公开(公告)号：US06761737B2

公开(公告)日：2004-07-13

申请号：US10017915

申请日：2001-12-11

Applicant: Gholam-Reza Zadno-Azizi ,  Tuan Anh Nguyen ,  Valdemar Portney ,  Albert C. Ting

Inventor： Gholam-Reza Zadno-Azizi ,  Tuan Anh Nguyen ,  Valdemar Portney ,  Albert C. Ting

IPC: A61F214

CPC classification number: A61F2/1613 ,  A61F2/15 ,  A61F2/1629 ,  A61F2/1648 ,  B29D11/023 ,  B29D11/026 ,  Y10S623/907

Abstract: There is disclosed an accommodating intraocular lens for implantation in an eye having an optical axis. The lens comprises an anterior portion which in turn comprises an anterior viewing element and an anterior biasing element. The lens further comprises a posterior portion which in turn comprises a posterior viewing element in spaced relationship to the anterior viewing element and a posterior biasing element. The anterior portion and posterior portion meet at first and second apices of the intraocular lens. The anterior portion and the posterior portion and/or the apices are responsive to force thereon to cause the separation between the viewing elements to change. Additional embodiments and methods are also disclosed.

Abstract translation: 公开了一种用于植入具有光轴的眼睛中的适应性眼内透镜。 透镜包括前部，前部又包括前部观察元件和前部偏置元件。 透镜还包括后部，后部又包括与前视觉元件间隔开的后视元件和后偏置元件。 前部和后部在眼内透镜的第一和第二顶点相交。 前部和后部和/或顶点响应于其上的力而导致观察元件之间的分离改变。 还公开了另外的实施例和方法。

公开(公告)号：US06755858B1

公开(公告)日：2004-06-29

申请号：US09545532

申请日：2000-04-07

Applicant: Thomas C. White

Inventor： Thomas C. White

IPC: A61F214

CPC classification number: A61F2/142 ,  A61F2220/005 ,  A61F2250/0069 ,  A61L24/04 ,  G02C7/02

Abstract: An implantable keratoprosthesis having a central lenticule and a peripheral annulus of corneal tissue. The keratoprosthesis includes a transparent polymeric lenticule having an elongated stem with a generally cylindrical outer surface and a central axis. On one end thereof, the stem carries a dome having a peripheral skirt extending outwardly from the axis beyond the cylindrical surface of the stem. An annulus of corneal tissue has a central bore within which the stem is received, the peripheral skirt contacting and overlying a portion of the corneal annulus adjacent the bore. A portion of the annulus extends outwardly beyond the peripheral skirt for attachment to a surgically prepared cornea. A ring of polymeric material is received over the stem to capture between the ring and the skirt the corneal annulus. The ring is attached to the stem, as by welding and/or by use of a tissue-adherent, biologically acceptable adhesive disposed between the cylindrical surface of the stem and the bore of the annulus to form a strong, liquid-tight seal between the stem and annulus.

Abstract translation: 具有中心微透镜和角膜组织的外周环的可植入角膜假体。 角膜假体包括透明聚合物微透镜，其具有带有大致圆柱形外表面和中心轴线的细长柄。 在其一端，所述杆带有圆顶，所述圆顶具有从所述轴向外延伸超过所述杆的圆柱形表面的周边裙部。 角膜组织的环带具有中心孔，杆在其中被容纳，周边裙部接触并覆盖邻近孔的角膜环的一部分。 环的一部分向外延伸超出周边裙部以附接到手术准备的角膜。 聚合物材料环被容纳在杆上以在环和裙部之间捕获角膜环。 通过焊接和/或通过使用设置在杆的圆柱形表面和环的孔之间的组织粘附的生物可接受的粘合剂将环连接到杆上，以在所述杆之间形成牢固的液密密封 茎和环。

公开(公告)号：US06740116B2

公开(公告)日：2004-05-25

申请号：US10148117

申请日：2002-05-24

Applicant: Olaf Morcher

Inventor： Olaf Morcher

IPC: A61F214

CPC classification number: A61F2/1613

Abstract: A foldable intraocular lens with an iris diaphragm (2) for covering an aniridia. The iris diaphragm can thus be based upon a natural iris. The diaphragm essentially comprises a film, printed with a pigment, provided with a sealing layers and completely embedded in the transparent lens material.

