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公开(公告)号：US09677091B2
公开(公告)日：2017-06-13
申请号：US14489813
申请日：2014-09-18
发明人： Joerg Bohlmann , Philipp Zerbe
IPC分类号： C12P7/02 , C07H21/04 , C12N15/52 , C12N1/20 , C12N1/16 , C12N15/81 , C12N15/70 , C12N9/88 , C07D307/77 , C12P15/00 , C07D307/92
CPC分类号： C12P7/02 , C07D307/77 , C07D307/92 , C12N1/16 , C12N1/20 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/81 , C12P15/00 , C12Y402/03 , C12Y402/03018 , C12Y402/03032
摘要： Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.
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公开(公告)号：US08889381B2
公开(公告)日：2014-11-18
申请号：US13694350
申请日：2012-11-21
申请人： Joerg Bohlmann , Philipp Zerbe
发明人： Joerg Bohlmann , Philipp Zerbe
CPC分类号： C12P7/02 , C07D307/77 , C07D307/92 , C12N1/16 , C12N1/20 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/81 , C12P15/00 , C12Y402/03 , C12Y402/03018 , C12Y402/03032
摘要： Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.
摘要翻译： 本文提供了双萜合酶（diTPS）和用于产生二萜类化合物的方法。 本文还提供了编码diTPS，diTPS氨基酸序列，diTPS蛋白，载体，细胞，转基因生物，用途，组合物，方法，方法和试剂盒的核酸序列。
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公开(公告)号：US20130224809A1
公开(公告)日：2013-08-29
申请号：US13694350
申请日：2012-11-21
申请人： Joerg Bohlmann , Philipp Zerbe
发明人： Joerg Bohlmann , Philipp Zerbe
IPC分类号： C12N9/88
CPC分类号： C12P7/02 , C07D307/77 , C07D307/92 , C12N1/16 , C12N1/20 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/81 , C12P15/00 , C12Y402/03 , C12Y402/03018 , C12Y402/03032
摘要： Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.
摘要翻译： 本文提供了双萜合酶（diTPS）和用于产生二萜类化合物的方法。 本文还提供了编码diTPS，diTPS氨基酸序列，diTPS蛋白，载体，细胞，转基因生物，用途，组合物，方法，方法和试剂盒的核酸序列。
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公开(公告)号：US11993635B2
公开(公告)日：2024-05-28
申请号：US17816937
申请日：2022-08-02
发明人： Jerome Fox , Ankur Sarkar , Akarawin Hongdusit , Edward Kim
IPC分类号： C12N1/20 , C07K14/005 , C07K14/47
CPC分类号： C07K14/005 , C07K14/47 , C12N1/20 , C07K2319/80 , C12Y205/01001 , C12Y205/0101 , C12Y207/01036 , C12Y207/04002 , C12Y301/01048 , C12Y401/01033 , C12Y402/03017 , C12Y402/03018 , C12Y402/03024 , C12Y402/03056 , C12Y503/03002
摘要： This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling.
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公开(公告)号：US20150037854A1
公开(公告)日：2015-02-05
申请号：US14489813
申请日：2014-09-18
申请人： Joerg Bohlmann , Philipp Zerbe
发明人： Joerg Bohlmann , Philipp Zerbe
CPC分类号： C12P7/02 , C07D307/77 , C07D307/92 , C12N1/16 , C12N1/20 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/81 , C12P15/00 , C12Y402/03 , C12Y402/03018 , C12Y402/03032
摘要： Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.
摘要翻译： 本文提供了双萜合酶（diTPS）和用于产生二萜类化合物的方法。 本文还提供了编码diTPS，diTPS氨基酸序列，diTPS蛋白，载体，细胞，转基因生物，用途，组合物，方法，方法和试剂盒的核酸序列。
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公开(公告)号：US20240199704A1
公开(公告)日：2024-06-20
申请号：US18443086
申请日：2024-02-15
发明人： Jerome FOX , Ankur SARKAR , Akarawin HONGDUSIT , Edward KIM
IPC分类号： C07K14/005 , C07K14/47 , C12N1/20
CPC分类号： C07K14/005 , C07K14/47 , C12N1/20 , C07K2319/80 , C12Y205/01001 , C12Y205/0101 , C12Y207/01036 , C12Y207/04002 , C12Y301/01048 , C12Y401/01033 , C12Y402/03017 , C12Y402/03018 , C12Y402/03024 , C12Y402/03056 , C12Y503/03002
摘要： This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling.
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公开(公告)号：US20230151354A1
公开(公告)日：2023-05-18
申请号：US17859509
申请日：2022-07-07
发明人： Jerome FOX , Ankur SARKAR
CPC分类号： C12N15/1055 , C12N15/70 , C12P5/007 , C12N15/52 , C12Y205/01029 , C12N9/88 , C12Y402/03018 , C12Y402/03038 , C12Y402/03017
摘要： The disclosure provides systems, methods, reagents, apparatuses, vectors, and host cells for the discovery and evolution of metabolic pathways that produce small molecules that modulate enzyme function.
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公开(公告)号：US20230151062A1
公开(公告)日：2023-05-18
申请号：US17816937
申请日：2022-08-02
发明人： Jerome FOX , Ankur SARKAR , Akarawin HONGDUSIT , Edward KIM
IPC分类号： C07K14/005 , C07K14/47 , C12N1/20
CPC分类号： C07K14/005 , C07K14/47 , C12N1/20 , C07K2319/80 , C12Y205/01001 , C12Y205/0101 , C12Y207/01036 , C12Y207/04002 , C12Y301/01048 , C12Y401/01033 , C12Y402/03017 , C12Y402/03018 , C12Y402/03024 , C12Y402/03056 , C12Y503/03002
摘要： This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling.
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公开(公告)号：US20170321230A1
公开(公告)日：2017-11-09
申请号：US15588678
申请日：2017-07-18
发明人： Joerg Bohlmann , Philipp Zerbe
IPC分类号： C12P7/02 , C12P15/00 , C12N15/81 , C07D307/92 , C12N15/52 , C12N9/88 , C12N1/20 , C12N1/16 , C12N15/70 , C07D307/77
CPC分类号： C12P7/02 , C07D307/77 , C07D307/92 , C12N1/16 , C12N1/20 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/81 , C12P15/00 , C12Y402/03 , C12Y402/03018 , C12Y402/03032
摘要： Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.
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