公开(公告)号：US06656328B2

公开(公告)日：2003-12-02

申请号：US10070877

申请日：2002-03-05

Applicant: Syunsaku Kato ,  Daisuke Suzuki ,  Yoshiko Seo

Inventor： Syunsaku Kato ,  Daisuke Suzuki ,  Yoshiko Seo

IPC: C07C3700

CPC classification number: C07J1/0077 ,  C07B41/02 ,  C07C37/055 ,  C07C2603/42 ,  C07D213/69 ,  C07D309/30 ,  C07J1/00 ,  C07J1/0055 ,  C07J1/007 ,  Y02P20/55 ,  C07C39/14 ,  C07C39/12 ,  C07C39/10

Abstract: A process for preparing a polyhydric alcohol according to the invention comprises subjecting a polyhydric alcohol compound having protected hydroxy group(s) to microwave irradiation in the presence of basic compound(s) or acid(s) having an acid dissociation exponent (pKa) of −8 to 3 at 25° C. to remove the protecting groups of the hydroxy group of the polyhydric alcohol compound. The invention can provide an industrially advantageous process for preparing polyhydric alcohols by readily removing protecting group(s) from protected hydroxy group(s) of polyhydric alcohol compounds.

公开(公告)号：US06593501B2

公开(公告)日：2003-07-15

申请号：US09948787

申请日：2001-09-10

Applicant: Hitoshi Ota ,  Masaru Aga

Inventor： Hitoshi Ota ,  Masaru Aga

IPC: C07C3700

CPC classification number: C07C37/16 ,  Y02P20/582 ,  C07C39/07

Abstract: A process for producing an aromatic hydroxyl compound alkylated at the ortho position in high yield by subjecting an aromatic hydroxyl compound and an alkyl alcohol to a gas phase catalytic reaction in the presence of a metal oxide catalyst. The aromatic hydroxyl compound is a mixture of a phenol and ortho cresol, and the amount of ortho cresol in the mixture is 0.6 mole or less per 1 mole of phenol.

Abstract translation: 通过在金属氧化物催化剂的存在下使芳香族羟基化合物和烷基醇进行气相催化反应，生成以高收率在邻位烷基化的芳香族羟基化合物的方法。 芳族羟基化合物是苯酚和邻甲酚的混合物，混合物中邻甲酚的量相对于每1摩尔酚为0.6摩尔或更少。

公开(公告)号：US06441248B1

公开(公告)日：2002-08-27

申请号：US09511029

申请日：2000-02-23

Applicant: Gregory Kaplan

Inventor： Gregory Kaplan

IPC: C07C3700

CPC classification number: C07C37/11 ,  C07C37/07 ,  C07C37/50 ,  Y02P20/582 ,  C07C39/15

Abstract: This invention relates to a method for producing biphenols by oxidative coupling of dialkylphenols which proceeds in two stages using a copper amine complex which is catalytically effective in each stage.

Abstract translation: 本发明涉及通过二元酚的氧化偶联制备双酚的方法，该方法在两个阶段中使用每个阶段催化有效的铜胺络合物进行。

公开(公告)号：US06417409B1

公开(公告)日：2002-07-09

申请号：US09502229

申请日：2000-02-11

Applicant: Steffen Krill ,  Klaus Huthmacher

Inventor： Steffen Krill ,  Klaus Huthmacher

IPC: C07C3700

CPC classification number: C07C67/00 ,  Y02P20/582 ,  C07C69/017 ,  C07C69/16

Abstract: The invention relates to an improved process for the production of 2,3,5-trimethylhydroquinone diesters by rearrangement of 2,6,6-trimethyl-2-cyclohexene-1,4-dione (4-oxoisophorone, ketoisophorone) in the presence of a dissolved, acidic catalyst and an acylating agent, such as for example carboxylic anhydrides or carboxylic acid halides. The 2,3,5-trimethylhydroquinone diester can optionally then be saponified to give free 2,3,5-trimethylhydroquinone (TMHQ), which is a valuable building block in the synthesis of vitamin E.

