公开(公告)号：US20160177328A1

公开(公告)日：2016-06-23

申请号：US14785665

申请日：2014-04-17

申请人： BASE PLANT SCIENCE COMPANY GMBH

发明人： Yves Hatzfeld ,  Jonathan R. HOWARTH ,  Malcolm J. HAWKESFORD

IPC分类号： C12N15/82 ,  C12N9/90 ,  C12N9/02

CPC分类号： C12N15/8261 ,  C07K14/415 ,  C12N9/0036 ,  C12N9/90 ,  C12N15/8271 ,  C12N15/8273 ,  C12Y106/05005 ,  C12Y106/99 ,  C12Y502/01008 ,  Y02A40/146

摘要： A method for enhancing various economically important yield-related traits in plants. A method for enhancing one or more yield-related traits in plants by modulating expression in plants of a nucleic acid encoding a FKBP 16-3 (FK506-binding protein) or a quinone reductase-related (QRR) polypeptide. Plants having modulated expression of a nucleic acid encoding a FKBP 16-3 or a QRR polypeptide, which plants have one or more enhanced yield-related traits compared to control plants. FKBP 16-3 encoding and QRR nucleic acids, and constructs comprising the same, useful in performing the methods.

摘要翻译： 一种增强植物中各种经济上重要的产量相关性状的方法。 通过调节编码FKBP 16-3（FK506结合蛋白）或醌还原酶相关（QRR）多肽的核酸的植物中的表达来增强植物中一种或多种产量相关性状的方法。 已经调节了编码FKBP 16-3或QRR多肽的核酸表达的植物，与对照植物相比，植物具有一个或多个增强的产量相关性状。 FKBP 16-3编码和QRR核酸，以及包含其的构建体，可用于实施方法。

公开(公告)号：US20170081669A1

公开(公告)日：2017-03-23

申请号：US15126291

申请日：2015-03-18

申请人： Carmel-Haifa University Economic Corp. Ltd

发明人： Kobi ROSENBLUM ,  Akiva RAPPAPORT

IPC分类号： C12N15/113 ,  A61K31/255 ,  A61K31/4375

CPC分类号： C12N15/1137 ,  A61K31/165 ,  A61K31/255 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4375 ,  A61K31/455 ,  A61K31/7064 ,  A61K31/7105 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y106/05005

摘要： An active agent capable of reducing quinone reductase 2 activity, for use in improvement of cognition in a subject is provided. Such an active agent may be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A vector comprising a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 and a pharmaceutical composition comprising an active agent capable of reducing quinone reductase 2 activity or said vector are provided as well.

公开(公告)号：US11692208B2

公开(公告)日：2023-07-04

申请号：US17947048

申请日：2022-09-16

申请人： ZYMOCHEM, INC.

发明人： Harshal Akshay Chokhawala ,  Jonathan Kuchenreuther ,  Jorge Alonso-Gutiérrez ,  Yi-Shu Tai

IPC分类号： C12N1/20 ,  C12N15/52 ,  C12N15/70 ,  C12P7/40 ,  C12P7/625 ,  C12P7/62

CPC分类号： C12P7/625 ,  C12N1/20 ,  C12N15/52 ,  C12N15/70 ,  C12P7/40 ,  C12P7/62 ,  C12Y106/05005 ,  C12Y401/01004 ,  C12Y401/02045 ,  C12Y402/0103 ,  C12Y402/01034 ,  C12N2800/101

摘要： Among other things, the present disclosure provides biosynthesis polypeptides, methods, and non-naturally occurring microbial organisms for preparing various compounds such as 1,5-pentanediol, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, and 2-keto carboxylic acids.