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    Indoleamine 2,3-dioxygenase based immunotherapy
    2.
    发明授权
    Indoleamine 2,3-dioxygenase based immunotherapy 有权

    公开(公告)号：US12233103B2

    公开(公告)日：2025-02-25

    申请号：US18298263

    申请日：2023-04-10

    Applicant: IO BIOTECH APS

    Inventor： Mads Hald Andersen ,  Per Thor Straten

    IPC: A61K38/20 ,  A61K38/19 ,  A61K39/00 ,  A61K45/06 ,  C12N9/02

    Abstract: The invention relates to the field of prophylaxis and therapy of cancer. Provided is a Indoleamine 2,3-dioxygenase (IDO) or peptide fragments hereof that are capable of eliciting anti-cancer immune responses. Specifically, the invention relates to the use of IDO or peptides derived herefrom or IDO specific T-cells for treatment of cancer. The invention thus relates to an anti-cancer vaccine which optionally may be used in combination with other immunotherapies and to IDO specific T-cells adoptively transferred or induced in vivo by vaccination as a treatment of cancer. The invention also provides that the medicaments herein provided may be used in combination with cancer chemotherapy treatment. The invention further provides the prophylaxis and therapy of infections by the same means as described above. The use of IDO and immunogenic peptide fragments hereof in cancer and infection treatment, diagnosis and prognosis is also provided.

    SYSTEM AND METHOD FOR IMMUNOMODULATORY ENHANCEMENT OF IMPLANT BONE INTEGRATION
    5.
    发明申请
    SYSTEM AND METHOD FOR IMMUNOMODULATORY ENHANCEMENT OF IMPLANT BONE INTEGRATION 有权

    公开(公告)号：US20250057655A1

    公开(公告)日：2025-02-20

    申请号：US18449026

    申请日：2023-08-14

    Applicant: Loubert S. Suddaby

    Inventor： Loubert S. Suddaby

    IPC: A61F2/28 ,  A61K33/06 ,  A61K38/19

    Abstract: An immunomodulatory implant comprising an inner portion including a metal or polymer, an intermediate portion arranged on the inner portion and including a calcium compound, and an outer portion arranged on the intermediate portion, the outer portion including a calcium containing carrier substrate and an immunomodulatory enhancement which favors osteogenic bone growth into the implant such that a stable bone implant integration occurs.

    Nano-satellite complexes
    6.
    发明授权
    Nano-satellite complexes 有权

    公开(公告)号：US12226491B2

    公开(公告)日：2025-02-18

    申请号：US17232751

    申请日：2021-04-16

    Applicant: The Regents of the University of Michigan

    Inventor： Duxin Sun ,  Ryan Clauson ,  Hongwei Chen ,  Chengyi Li ,  Wei Gao ,  Luke Bugada ,  Fei Wen ,  Brett Hill ,  Syed Monem Rizvi

    IPC: A61K47/69 ,  A61K9/16 ,  A61K38/19 ,  A61K39/00 ,  A61K39/295 ,  A61K39/39 ,  A61K45/06 ,  A61K47/02 ,  A61K47/64 ,  A61P35/00

    Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).

    Cardiac stem cells for cardiac repair
    7.
    发明授权
    Cardiac stem cells for cardiac repair 有权

    公开(公告)号：US12220432B2

    公开(公告)日：2025-02-11

    申请号：US18175154

    申请日：2023-02-27

    Applicant: University of Maryland, Baltimore

    Inventor： Sunjay Kaushal

    IPC: A61K35/34 ,  A61K38/18 ,  A61K38/19 ,  A61P9/10

    Abstract: Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.

    CARDIAC STEM CELLS FOR CARDIAC REPAIR
    8.
    发明申请
    CARDIAC STEM CELLS FOR CARDIAC REPAIR 有权

    公开(公告)号：US20250032553A1

    公开(公告)日：2025-01-30

    申请号：US18914834

    申请日：2024-10-14

    Applicant: University of Maryland, Baltimore

    Inventor： Sunjay KAUSHAL

    IPC: A61K35/34 ,  A61K38/18 ,  A61K38/19 ,  A61P9/10

    Abstract: Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.

    Advanced avatar dendritic cells
    10.
    发明授权
    Advanced avatar dendritic cells 有权

    公开(公告)号：US12195520B2

    公开(公告)日：2025-01-14

    申请号：US18679187

    申请日：2024-05-30

    Applicant: ImmunityBio, Inc.

    Inventor： Patrick Soon-Shiong

    IPC: C07K14/715 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K45/06 ,  C07K14/52 ,  C07K14/54 ,  C07K14/71

    Abstract: Compositions, methods, and uses of recombinant immunoglobulin proteins, recombinant immunoglobulin protein complexes, carrier protein complexes, and a pharmaceutical composition including one or more of those to increase immune therapy effectiveness are presented. Preferred protein and protein complex comprise one or more functional moieties that includes a binding motif to a tumor-associated antigen, a T-cell activating molecule, and a chemokine. In some embodiments, the pharmaceutical composition includes two or more protein complexes, which are functionally distinct from each other. In other embodiments, the pharmaceutical composition includes a genetically-engineered microorganism including a first tumor-associated antigen and a T-cell activating molecule, a recombinant immunoglobulin protein complex, and a chemokine.

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