公开(公告)号：US20240255465A1

公开(公告)日：2024-08-01

申请号：US18629616

申请日：2024-04-08

Applicant: EMD Millipore Corporation

Inventor： Harry Lee ,  Kevin Shao-Kwan Lee

IPC: G01N27/416 ,  G01D18/00 ,  G01N33/00 ,  G05D21/02

CPC classification number: G01N27/4165 ,  G01N33/004 ,  G05D21/02 ,  G01D18/008

Abstract: Methods of calibrating a pH sensor fixed within an enclosed vessel are disclosed. The methods include introducing a buffer into the enclosed vessel, introducing a gas mixture comprising CO2 into the enclosed vessel, measuring a pH signal of the solution, measuring a CO2 concentration of a headspace gas of the solution, and calculating a pH value with a buffer calibration curve. The methods include calculating a calibration parameter with a sensor calibration curve and calibrating the pH sensor with the calibration parameter. Reactor systems are also disclosed. The systems include an enclosed reactor, a pH sensor, a CO2 sensor, a temperature control subsystem, and a controller. Methods of facilitating pH sensor calibration without sampling in a bioreactor system are also disclosed. The methods include providing a controller and providing instructions to operably connect the controller to the pH sensor and the CO2 sensor.

公开(公告)号：US12031941B2

公开(公告)日：2024-07-09

申请号：US16992054

申请日：2020-08-12

Applicant: ERBI BIOSYSTEMS, INC.

Inventor： Harry Lee ,  Kevin Shao-Kwan Lee

IPC: G01N27/416 ,  G01N33/00 ,  G05D21/02 ,  G01D18/00

CPC classification number: G01N27/4165 ,  G01N33/004 ,  G05D21/02 ,  G01D18/008

Abstract: Methods of calibrating a pH sensor fixed within an enclosed vessel are disclosed. The methods include introducing a buffer into the enclosed vessel, introducing a gas mixture comprising CO2 into the enclosed vessel, measuring a pH signal of the solution, measuring a CO2 concentration of a headspace gas of the solution, and calculating a pH value with a buffer calibration curve. The methods include calculating a calibration parameter with a sensor calibration curve and calibrating the pH sensor with the calibration parameter. Reactor systems are also disclosed. The systems include an enclosed reactor, a pH sensor, a CO2 sensor, a temperature control subsystem, and a controller. Methods of facilitating pH sensor calibration without sampling in a bioreactor system are also disclosed. The methods include providing a controller and providing instructions to operably connect the controller to the pH sensor and the CO2 sensor.

公开(公告)号：US11913902B2

公开(公告)日：2024-02-27

申请号：US17093324

申请日：2020-11-09

Applicant: SMARTWASH SOLUTIONS, LLC

Inventor： James M. Brennan ,  Eric Child Wilhelmsen ,  Danny Elmer Lindstrom ,  Christopher Michael McGinnis

IPC: A23N12/02 ,  G01N27/416

CPC classification number: G01N27/4165 ,  A23N12/02 ,  G01N27/4163 ,  G01N27/4166 ,  G01N27/4167

Abstract: A food wash reference fluid delivery apparatus includes a portable reference fluid reservoir comprising an inlet and an outlet and configured to store a reference fluid that includes a predetermined concentration of an analyte, a pump fluidly coupled to the outlet of the portable reference fluid reservoir and configured to pump the reference fluid from the outlet of the portable reference fluid reservoir, a sensor connector configured to fluidly couple with a sensor positioned along a fluid flow path of the food wash system, a sensor fluid line configured to provide the reference fluid from the pump to the sensor connector, an inlet fluid line configured to provide the reference fluid from the pump to the inlet of the portable reference fluid reservoir, and a valve configured to adjustably control a fluid flow rate of the reference fluid through the sensor fluid line and the inlet fluid line.

