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公开(公告)号：US10570134B2
公开(公告)日：2020-02-25
申请号：US16415321
申请日：2019-05-17
Applicant: MERCK & CIE
Inventor： Rudolf Moser , Viola Groehn , Thomas Egger , Thomas Ammann
IPC: C07D475/12 , C07D475/04 , A61K31/519 , A61K9/08 , A61K9/19 , A61K9/00
Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
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公开(公告)号：US20130225593A1
公开(公告)日：2013-08-29
申请号：US13767602
申请日：2013-02-14
Applicant: Christian EICKMEIER , Kai GERLACH , Niklas HEINE , Alexander WEBER , Ulrike GROSS
Inventor： Christian EICKMEIER , Kai GERLACH , Niklas HEINE , Alexander WEBER , Ulrike GROSS
IPC: C07D491/20 , C07D475/12
CPC classification number: C07D491/20 , A61K31/519 , C07D475/00 , C07D475/12
Abstract: The present invention relates to spiroheterocycl-dihydropyrimidines, their use as modulators of γ-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with γ-secretase and/or its substrate and therefore modulate the formation of Aβ peptides.
Abstract translation: 本发明涉及螺杂环 - 二氢嘧啶，它们作为γ-分泌酶的调节剂和含有所述化合物的药物组合物的用途。 特别地，本发明涉及干扰γ-分泌酶和/或其底物并因此调节Aβ肽形成的化合物。
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公开(公告)号：US07547780B2
公开(公告)日：2009-06-16
申请号：US11958750
申请日：2007-12-18
Applicant: Matthias Grauert , Matthias Hoffman , Christian Eickmeier
Inventor： Matthias Grauert , Matthias Hoffman , Christian Eickmeier
IPC: C07D475/12 , A61P35/00 , C07D239/30 , C07D475/00
CPC classification number: C07D487/04 , C07D475/00 , Y02P20/55
Abstract: Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
Abstract translation: 公开了通式（I）的新的二氢蝶啶酮，其中基团L，R 1，R 2，R 3，R 4和R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的方法及其作为药物组合物的用途。
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公开(公告)号：US3311627A
公开(公告)日：1967-03-28
申请号：US56105166
申请日：1966-06-28
Applicant: AMERICAN HOME PROD
Inventor： WENDT GERHARD R , LEDIG KURT W
IPC: C07D475/00 , C07D475/12
CPC classification number: C07D475/12 , C07D475/00
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公开(公告)号：US20240407260A1
公开(公告)日：2024-12-05
申请号：US18577046
申请日：2022-06-28
Applicant: TOSOH CORPORATION
Inventor： Nobumichi ARAI , Takeshi OKADA , Yasuhiro TAKAHASHI , Keisuke NOMURA
IPC: H10K85/60 , C07D241/36 , C07D475/12 , H10K30/86
Abstract: Provided are a material for a light receiving element having excellent hole transport characteristics, and an organic light receiving element using the same.
A material for a light receiving element is used that includes a compound represented by general formula (1) or general formula (2). Ar2 and Ar3 are preferably cyano groups. Ar and Ar5 are preferably cyano groups.-
Patent Agency Ranking
公开(公告)号：US12103930B2
公开(公告)日：2024-10-01
申请号：US17583994
申请日：2022-01-25
Applicant: MERCK & CIE
Inventor： Rudolf Moser , Viola Groehn , Thomas Egger , Thomas Ammann
IPC: C07D475/12 , A61K9/00 , A61K9/08 , A61K9/19 , A61K31/282 , A61K31/395 , A61K31/4745 , A61K31/519 , A61K39/395 , C07D475/04
CPC classification number: C07D475/12 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/19 , A61K31/282 , A61K31/4745 , A61K31/519 , A61K39/3955 , C07D475/04 , C07B2200/13 , A61K31/519 , A61K2300/00
Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
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公开(公告)号：US20230102721A1
公开(公告)日：2023-03-30
申请号：US17787389
申请日：2020-12-28
Inventor： Hyunseo SHIN , Young Jea KANG , Seok-Won LEE , Bongjin MOON , Myeonghwa JEONG , Sangeun YOON
IPC: C07D475/12 , C12Q1/26 , C12Q1/00
Abstract: The present invention relates to a novel organic electron-transfer mediator showing an excellent oxidation-reduction potential and a device such as an electrochemical biosensor having improved performance comprising the same.
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公开(公告)号：US20200283443A1
公开(公告)日：2020-09-10
申请号：US16796164
申请日：2020-02-20
Applicant: MERCK & CIE
Inventor： Rudolf MOSER , Viola GROEHN , Thomas EGGER , Thomas AMMANN
IPC: C07D475/12 , A61K31/519 , A61K9/08 , A61K9/19 , A61K9/00 , C07D475/04
Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
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公开(公告)号：US10059710B2
公开(公告)日：2018-08-28
申请号：US15435787
申请日：2017-02-17
Applicant: MERCK & CIE
Inventor： Rudolf Moser , Viola Groehn , Thomas Egger , Thomas Ammann
IPC: A61K9/08 , A61K31/519 , A61K9/19 , C07D475/12
CPC classification number: C07D475/12 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/519 , C07B2200/13 , C07D475/04 , A61K2300/00
Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
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公开(公告)号：US08809527B2
公开(公告)日：2014-08-19
申请号：US14089633
申请日：2013-11-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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