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公开(公告)号：US12070466B2
公开(公告)日：2024-08-27
申请号：US17335496
申请日：2021-06-01
申请人： Sydnexis, Inc.
IPC分类号： A61K31/5575 , A61K9/00 , A61K9/06 , A61K9/08 , A61K31/18 , A61K31/216 , A61K31/565 , A61K31/57 , A61K47/02 , A61K47/34 , A61K47/38 , A61P27/02
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K31/18 , A61K31/216 , A61K31/565 , A61K31/57 , A61K47/02 , A61K47/34 , A61K47/38 , A61P27/02
摘要： Provided herein is an ophthalmic composition formulated in deuterated water. Also disclosed herein are methods of treating, ameliorating, or reducing ophthalmic conditions or diseases by administering to an eye of an individual in need thereof an effective amount of an ophthalmic composition as described herein.
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公开(公告)号：US12064440B2
公开(公告)日：2024-08-20
申请号：US18187507
申请日：2023-03-21
IPC分类号： A61K31/5575 , A61K9/00 , A61K9/06 , A61K9/08 , A61K31/5377 , A61K47/02 , A61K47/18
CPC分类号： A61K31/5575 , A61K9/0019 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K31/5377 , A61K47/02 , A61K47/186
摘要： The present invention provides pharmaceutically acceptable and ophthalmologically suitable gel compositions comprising a therapeutically effective amount of a bimatoprost compound, a therapeutically effective amount of a timolol compound, and benzalkonium chloride. In certain embodiments, compositions provided by the invention further comprise a penetration enhancer component other than benzalkonium chloride. Further, the invention provides a process of preparing such compositions and methods of their use in treating ocular conditions, such as methods of reducing elevated intraocular pressure and/or treating glaucoma, such as open-angle glaucoma.
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公开(公告)号：US12053541B2
公开(公告)日：2024-08-06
申请号：US17336283
申请日：2021-06-01
申请人： Triple Hair Inc.
发明人： Houfar Sekhavat
IPC分类号： A61K8/63 , A61K8/02 , A61K8/04 , A61K8/36 , A61K8/37 , A61K8/49 , A61K9/00 , A61K31/506 , A61K31/5575 , A61K31/58 , A61Q7/00
CPC分类号： A61K8/63 , A61K8/0204 , A61K8/046 , A61K8/361 , A61K8/37 , A61K8/4953 , A61K31/506 , A61K31/5575 , A61K31/58 , A61Q7/00 , A61K9/0014 , A61K2800/592 , A61K31/506 , A61K2300/00 , A61K31/58 , A61K2300/00 , A61K31/5575 , A61K2300/00
摘要： The invention relates to a composition comprising 2% to 5% minoxidil, 0.01% to 15% finasteride and 0.01% to 15% of a prostaglandin analogue. In one embodiment, the prostaglandin analogue is latanoprost. In a preferred embodiment, the composition comprises 5% minoxidil, 0.1% finasteride and 0.03% latanoprost. The invention also relates to the use of the said composition to reduce hair loss and/or increase regrowth of hair in a human subject.
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公开(公告)号：US20240207287A1
公开(公告)日：2024-06-27
申请号：US18381752
申请日：2023-10-19
申请人： Allergan, Inc.
发明人： James Chang , Patrick Hughes , Chin-Ming Chang
IPC分类号： A61K31/5575 , A61K9/00 , A61K9/107 , A61K9/14 , A61K9/16 , A61K31/165 , A61K47/34 , B01J13/04 , B01J13/06
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/0051 , A61K9/107 , A61K9/1075 , A61K9/146 , A61K9/1647 , A61K9/1694 , A61K31/165 , A61K47/34 , B01J13/04 , B01J13/06
摘要： Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.
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公开(公告)号：US20240197734A1
公开(公告)日：2024-06-20
申请号：US18594494
申请日：2024-03-04
申请人： Aneira Pharma, Inc.
