公开(公告)号：US3694431A

公开(公告)日：1972-09-26

申请号：US3694431D

申请日：1970-09-16

Applicant: JULIUS J FUCHS ,  HARVEY M LOUX

Inventor： FUCHS JULIUS J ,  LOUX HARVEY M

IPC: C07D295/12 ,  C07D295/20 ,  C07D29/22

CPC classification number: C07D295/12 ,  C07D295/20

Abstract: 1-(Carbamoyl)-N-(carbamoyloxy)thioformimidates such as methyl 1(carbamoyl)-N-methylcarbamoyloxy)thioformimidate and methyl 1(dimethylcarbamoyl)-N-(methylcarbamoyloxy)thioformimidate are prepared by the steps of A. REACTING DIKETENE WITH AMMONIA OR AN AMINE TO OBTAIN AN ACETOACETAMIDE; B. REACTING THE PRODUCT OF (A) WITH A NITROSATING AGENT IN THE PRESENCE OF WATER OR AN ALCOHOL; C. CHLORINATING THE PRODUCT OF (B) AT A TEMPERATURE OF -10 TO 75* C.; d. reacting the product of (c) with an alkyl mercaptan and a base or with a metal salt of an alkyl mercaptan; and E. REACTING THE PRODUCT OF (D) WITH 1. A CARBAMOYL CHLORIDE IN THE PRESENCE OF A BASE; 2. PHOSGENE FOLLOWED BY REACTION WITH AN AMINE; OR 3. AN ISOCYANATE, OPTIONALLY IN THE PRESENCE OF A BASIC CATALYST; IN WATER OR ORGANIC SOLVENTS SUCH AS ACETONE, METHYLENE CHLORIDE, METHYL ETHYL KETONE, METHYL ISOBUTYL KETONE, DIMETHYLFORMAMIDE, DIMETHYLACETAMIDE, DIMETHYLSULFOXIDE, TETRAMETHYLUREA OR THEIR MIXTURES.

Abstract translation: 通过以下步骤制备1-（氨甲酰基）-N-（氨基甲酰氧基）硫代甲亚胺酸酯如1-（氨基甲酰基）-N-甲基氨基甲酰氧基）硫代甲酰亚胺酯和1-（二甲基氨基甲酰基）-N-（甲基氨基甲酰氧基）硫代甲亚胺酸甲酯。反应DIKETENE 用氨基酸或胺获得乙酰胺; B.在水或酒精存在下，使用硝基化剂反应（A）的产物; C.在-10℃至75℃的温度下将（B）的产物进行氯化。

公开(公告)号：US3511844A

公开(公告)日：1970-05-12

申请号：US3511844D

申请日：1968-03-29

Applicant: MCNEILAB INC

Inventor： PLOSTNIEKS JANIS

IPC: C07D211/22 ,  C07D211/26 ,  C07D211/78 ,  C07D29/22 ,  C07D29/28

CPC classification number: C07D211/78 ,  C07D211/22 ,  C07D211/26

公开(公告)号：US3471469A

公开(公告)日：1969-10-07

申请号：US3471469D

申请日：1967-05-23

Applicant: HOECHST AG

Inventor： MEININGER FRITZ ,  BAUER AUGUST

IPC: C09B62/51 ,  C07D29/22

CPC classification number: C09B62/51

公开(公告)号：US3644409A

公开(公告)日：1972-02-22

申请号：US3644409D

申请日：1970-05-28

Applicant: BRACCO IND CHIMICA SPA

Inventor： FELDER ERNST ,  PITRE DAVIDE

IPC: A61K49/04 ,  C07D207/26 ,  C07D207/27 ,  C07D211/02 ,  C07D211/76 ,  C07D265/32 ,  C07D27/08 ,  C07D29/22 ,  C07D87/30

CPC classification number: C07D207/27 ,  A61K49/0495 ,  C07D211/02 ,  C07D211/76 ,  C07D265/32

Abstract: COMPOUNDS OF THE FORMULA

1,3,5-TRI(I-),4-(HOOC-ALK-Y-),6-((-CO-X-CH2-)>N-)BENZENE

ARE RADIOPAQUE, TEND TO COLLECT IN THE GALL BLADDER WHEN INGESTED ORALLY, AND ARE WELL TOLERATED, IF X HAS 2-4 CARBON ATOMS AND IS ALKYLENE OR ALKYLENOXYALKYLENE, Y IS A SINGLE CARBON-TO-CARBON BOND OR OXYGEN, AND AKL IS LOWER ALKYLENE OR PHENYL-LOWER-ALKYLENE HAVING NOT MORE THAN FOUR CARBON ATOMS IN THE ALKYLENE GROUP. THE PHYSIOLOGICALLY TOLERATED SALTS OF THE ABOVE CARBOXYLIC ACIDS HAVE THE SAME EFFECTS. THE COMPOUNDS ARE PREPARED BY CLOSURE OF THE RING

-N
WHEN OTHERWISE SIMILAR COMPOUNDS HAVING THE GROUP

-NH-CO-X-CH2-Z

ARE EXPOSED TO ALKALI METAL HYDROXIDE IN A STRONGLY ALKALINE AQUEOUS MEDIUM AND ARE PRECIPITATED WHEN THE MEDIUM IS ACIDIFIED AFTER RING FORMATION.