公开(公告)号：US11768173B2

公开(公告)日：2023-09-26

申请号：US18125811

申请日：2023-03-24

Applicant: Onset Computer Corporation

Inventor： Jacob Lacourse ,  Frederick Sonnichsen

IPC: G01N27/416 ,  B08B13/00 ,  B08B3/00

CPC classification number: G01N27/4167 ,  B08B3/00 ,  G01N27/4165

Abstract: A self-vibrating pH probe comprise a housing containing an electronic assembly to which is coupled a vibration source element so that at least a portion of vibrations caused by the vibration source element propagate to the electronic assembly, the vibration source element being controllable for at least on/off operation. The self-vibrating pH probe further comprising a pH probe member having a probe tip at a first end, the probe member extending from the housing and mechanically and electrically coupled by a second end to the electronic assembly so that at least a portion of vibrations propagating to the electronic assembly further propagate to the probe tip; and further including a processor coupled to the electronic assembly for coordinating operation of the vibration source element and operation of the pH probe member.

公开(公告)号：US20180073354A1

公开(公告)日：2018-03-15

申请号：US15563626

申请日：2016-04-04

Applicant: Schlumberger Technology Corporation

Inventor： Amanda Olivio ,  Gary A. Hazen ,  Fernando Garcia-Osuna ,  Robert Monroe Lowe, Jr. ,  Jason Guernsey ,  Tao Xu ,  Michael C. Sakach ,  Mark A. Fredette ,  Ricardo Y. Torres ,  Arturo Mejia ,  Mia Pommier

IPC: E21B47/12 ,  E21B47/01 ,  G01V3/30

CPC classification number: E21B47/122 ,  E21B47/011 ,  G01N27/302 ,  G01N27/4165 ,  G01N31/02 ,  G01R27/00 ,  G01V3/30

Abstract: A tool for use in a borehole in a geological formation may include a chassis, a drill collar surrounding the chassis, a port plug coupled between the drill collar and the chassis, RF antennas carried by the drill collar, and a multi-chip module (MCM) electronics package(s). The electronics package(s) may include a hermetically sealed electronics housing positioned between the chassis and the drill collar, a substrate within the electronics housing, RF transmitter circuitry on the substrate to cooperate with at least one first RF antenna to transmit RF signals into the geological formation, and RF receiver circuitry on the substrate to cooperate with at least one second RF antenna to receive RF signals from the geological formation. Furthermore, an electronics housing mount may couple the electronics housing with the port plug, and the electronics housing mount may have a passageway extending therethrough for receiving the port plug.

公开(公告)号：US20160349209A1

公开(公告)日：2016-12-01

申请号：US15233392

申请日：2016-08-10

Applicant: Honeywell International Inc.

Inventor： Donald Horkheimer

IPC: G01N27/414 ,  G01N27/416

CPC classification number: G01N27/4148 ,  G01N27/414 ,  G01N27/4165 ,  G01N27/4167 ,  G01N27/4168

Abstract: An ion sensor apparatus comprises at least one ion sensitive field effect transistor (ISFET) device configured to be exposed to a liquid, a reference electrode configured to contact the liquid to which the ISFET device is exposed, and at least one magnet configured to intermittently expose the ISFET device to a magnetic field. A processor is operatively connected to the ISFET device and the reference electrode. The processor modulates the magnetic field to produce a corresponding modulated output in resistance of the ISFET device, and modulation of a reported output value of the ion sensor apparatus.

公开(公告)号：US20150355134A1

公开(公告)日：2015-12-10

申请号：US14763252

申请日：2014-01-24

Applicant: VEOLIA WATER SOLUTIONS & TECHNOLOGIES SUPPORT

Inventor： Yves DE COULON ,  Carine BERIET ,  Cyrille LEMOINE

IPC: G01N27/333 ,  G01N27/416 ,  G01N27/30

CPC classification number: G01N27/3335 ,  G01N27/302 ,  G01N27/414 ,  G01N27/4165

Abstract: The invention concerns a device for measuring the pH of an effluent, said device comprising means for measuring an item of information representative of the pH of said effluent intended to be brought into contact with said effluent.According to the invention, such a device further comprises means for modifying the pH value of said effluent close to said means for measuring.