发明人： John Edward Wurst
IPC分类号： A61K31/506 , A61K9/00 , A61K31/222 , A61K31/25 , A61K31/5575 , A61K31/58 , A61K38/13 , A61K47/10 , A61K47/12 , A61K47/26 , A61P17/14
CPC分类号： A61K31/506 , A61K9/0014 , A61K31/222 , A61K31/25 , A61K31/5575 , A61K31/58 , A61K38/13 , A61K47/10 , A61K47/12 , A61K47/26 , A61P17/14
摘要： Compositions and methods for the treatment of hair growth and the prevention of hair loss.
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公开(公告)号：US11992551B2
公开(公告)日：2024-05-28
申请号：US17214471
申请日：2021-03-26
申请人： GLAUKOS CORPORATION
发明人： David S. Haffner
CPC分类号： A61K9/0051 , A61F9/0017 , A61F9/00781 , A61K31/5575 , A61K47/02 , A61K47/32 , A61F2250/0067 , A61F2250/0068
摘要： Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
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7.发明公开公开(公告)号：US20240166613A1
公开(公告)日：2024-05-23
申请号：US18422255
申请日：2024-01-25
发明人： Bruce E. Heck , Dong Hyun Kim , Paul W. Erhardt , Brian J. Kress
IPC分类号： C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/22 , C07D277/28
CPC分类号： C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/22 , C07D277/28
摘要： Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures. treating osteoporosis and/or metabolic bone diseases. and inducing osteogenesis and/or chondrogenesis, are disclosed.
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公开(公告)号：US20240165108A1
公开(公告)日：2024-05-23
申请号：US18366944
申请日：2023-08-08
IPC分类号： A61K31/495 , A61K31/4375 , A61K31/5575 , A61P17/14
CPC分类号： A61K31/495 , A61K31/4375 , A61K31/5575 , A61P17/14
摘要： The present disclosure relates to an inhibitor of GPR91 for use in the treatment or prevention of hair-loss related disorders such as androgenetic alopecia. Combination therapies are also described. The present disclosure also provides an inhibitor of GPR91 for use in inducing or promoting hair growth in a human and methods thereof.
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公开(公告)号：US20240156833A1
公开(公告)日：2024-05-16
申请号：US18049952
申请日：2022-10-26
发明人： William Hite , Nilesh Parikh
IPC分类号： A61K31/5575 , A61K9/00 , A61K47/02 , A61K47/12 , A61K47/18
CPC分类号： A61K31/5575 , A61K9/0048 , A61K47/02 , A61K47/12 , A61K47/183
摘要： Aqueous pharmaceutical compositions, suitable for topical ophthalmic administration to a mammal, that comprise a therapeutically effective amount of a prostaglandin, less than 0.3% w/v, and no added benzalkonium chloride, are provided. Such compositions are useful in methods comprising their topical administration to mammalian subjects, e.g., humans and reducing intraocular pressure and/or ocular hyperemia in the patient. Such compositions are also useful in methods comprising their topical administration to mammalian subjects, e.g., humans and promoting eyelash growth in the patient.
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公开(公告)号：US20240115551A1
公开(公告)日：2024-04-11
申请号：US18529306
申请日：2023-12-05
申请人： Glaukos Corporation
IPC分类号： A61K31/4178 , A61K9/00 , A61K9/06 , A61K31/27 , A61K31/46 , A61K31/498 , A61K31/5575 , A61K31/56 , A61K38/13 , A61K47/02 , A61K47/12
CPC分类号： A61K31/4178 , A61K9/0048 , A61K9/06 , A61K31/27 , A61K31/46 , A61K31/498 , A61K31/5575 , A61K31/56 , A61K38/13 , A61K47/02 , A61K47/12
摘要： Described herein are formulations including pharmaceutical agents comprising ester and/or lactone ring structures, and methods of using the same. The invention is also directed to a method and ophthalmic pharmaceutical compositions including solution and semisolid dosage forms (i.e. ophthalmic creams, gels, lotions, serums, and/or ointments) of treating a patient with various ocular diseases including presbyopia and dry eyes. The method comprising instructing a patient to apply one strip of the ophthalmic composition to the eyelids that includes pilocarpine or other active pharmaceutical ingredients containing ester and/or lactone ring structures with and without the buffering system.
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