31/4178 ,  A61K31/66 ,  A61K45/06

摘要： The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.