Abstract translation: 本发明涉及一种用于测量流出物的pH值的装置，所述装置包括用于测量表示所述流出物的pH值以与所述流出物接触的信息项的装置。 根据本发明，这种装置还包括用于改变靠近所述测量装置的所述流出物的pH值的装置。

公开(公告)号：US20140200842A1

公开(公告)日：2014-07-17

申请号：US14238423

申请日：2012-08-09

Applicant: Fumihiro Dasai ,  Kazuaki Sawada ,  Hirokazu Nakazawa

Inventor： Fumihiro Dasai ,  Kazuaki Sawada ,  Hirokazu Nakazawa

IPC: G01N27/416 ,  G01R35/00

CPC classification number: G01N27/4165 ,  G01R35/005

Abstract: Provided is a device adapted for detecting chemical and physical phenomena and suitable for high integration, and a method for controlling the detection device. When a plurality of pH-detecting devices are used, a variation in sensitivity occurs in each of the sensing units. The variation in sensitivity can be calibrated using a simple method. The amount of charge (output signal) delivered by each of the sensing units to a standard solution is determined, and the difference between the delivered charge amount and a standard charge amount (standard output signal) delivered by a standard sensing unit is determined. The capacity of the potential well of the sensing unit is changed, or the potential of a TG unit when a charge is delivered is changed, so as to cancel out the difference.

Abstract translation: 提供了一种适于检测化学和物理现象并适合于高集成度的装置，以及用于控制检测装置的方法。 当使用多个pH检测装置时，灵敏度的变化发生在每个感测单元中。 灵敏度的变化可以使用简单的方法进行校准。 确定由感测单元传送到标准溶液的电荷量（输出信号），并且确定传送的电荷量与由标准感测单元传送的标准电荷量（标准输出信号）之间的差异。 改变感测单元的电位阱的容量，或者改变发送电荷时的TG单元的电位，以消除差异。

公开(公告)号：US08776573B2

公开(公告)日：2014-07-15

申请号：US13333602

申请日：2011-12-21

Applicant: Todd Rearick ,  Melville Davey ,  Mark Beauchemin

Inventor： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

IPC: G01N21/00

CPC classification number: G01N27/4165 ,  G01N27/4145 ,  G06F19/22

Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

Abstract translation: 提供了一种方法，计算机程序产品和系统来校准具有多个传感器的传感器阵列。 该方法可以包括将参考电极的电压从第一电压扫描到第二电压，其中参考电极与传感器阵列流体连通。 可以在第一和第二电压内的一个或多个电压监视多个传感器中的每一个的输出电压。 可以在一个或多个电压中的每一个处计算多个传感器的总体平均增益。 此外，可以确定传感器阵列的采集窗口。 采集窗口可以包括在特定参考电极电压下提供最大总平均增益的传感器的最大分布。

公开(公告)号：US20130288359A1

公开(公告)日：2013-10-31

申请号：US13930180

申请日：2013-06-28

Applicant: HAMILTON BONADUZ AG

Inventor： Andreas LOEBBERT ,  Dirk SCHOENFUSS

IPC: G01N33/84

CPC classification number: G01N33/00 ,  C12M23/26 ,  C12M23/28 ,  C12M41/26 ,  C12M41/32 ,  C12M41/34 ,  C12M41/36 ,  C12M41/40 ,  G01N27/283 ,  G01N27/4165 ,  G01N33/84

Abstract: The invention relates to a reaction vessel with a sensor unit. The reaction vessel comprising a reaction space configured to be connected with the sensor unit that comprises at least one sensor device configured to be calibrated, at least one compartment containing a calibrating agent, and a housing. The sensor unit is arranged to calibrate the at least one sensor device by contact with the calibrating agent before chemical or physical parameters of a measurement substance are measured, wherein the at least one sensor device is further configured such that the relative movement between the at least one sensor device and the at least one compartment is irreversible. The at least one sensor device is movable relative to the at least one compartment from an initial position into a measurement readiness position. The reaction vessel and the sensor unit can be sterilised or are sterilised jointly.

Abstract translation: 本发明涉及具有传感器单元的反应容器。 反应容器包括构造成与传感器单元连接的反应空间，该反应空间包括被配置为校准的至少一个传感器装置，包含校准剂的至少一个隔室和壳体。 所述传感器单元布置成在测量所述测量物质的化学或物理参数之前通过与所述校准剂接触来校准所述至少一个传感器装置，其中所述至少一个传感器装置还被配置为使得所述至少一个传感器装置 一个传感器装置和至少一个隔室是不可逆的。 所述至少一个传感器装置可相对于至少一个隔室从初始位置移动到测量准备位置。 反应容器和传感器单元可以灭菌或联合灭菌。