Abstract translation: 一种具有用于覆盖aniridia的虹膜隔膜（2）的可折叠眼内透镜。 因此，虹膜隔膜可以基于天然虹膜。 隔膜基本上包括印刷有颜料的膜，其设置有密封层并且完全嵌入透明透镜材料中。

公开(公告)号：US06669950B2

公开(公告)日：2003-12-30

申请号：US10187006

申请日：2002-07-01

Applicant: Yoseph Yaacobi

Inventor： Yoseph Yaacobi

IPC: A61F214

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/00781

Abstract: The present invention is directed to a drug delivery device for a human eye. The human eye has a sclera, an inferior oblique muscle, and a macula. The device of the present invention includes a pharmaceutically active agent, and a geometry that facilitates the implantation of the device on an outer surface of the sclera, beneath the inferior oblique muscle, and with the pharmaceutically active agent disposed above the macula. Methods of delivery a pharmaceutically active agent to the posterior segment of the human eye are also disclosed.

公开(公告)号：US06544286B1

公开(公告)日：2003-04-08

申请号：US09618580

申请日：2000-07-18

Applicant: Edward Perez

Inventor： Edward Perez

IPC: A61F214

CPC classification number: A61L27/3604 ,  A61F2/142 ,  A61F2/145 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/3813 ,  A61L27/3839 ,  A61L2430/16

Abstract: This invention relates to a contact lens made of donor corneal tissue, to a method of preparing that lens, and to a technique of placing the lens on the eye. The lens is made of donor corneal tissue that is acellularized by removing native epithelium and keratocytes. These cells are replaced with human epithelium and keratocytes to form a lens that has a structural anatomy similar to human cornea. The ocular lens is used to correct conditions such as astigmatism, myopia, aphakia, and presbyopia.

Abstract translation: 本发明涉及一种由供体角膜组织制成的隐形眼镜，一种制备该镜片的方法，以及将该镜片放置在眼睛上的技术。 透镜由供体角膜组织制成，通过去除天然上皮细胞和角质细胞而脱细胞。 这些细胞被人上皮细胞和角膜细胞代替，以形成具有与人类角膜相似的结构解剖学的晶状体。 眼镜用于矫正散光，近视，无晶状体和老花眼等症状。

公开(公告)号：US06514518B2

公开(公告)日：2003-02-04

申请号：US09932245

申请日：2001-08-17

Applicant: Donald Monkhouse ,  Jaedeok Yoo ,  Jill K. Sherwood ,  Michael J. Cima ,  Esteban Bornancini

Inventor： Donald Monkhouse ,  Jaedeok Yoo ,  Jill K. Sherwood ,  Michael J. Cima ,  Esteban Bornancini

IPC: A61F214

CPC classification number: A61K9/0024 ,  A61F2/02 ,  A61F2/28 ,  A61F2/3094 ,  A61F2002/009 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/30932 ,  A61F2002/30962 ,  A61F2210/0004 ,  A61F2230/0063 ,  A61F2240/001 ,  A61F2250/003 ,  A61F2250/0067 ,  A61K9/0051 ,  A61K9/14 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/20 ,  A61K9/2086 ,  A61K9/2095 ,  B29C64/00 ,  B29C64/165 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

Abstract: Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.

公开(公告)号：US06416777B1

公开(公告)日：2002-07-09

申请号：US09664790

申请日：2000-09-19

Applicant: Yoseph Yaacobi

Inventor： Yoseph Yaacobi

IPC: A61F214

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/00781

Abstract: The present invention is directed to a drug delivery device for a human eye. The human eye has a sclera, an inferior oblique muscle, and a macula. The device of the present invention includes a pharmaceutically active agent, and a geometry that facilitates the implantation of the device on an outer surface of the sclera, beneath the inferior oblique muscle, and with the pharmaceutically active agent disposed above the macula. Methods of delivery a pharmaceutically active agent to the posterior segment of the human eye are also disclosed.

Abstract translation: 本发明涉及用于人眼的药物递送装置。 人眼有巩膜，下斜肌和黄斑。 本发明的装置包括药物活性剂和有利于将装置植入巩膜外表面，下斜肌下面以及配置在黄斑之上的药物活性剂的几何形状。 还公开了将药物活性剂递送至人眼后段的方法。