公开(公告)号：US3644375A

公开(公告)日：1972-02-22

申请号：US3644375D

申请日：1969-05-02

Applicant: TORAY INDUSTRIES

Inventor： KOBAYASHI TSUNEO ,  MORITA KENICHI ,  KITAGAWA HIROSHI ,  YOKOYAMA TOSHIMITSU ,  MAKIDA SBIGEO

IPC: C07D207/26 ,  C07D207/277 ,  C07D211/78 ,  C07D27/08 ,  C07D29/22

CPC classification number: C07D207/277 ,  C07D211/78

Abstract: LACTAM DICARBOXYLIC ACIDS REPRESENTED BY THE GENERAL FORMULA:

OC
R REPRESENTS A HYDROGEN ATOM OR A HYDROCARBON GROUP HAVING LESS THAN 20 CARBON ATOMS. M REPRESENTS EITHER

-CH2-CH(-COOH)- OR -CH(-CH2-COOH)-

DERIVATIVES OF THE LACTAM DICARBOXYLIC ACID ARE ALSO DISCLOSED. PROCESS FOR PREPARING THE DIESTER OR DIAMIDE OF THE ABOVE LACTAM DICARBOXYLIC ACID WHICH COMPRISES REACTING 3-BUTENE-1,2,3-TRICARBOXYLIC ACID TRIESTER WITH AMMONIA OR A PRIMARY AMINE HAVING LESS THAN 20 CARBON ATOMS IS ALSO DISCLOSED.

公开(公告)号：US3491088A

公开(公告)日：1970-01-20

申请号：US3491088D

申请日：1966-07-29

Applicant: AMERICAN HOME PROD

Inventor： DOBSON THOMAS A ,  DAVIS MARTIN A

IPC: C07D471/08 ,  C07D493/08 ,  C07D41/06 ,  A61K27/00 ,  C07D29/22

CPC classification number: C07D471/08 ,  C07D493/08 ,  Y10S514/886

公开(公告)号：US3454558A

公开(公告)日：1969-07-08

申请号：US3454558D

申请日：1963-07-25

Applicant: GAF CORP

Inventor： STAHL CLARENCE RICHARD ,  SIGGIA SIDNEY

IPC: C08F2/38 ,  C07D27/08 ,  C07D29/22 ,  C07D41/06

CPC classification number: C08F2/38

公开(公告)号：US3440245A

公开(公告)日：1969-04-22

申请号：US3440245D

申请日：1964-12-11

Applicant: SUMITOMO CHEMICAL CO

Inventor： KATO TAKEAKI ,  UEDA KENZO ,  HORIE SADAO ,  MIZUTANI TOSHIO ,  FUJIMOTO KEIMEI ,  OKUNO YOSITOSI

IPC: A01N53/04 ,  C07D211/88 ,  C07D29/22 ,  A01N9/22 ,  C07D29/20

CPC classification number: C07D211/88

公开(公告)号：US3755335A

公开(公告)日：1973-08-28

申请号：US3755335D

申请日：1971-03-17

Applicant: ANVAR

Inventor： HUSSON H ,  THAL C ,  POTIER P

IPC: C07D461/00 ,  C07D471/14 ,  C07D29/22

CPC classification number: C07D471/14 ,  C07D461/00

Abstract: The invention relates to new indole derivatives which are useful therapeutical agents. Said new derivatives are 1,2,3,5,6,12,13,13a-octahydro-12-oxo(3,2,1-d,e)-indolo-(3,2,1-i,j)-pyrido -(1,5)-naphthyridines having the general formula

IN WHICH R1 and R2, which may be the same or different, are selected from H, OH and OCH3, and R3 is selected from H, Cl, Br and -COCO2C2H5.

Abstract translation: 本发明涉及作为有用的治疗剂的新的吲哚衍生物。

公开(公告)号：US3754088A

公开(公告)日：1973-08-21

申请号：US3754088D

申请日：1971-05-17

Applicant: MERCK & CO INC

Inventor： WITZEL B

IPC: C07D211/02 ,  C07D211/76 ,  C07D211/78 ,  C07D29/22

CPC classification number: C07D211/78 ,  C07D211/02 ,  C07D211/76

Abstract: METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION, PAIN AND FEVER EMPLOYING PIPERIDONES AND THIROPIPERIDONES.