公开(公告)号：US06232492B1

公开(公告)日：2001-05-15

申请号：US09380170

申请日：1999-08-25

Applicant: Juergen Stohrer

Inventor： Juergen Stohrer

IPC: C07C25906

CPC classification number: C07C259/06

Abstract: The invention relates to a method for preparing n-aryl-n-hydroxamides, whereby arylhydroxamines are reacted with ketones to n-aryl-n-hydroxamides, without using acyloxindoles-generating solvents.

Abstract translation: 本发明涉及一种制备正芳基 - 正羟基酰胺的方法，其中芳基羟胺与酮与N-芳基 - 正 - 羟基酰胺反应而不使用产生酰氧吲哚的溶剂。

公开(公告)号：US06710208B2

公开(公告)日：2004-03-23

申请号：US10107771

申请日：2002-03-27

Applicant: Joseph M. Salvino ,  George C. Morton ,  Helen J. Mason ,  Richard F. Labaudiniere

Inventor： Joseph M. Salvino ,  George C. Morton ,  Helen J. Mason ,  Richard F. Labaudiniere

IPC: C07C25906

CPC classification number: C07D307/33 ,  C07B2200/11 ,  C07C45/004 ,  C07C45/41 ,  C07C45/45 ,  C07C45/516 ,  C07C209/00 ,  C07C209/40 ,  C07C209/42 ,  C07C209/66 ,  C07C239/08 ,  C07C259/06 ,  C07C259/08 ,  C07C259/10 ,  C07C315/04 ,  C07D311/68 ,  C07D311/82 ,  C07D313/12 ,  C08F8/10 ,  C08F8/12 ,  C08F8/18 ,  C08F8/30 ,  C08F8/34 ,  C08F2800/20 ,  C08F2810/30 ,  C07C49/807 ,  C07C49/213 ,  C07C47/55 ,  C07C47/228 ,  C07C47/23 ,  C07C47/277 ,  C07C317/44 ,  C08F212/08 ,  C08F8/02 ,  C08F8/00

Abstract: This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

Abstract translation: 本发明涉及醛，酮，肟，胺，异羟肟酸和α，β-不饱和羧酸和醛化合物的固相合成方法以及用于其的聚合羟胺树脂化合物的方法。

公开(公告)号：US06576628B1

公开(公告)日：2003-06-10

申请号：US09486038

申请日：2000-07-06

Applicant: Frank Grams ,  Gerd Zimmermann ,  Hans-Willi Krell ,  Ernesto Menta ,  Herbert Leinert

Inventor： Frank Grams ,  Gerd Zimmermann ,  Hans-Willi Krell ,  Ernesto Menta ,  Herbert Leinert

IPC: C07C25906

CPC classification number: C07C259/06

Abstract: The invention relates to inhibitors of matrix metalloproteases, more specifically a 3-aryl-succinamido-hydroxamic acid of formula (I) and its salt, ester and derivative thereof, along with methods of producing a compound of formula (I) and pharmaceutical compositions thereof.

Abstract translation: 本发明涉及基质金属蛋白酶抑制剂，更具体地说是式（I）的3-芳基 - 琥珀酰氨基 - 异羟肟酸及其盐，酯和衍生物，以及制备式（I）化合物及其药物组合物的方法 。

公开(公告)号：US06610729B1

公开(公告)日：2003-08-26

申请号：US09701043

申请日：2000-11-22

Applicant: Tomokazu Gotou ,  Shinji Takeda ,  Kazuhiro Maeda ,  Tomohiro Yoshida ,  Naoki Sugiyama ,  Tadahiro Takemoto

Inventor： Tomokazu Gotou ,  Shinji Takeda ,  Kazuhiro Maeda ,  Tomohiro Yoshida ,  Naoki Sugiyama ,  Tadahiro Takemoto

IPC: C07C25906

CPC classification number: C07D209/48 ,  C07C259/06 ,  C07D209/46 ,  C07D233/72 ,  C07D307/52 ,  C07D309/12 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to a hydroxamic acid derivative of the formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition containing the derivative or a salt thereof, and to pharmaceutical use thereof. The hydroxamic acid derivative and a pharmacologically acceptable salt thereof of the present invention have an inhibitory activity of TNF &agr; production, and are useful for, for example, the prophylaxis and treatment of the diseases such as autoimmune diseases and inflammatory diseases (e.g., sepsis, MOF, rheumatoid arthritis, Crohn's disease, cachexia, myasthenia gravis, systemic lupus erythematosus, asthma, I type diabetes, psoriasis and the like), and the like.

Abstract translation: 本发明涉及式（I）的异羟肟酸衍生物，其中各符号如说明书中所定义，其药理学上可接受的盐，含有其衍生物或其盐的药物组合物及其药学用途。 本发明的异羟肟酸衍生物及其药理学上可接受的盐具有TNFα产生的抑制活性，可用于例如自身免疫性疾病和炎症性疾病（例如败血症， MOF，类风湿关节炎，克罗恩病，恶病质，重症肌无力，系统性红斑狼疮，哮喘，I型糖尿病，牛皮癣等）等。

公开(公告)号：US06495719B2

公开(公告)日：2002-12-17

申请号：US09812944

申请日：2001-03-27

Applicant: Hsuan-Yin Lan-Hargest ,  Robert J. Kaufman ,  Norbert L. Wiech

Inventor： Hsuan-Yin Lan-Hargest ,  Robert J. Kaufman ,  Norbert L. Wiech

IPC: C07C25906

CPC classification number: C07C57/42 ,  A61K31/16 ,  C07C57/60 ,  C07C259/06 ,  C07D307/54

Abstract: Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Inhibition of histone deacetylase can lead to the histone deacetylase-mediated transcriptional repression of tumor suppressor genes. For example, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, such as hematopoiesis, and genetic related metabolic disorders, such as, cystic fibrosis and adrenoleukodystrophy.

公开(公告)号：US06350902B2

公开(公告)日：2002-02-26

申请号：US09822945

申请日：2001-03-30

Applicant: David R. Hill ,  Chi-Nung Hsiao ,  Ravi Kurukulasuriya ,  Steve Wittenberger

Inventor： David R. Hill ,  Chi-Nung Hsiao ,  Ravi Kurukulasuriya ,  Steve Wittenberger

IPC: C07C25906

CPC classification number: C07C259/06 ,  C07D233/74 ,  C07D317/28

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

Abstract translation: 本发明提供了N-羟胺的选择性N-甲酰化的方法。