公开(公告)号：US06187041B1

公开(公告)日：2001-02-13

申请号：US09224446

申请日：1998-12-31

Applicant: Scott N. Garonzik

Inventor： Scott N. Garonzik

IPC: A61F214

CPC classification number: A61F2/141

Abstract: An ocular replacement system provides a ball-shaped implant body having an outer spherical and porous surface that is receptive to ingrowth of ocular tissue and including an anterior portion positioned forwardly when the implant is fitted in the eye cavity to create a convex tissue surface area when covered by conjunctiva. A prosthesis includes an outer face and an opposite inner concave surface shaped to conform generally to the convex tissue surface area. When fitted in the front orbital space of the eye cavity, a magnetic attractive force between at least one magnet on the inner surface of the prosthesis and one or more magnetically attractive elements on the anterior portion of the implant couples the prosthesis to the implant so that the prosthesis follows movement of the implant to simulate natural eye movement within the eye cavity. The magnets are offset relative to the attractive elements to avoid direct alignment and excessive magnetic attraction, thereby reducing pressure which may cause tissue breakdown, infection, tissue dehiscence or implant extrusion.

Abstract translation: 眼睛替换系统提供了球形植入体，其具有外接球形和多孔表面，该外表面和多孔表面可接受眼组织的向内生长，并且当植入物安装在眼腔中时包括位于前方的前部，以产生凸组织表面积， 被结膜覆盖 假体包括外表面和相对的内凹表面，其形状大致符合凸组织表面区域。 当安装在眼腔的前部轨道空间中时，假体内表面上的至少一个磁体与植入物前部上的一个或多个吸引力元件之间的磁吸引力将假体联接到植入物，使得 该假体遵循植入物的运动以模拟眼睛腔内的自然眼睛运动。 磁体相对于有吸引力的元件偏移，以避免直接对准和过度的磁吸引，从而降低可能导致组织破裂，感染，组织裂开或植入物挤出的压力。

公开(公告)号：US06814755B2

公开(公告)日：2004-11-09

申请号：US10296773

申请日：2002-12-13

Applicant: Emmanuel LaCombe ,  Jean-Marie Parel ,  Bernard Duchesne ,  Franck Villain

Inventor： Emmanuel LaCombe ,  Jean-Marie Parel ,  Bernard Duchesne ,  Franck Villain

IPC: A61F214

CPC classification number: A61F2/142

Abstract: A synthetic cornea for placing in a recess formed in the cornea, the recess opening out into the anterior face of the cornea so as to leave Descemet's membrane intact. The synthetic cornea comprises a piece (42) of flexible transparent material having an axis of circular symmetry and presenting an anterior face (44) in the form of a spherical cap of radius Ra and a posterior face (46) in the form of a spherical cap of radius Rp, the central zones of the two faces being separated by a distance e, and a side wall (48) substantially in the form of a truncated cone whose axis coincides with the axis of symmetry and whose apex lies in front of the anterior face, the angle a made between the section of the side wall and the section of the posterior face in a section plane containing the axis of revolution being less than or equal to 45°.

Abstract translation: 一种用于放置在形成在角膜中的凹部中的合成角膜，该凹陷开口到角膜的前表面，以使得Descemet的膜完好无损。 合成角膜包括具有圆形对称轴的柔性透明材料的片（42），并且具有半径为Ra的球形帽形式的前表面（44）和呈球形形状的后表面（46） 半径Rp的帽，两个面的中心区域被分隔开距离e，以及基本上呈截头圆锥形状的侧壁（48），其轴线与对称轴线重合，并且其顶点位于 前面，在包含旋转轴线的剖面中，侧壁部分与后面部分之间形成的角度α小于或等于45°。

公开(公告)号：US06767934B1

公开(公告)日：2004-07-27

申请号：US09936647

申请日：2002-02-25

Applicant: Kenneth A. Hodd ,  Keith Alfred Dillingham

Inventor： Kenneth A. Hodd ,  Keith Alfred Dillingham

IPC: A61F214

CPC classification number: G02B1/043 ,  C08F2/48 ,  C08F8/40 ,  C08F230/02 ,  C08G77/38 ,  Y10S522/905

Abstract: Macromolecular photocrosslinkers have polymeric backbones of substituted siloxane groups carrying photoactive groups. When exposed to light of wavelength above 305 nm, the photocrosslinkers are adapted to generate radicals which are retained on the macromolecular photocrosslinker and react to form a crosslinked network structure. The photocrosslinkers may be used in the production of medical devices, including ophthalmic lenses.

Abstract translation: 高分子光交联剂具有带有光活性基团的取代的硅氧烷基团的聚合物主链。 当暴露于波长高于305nm的光时，光交联剂适于产生保留在大分子光交联剂上的自由基，并反应形成交联网络结构。 光致交联剂可以用于生产医疗装置，包括眼科镜片。