Abstract translation: 本发明涉及通过在2,6,6-三甲基-2-环己烯-1,4-二酮（4-氧代异佛尔酮，酮异佛尔酮）的存在下重排来制备2,3,5-三甲基氢醌二酯的改进方法 溶解的酸性催化剂和酰化剂，例如羧酸酐或羧酸卤化物。 可以任选地将2,3,5-三甲基氢醌二酯皂化，得到游离的2,3,5-三甲基氢醌（TMHQ），其是维生素E合成中的有价值的结构单元。

公开(公告)号：US06232510B1

公开(公告)日：2001-05-15

申请号：US09259653

申请日：1999-02-26

Applicant: Terence Michael Barnhart

Inventor： Terence Michael Barnhart

IPC: C07C3700

CPC classification number: C07C37/58 ,  Y02P20/52 ,  C07C39/04

Abstract: A method and composition are disclosed for the oxidation of aromatic substrates in the presence of oxygen, a catalyst, a proton source, and a non-gaseous reductant. In a preferred embodiment, benzene is oxidized to phenol in the presence of oxygen, a vanadyl catalyst, trifluoroacetic acid as a proton source, and ferrocene as a reductant. The method is economical, safe, and amenable to commercial scale-up.

Abstract translation: 公开了在氧气，催化剂，质子源和非气态还原剂存在下氧化芳族底物的方法和组合物。 在优选的实施方案中，在氧的存在下，苯的氧被氧化成苯酚，作为质子源的氧钒基催化剂，三氟乙酸和作为还原剂的二茂铁。 该方法是经济，安全和易于商业化的。

公开(公告)号：US06800605B1

公开(公告)日：2004-10-05

申请号：US09761050

申请日：2001-01-16

Applicant: Todd J. Friends ,  Denis E. Ryono ,  Minsheng Zhang

Inventor： Todd J. Friends ,  Denis E. Ryono ,  Minsheng Zhang

IPC: C07C3700

CPC classification number: C07C233/27 ,  A61K31/167 ,  A61K45/06 ,  C07C233/25 ,  A61K2300/00

Abstract: New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH2—, —CO—, or —NH—; Y is —(CH2)n— where n is an integer from 1 to 5, or cis- or trans-ethylene; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R2 and R3 being other than hydrogen; R4 is hydrogen or lower alkyl; R5 is hydrogen or lower alkyl; R6 is carboxylic acid, or esters or prodrugs; R7 is hydrogen or an alkanoyl or an aroyl. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T3 regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.

Abstract translation: 提供了新的甲状腺受体配体，其具有以下通式：X是-O-，-S-，-CH 2 - ， - CO-或-NH-; Y是 - （CH 2）n - ，其中n是 1至5，或顺式或反式 - 亚乙基; R 1为卤素，三氟甲基，或1至6个碳原子的烷基或3至7个碳的环烷基; R 2和R 3相同或不同，为氢，卤素， 至4个碳或3至6个碳的环烷基，R2和R3中的至少一个不是氢; R4是氢或低级烷基; R5是氢或低级烷基; R6是羧酸或酯或前药; R7是氢 或烷酰基或芳酰基。此外，提供了用于预防，抑制或治疗与代谢功能障碍相关的疾病或取决于T3调节基因的表达的方法，其中如上所述的化合物以治疗 有效量。 与代谢功能障碍相关或依赖于T3调节基因的表达的这种疾病的实例包括肥胖症，高胆固醇血症，动脉粥样硬化，心律失常，抑郁症，骨质疏松症，甲状腺功能减退，甲状腺癌，青光眼，充血性心力衰竭和皮肤病 。

公开(公告)号：US06512149B2

公开(公告)日：2003-01-28

申请号：US09834335

申请日：2001-04-13

Applicant: Kazuhiko Yao ,  Mitsuhiro Higashi ,  Kenji Ekawa

Inventor： Kazuhiko Yao ,  Mitsuhiro Higashi ,  Kenji Ekawa

IPC: C07C3700

CPC classification number: C07C37/50 ,  C07C39/06 ,  C07C39/07

Abstract: By bringing a p-butylphenol compound or m-butylphenol compound in the gas phase into contact with a solid acid catalyst, i.e., a silica-alumina catalyst or alumina catalyst while heating, butyl groups are removed from the butylphenol compound and at the same time, highly purified isobutylene is recovered.

