公开(公告)号：US11919838B2

公开(公告)日：2024-03-05

申请号：US17305537

申请日：2021-07-09

申请人： REATA PHARMACEUTICALS HOLDINGS, LLC

发明人： Eric Anderson ,  Xin Jiang ,  Melean Visnick

IPC分类号： C07C255/47 ,  C07C271/24 ,  C07C275/26 ,  C07C275/34 ,  C07C311/07 ,  C07C311/09 ,  C07C311/10 ,  C07D209/56 ,  C07D211/44 ,  C07D231/12 ,  C07D261/08 ,  C07D261/20 ,  C07D295/195 ,  C07D295/215 ,  C07D307/20 ,  C07D333/34 ,  C07D487/08 ,  C07J63/00

CPC分类号： C07C255/47 ,  C07C271/24 ,  C07C275/26 ,  C07C275/34 ,  C07C311/07 ,  C07C311/09 ,  C07C311/10 ,  C07D209/56 ,  C07D211/44 ,  C07D231/12 ,  C07D261/08 ,  C07D261/20 ,  C07D295/195 ,  C07D295/215 ,  C07D307/20 ,  C07D333/34 ,  C07D487/08 ,  C07J63/008 ,  C07C2603/52

摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:




wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

公开(公告)号：US11495750B2

公开(公告)日：2022-11-08

申请号：US16461055

申请日：2017-10-26

申请人： ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.

发明人： Doo-Hyeon Moon ,  Bitnari Kim ,  Sang-Hee Cho

IPC分类号： H01L51/00 ,  C07D403/10 ,  C09K11/06 ,  C07D409/14 ,  C07D251/24 ,  C07D401/10 ,  C07D405/14 ,  H01L51/50 ,  C07D401/14 ,  C07D209/56

摘要： The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, an organic electroluminescent device having low driving voltage, high luminous efficiency, and/or excellent lifespan characteristics can be provided.

公开(公告)号：US11221557B2

公开(公告)日：2022-01-11

申请号：US16420961

申请日：2019-05-23

申请人： TOKYO OHKA KOGYO CO., LTD.

发明人： Takuya Ikeda ,  Masahiro Shiosaki ,  Masatoshi Arai ,  Yoshitaka Komuro

IPC分类号： G03F7/004 ,  G03F7/039 ,  C07C309/06 ,  C07D339/08 ,  C07C381/12 ,  C07C309/12 ,  C07D335/16 ,  C07D327/08 ,  C07D333/76 ,  C07D209/56 ,  G03F7/038 ,  G03F7/16 ,  G03F7/20 ,  G03F7/38 ,  G03F7/32

摘要： A resist composition containing a compound represented by the general formula (bd1-1), (bd1-2) or (bd1-3); in the formula, Rx1 to Rx4 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure; Ry1 to Ry2 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure, Rz1 to Rz4 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure. At least one of Rx1 to Rx4, Ry1 to Ry2 and Rz1 to Rz4 has an anion group, M1m+ represents a sulfonium cation having a sulfonyl group, R001 to R003 each independently represent a monovalent organic group; provided that at least one of R001 to R003 is an organic group having an acid dissociable group; and M3m+ represents an m-valent organic cation having an electron-withdrawing group.

公开(公告)号：US20210242410A1

公开(公告)日：2021-08-05

申请号：US17213157

申请日：2021-03-25

申请人： DUK SAN NEOLUX CO., LTD.

发明人： Mun Jae LEE ,  Soung Yun MUN ,  Jae Taek KWON ,  Dae Sung KIM ,  Moo Jin PARK ,  Sun Hee LEE ,  Sun Pil HWANG ,  Ho Young JUNG ,  Bum Sung LEE

IPC分类号： H01L51/00 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C09K11/06 ,  C07D209/82 ,  C07D209/56 ,  C07D405/12 ,  C07D409/14 ,  C07D401/04 ,  C07D405/14 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D209/80 ,  C07D209/86 ,  C07D209/88 ,  C07D403/04 ,  C07D403/10 ,  C07D409/12 ,  C07D519/00

摘要： Provided is an organic electric element and an electronic device thereof, by using the mixture of the compounds as a phosphorescent host material, it is possible to achieve a high luminous efficiency and a low driving voltage of an organic electric element, and the life span of the device can be greatly improved.

公开(公告)号：US11028084B2

公开(公告)日：2021-06-08

申请号：US16349580

申请日：2017-11-14

申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft ,  Forschungsverbund Berlin e.V.

发明人： Claus Scheidereit ,  Michael Willenbrock ,  Peter Lindemann ,  Silke Radetzki ,  Jens-Peter Von Kries ,  Marc Nazare

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D209/56 ,  C07D221/06 ,  C07D471/14 ,  C07D487/04 ,  C07D471/16

摘要： A method is for treatment of a disease associated with genotoxic stress-induced inhibitor of nuclear factor-κB kinase/nuclear factor kappa-light chain enhancer of activated B cells (IKK/NF-κB) signaling. The method can include administering a compound to a subject having a cancer exhibiting genotoxic stress induced IKK/NF-κB activation.

公开(公告)号：US10981869B2

公开(公告)日：2021-04-20

申请号：US16600269

申请日：2019-10-11

申请人： Rhode Island Board of Education, State of Rhode Island and Providence Plantations

发明人： Kyle Robert Scully ,  Roberta S. King ,  David R. Worthen

IPC分类号： C07D209/56 ,  C07D209/04 ,  C07D495/18 ,  C07D487/18 ,  A61K31/404 ,  A61K45/06

摘要： The invention provides bridged diindole compounds, related pharmaceutical compositions and methods of use thereof, for the prevention, palliation and/or treatment of nervous system disorders.

公开(公告)号：US20210015792A1

公开(公告)日：2021-01-21

申请号：US17034323

申请日：2020-09-28

申请人： Hoffmann-La Roche Inc.

发明人： Patrizio MATTEI ,  Daniel HUNZIKER ,  Patrick DI GIORGIO ,  Jerome HERT ,  Markus RUDOLPH ,  Lisha WANG

IPC分类号： A61K31/407 ,  C07D209/56 ,  C07D487/04

摘要： The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US10886474B2

公开(公告)日：2021-01-05

申请号：US15509590

申请日：2015-09-25

申请人： Rohm and Haas Electronic Materials Korea Ltd.

发明人： Doo-Hyeon Moon ,  Jeong-Eun Yang ,  Hee-Ryong Kang ,  Young-Mook Lim ,  Ji-Song Jun ,  Hee-Choon Ahn ,  Jin-Ri Hong ,  Su-Hyun Lee ,  Bitnari Kim ,  Tae-Jin Lee

IPC分类号： C07D209/56 ,  C07D209/88 ,  C07D209/86 ,  C07D209/82 ,  C07D405/02 ,  C07D405/10 ,  C07D405/04 ,  C07D409/02 ,  C07D409/10 ,  C09K11/06 ,  H01L51/00 ,  C07D409/04 ,  H01L51/50

摘要： The present disclosure relates to an organic electroluminescent compound, and an organic electroluminescent material and an organic electroluminescent device comprising the same. The organic electroluminescent compound of the present disclosure has excellent color purity, solubility, and thermal stability. By comprising the organic electroluminescent compound and the organic electroluminescent material of the present disclosure, an organic electroluminescent device showing low driving voltage, excellent current and power efficiencies, and significantly improved lifespan can be provided.

公开(公告)号：US10684274B2

公开(公告)日：2020-06-16

申请号：US16069483

申请日：2017-01-12

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION ,  Alexei Adzhubei

发明人： Alexei Adzhubei ,  Michael Bukrinsky ,  Ruth Hunegnaw

IPC分类号： G01N33/50 ,  C07C223/06 ,  C07D209/56 ,  C07C381/00 ,  A61K31/18 ,  A61K31/167 ,  A61K31/404

摘要： The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.

公开(公告)号：US10669244B2

公开(公告)日：2020-06-02

申请号：US15887956

申请日：2018-02-02

申请人： President and Fellows of Harvard College

发明人： Andrew G. Myers ,  Mark G. Charest ,  Christian D. Lerner ,  Jason D. Brubaker ,  Dionicio R. Siegel

IPC分类号： C07C237/26 ,  C07D209/56 ,  C07D235/02 ,  C07D237/26 ,  C07D239/70 ,  C07D241/38 ,  C07D263/52 ,  C07D307/77 ,  C07D261/20 ,  C07D209/58 ,  C07D213/56 ,  C07D221/18 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D277/66 ,  C07C231/10

摘要： The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.