公开(公告)号：US06420613B1

公开(公告)日：2002-07-16

申请号：US09674960

申请日：2000-12-11

Applicant: Fumiaki Iwasaki ,  Yoshihiro Matsumura ,  Osamu Onomura ,  Kenji Tanaka

Inventor： Fumiaki Iwasaki ,  Yoshihiro Matsumura ,  Osamu Onomura ,  Kenji Tanaka

IPC: C07C3700

CPC classification number: C07C29/143 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/14 ,  C07C209/52 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C211/17 ,  C07C211/27 ,  C07C211/45 ,  C07C211/52 ,  C07C31/12 ,  C07C31/125 ,  C07C35/08 ,  C07C35/20 ,  C07C33/46 ,  C07C33/22 ,  C07C33/24 ,  C07C33/18 ,  C07C33/20 ,  C07C35/21 ,  C07C35/18

Abstract: A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy to handle, and a reducing agent therefor. A reduced product of an unsaturated organic compound is obtained by mixing the unsaturated organic compound and a trichlorosilane together to reduce the unsaturated organic compound in the presence of a compound that forms a silicon complex having five coordinations upon acting on the trichlorosilane such as an N-formylated product of a secondary amine having not less than 3 carbon atoms. The invention further provides a reducing agent comprising a particular silicon complex.

Abstract translation: 通过使用工业上廉价可利用并易于处理的三氯硅烷作为还原剂，有效还原不饱和有机化合物及其还原剂，制备还原产物的方法。 不饱和有机化合物的还原产物是通过将不饱和有机化合物和三氯硅烷混合在一起，在作用于三氯硅烷上的形成具有五个配位的硅配合物的化合物的存在下将不饱和有机化合物混合在一起， 具有不少于3个碳原子的仲胺的甲酰化产物。 本发明还提供了包含特定硅复合物的还原剂。

公开(公告)号：US06417410B1

公开(公告)日：2002-07-09

申请号：US09836216

申请日：2001-04-18

Applicant: Tomoyuki Suzuki ,  Fumisato Goto

Inventor： Tomoyuki Suzuki ,  Fumisato Goto

IPC: C07C3700

CPC classification number: C07C37/16 ,  Y02P20/544 ,  C07C39/07

Abstract: A method for producing ortho-alkylated phenols comprising reacting phenols represented by the general formula (1) with monohydric or dihydric alcohol in the presence of germanium oxide under conditions in which said alcohol is in the supercritical condition, wherein each of R1, R2, R3, R4 and R5 independently represents a hydrogen atom, or a linear or branched alkyl group having 1 to 10 carbon atoms.

公开(公告)号：US06265622B1

公开(公告)日：2001-07-24

申请号：US09259652

申请日：1999-02-26

Applicant: Terence Michael Barnhart

Inventor： Terence Michael Barnhart

IPC: C07C3700

CPC classification number: C07C37/58 ,  C07B41/02 ,  Y02P20/52 ,  C07C39/04

Abstract: A method and composition are disclosed for the hydroxylation of aromatic substrates in the presence of oxygen, hydrogen, and a catalyst. In a preferred embodiment, benzene is oxidized to phenol in the presence of oxygen, a vanadium catalyst, and hydrogen. The method is economical, safe, and amenable to commercial scale-up.

Abstract translation: 公开了在氧，氢和催化剂存在下芳族底物羟基化的方法和组合物。 在优选的实施方案中，在氧，钒催化剂和氢的存在下将苯氧化成苯酚。 该方法是经济，安全和易于商业化的。