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    SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS
    5.
    发明申请
    SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS 有权
    选择性基质金属蛋白酶抑制剂

    公开(公告)号：US20170015647A1

    公开(公告)日：2017-01-19

    申请号：US15120508

    申请日：2015-02-20

    Applicant: University of Notre Dame du Lac

    Inventor： Mayland CHANG ,  Shahriar MOBASHERY

    IPC: C07D331/02

    CPC classification number: C07D331/02 ,  A61K9/0014 ,  A61K31/38 ,  A61K31/4245 ,  C07D303/34 ,  C07D413/12

    Abstract: The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

    Abstract translation: 本发明提供了用于治疗由基质金属蛋白酶（MMP）调节的疾病，病症或病症的化合物，组合物和方法。 该化合物可以是选择性MMP抑制剂，例如MMP-2，MMP-9和/或MMP-14的选择性抑制剂。 疾病，障碍或病症可包括例如中风，神经障碍，眼科疾病或伤口，例如慢性伤口或糖尿病性伤口。

    METHOD FOR STORING EPISULFIDE COMPOUND AND METHOD FOR PREPARING THIOEPOXY-BASED OPTICAL MATERIAL USING SAID EPISULFIDE COMPOUND
    7.
    发明申请
    METHOD FOR STORING EPISULFIDE COMPOUND AND METHOD FOR PREPARING THIOEPOXY-BASED OPTICAL MATERIAL USING SAID EPISULFIDE COMPOUND 有权
    储存EPISULFIDE化合物的方法和使用合适的EPISFF化合物制备基于硫代羟基的光学材料的方法

    公开(公告)号：US20150247955A1

    公开(公告)日：2015-09-03

    申请号：US14430802

    申请日：2013-09-24

    Applicant: KOC SOLUTION CO., LTD.

    Inventor： Dong Gyu Jang ,  Soo Gyun Roh ,  Jong Hyo Kim ,  Bong-Keun So ,  Jin-Moo Seo

    IPC: G02B1/04 ,  G02B1/08 ,  C07D331/02

    CPC classification number: G02B1/041 ,  C07D331/02 ,  C08G75/02 ,  C08L81/02 ,  G02B1/04 ,  G02B1/08 ,  C08L63/00 ,  C08L81/00

    Abstract: Disclosed is a method of storing a thioepoxy compound and a method of preparing a thioepoxy based optical material using the thioepoxy compound. Particularly, a method of preparing a high-quality thioepoxy based optical material having superior color and thermal stability and less time-dependent change, and being colorless and transparent by inhibiting time-dependent change of the thioepoxy compound during storage is disclosed. In addition, a method of storing the thioepoxy compound for an optical material, the thioepoxy compound having a water content of 500 to 2,500 ppm and stored at −78 to 10° C., and a method of preparing the thioepoxy based optical material, the method including polymerizing a polymerizable composition including the stored thioepoxy compound, are provided. The high-quality thioepoxy based optical material, which is colorless and transparent, prepared according to the present invention may be broadly used in a variety of fields as a substitute for conventional optical materials.

    Abstract translation: 公开了使用硫代环氧化合物存储硫代环氧化合物的方法和制备硫代环氧基光学材料的方法。 特别地，公开了一种制备具有优异的色素和热稳定性和较小的时间依赖性变化的高质量硫代环氧基光学材料的方法，并且通过抑制硫代环氧化合物在储存期间的时间依赖性变化而变得无色透明。 此外，存储用于光学材料的硫代环氧化合物的方法，水含量为500至2,500ppm并在-78至10℃下储存的硫代环氧化合物，以及制备硫代环氧基光学材料的方法， 提供包括使包含所存储的硫代环氧化合物的聚合性组合物聚合的方法。 根据本发明制备的无色透明的高质量硫代环氧基光学材料可广泛用于各种领域，作为常规光学材料的替代物。

    Multifunctional Materials And Composites
    8.
    发明申请
    Multifunctional Materials And Composites 有权
    多功能材料与复合材料

    公开(公告)号：US20140371443A1

    公开(公告)日：2014-12-18

    申请号：US14379021

    申请日：2013-02-15

    Applicant: Arizona Board of Regents, a Body Corporate of the State of Arizona Acting for and on behalf of ASU

    Inventor： Dong-Kyun Seo ,  Ki-Wan Jeon

    IPC: C07D331/02 ,  C08B15/00 ,  C08B11/20 ,  C07D345/00

    CPC classification number: C07D331/02 ,  B82Y30/00 ,  B82Y40/00 ,  C01B19/00 ,  C01B32/17 ,  C01B32/194 ,  C07D345/00 ,  C08B11/02 ,  C08B11/20 ,  C08B15/00 ,  C08B15/05 ,  C08L1/08 ,  C08L1/28 ,  C08L101/06 ,  Y02P20/134

    Abstract: Forming multifunctional materials and composites thereof includes contacting a first material having a plurality of oxygen-containing functional groups with a chalcogenide compound, and initiating a chemical reaction between the first material and the chalcogenide compound, thereby replacing oxygen in some of the oxygen-containing functional groups with chalcogen from the chalcogen-containing compound to yield a second material having chalcogen-containing functional groups and oxygen-containing functional groups. The first material is a carbonaceous material or a macromolecular material. A product including the second material is collected and may be processed further to yield a modified product or a composite.

    Abstract translation: 形成多功能材料及其复合材料包括使具有多个含氧官能团的第一材料与硫属化物化合物接触，并引发第一种材料和硫属化物化合物之间的化学反应，从而替代部分含氧官能团中的氧 具有来自含硫属化合物的硫属元素的基团，以产生具有含硫族官能团的官能团和含氧官能团的第二材料。 第一种材料是碳质材料或高分子材料。 收集包括第二材料的产品，并且可以进一步处理以产生改性产品或复合材料。

    Method for producing episulfide compound
    9.
    发明授权
    Method for producing episulfide compound 有权
    产生环硫化合物的方法

    公开(公告)号：US08586766B2

    公开(公告)日：2013-11-19

    申请号：US13577298

    申请日：2011-02-21

    Applicant: Mineki Kubo ,  Hiroshi Horikoshi

    Inventor： Mineki Kubo ,  Hiroshi Horikoshi

    IPC: C07D331/02 ,  C07D409/12 ,  C07D303/00

    CPC classification number: C07D331/02 ,  C08G75/08 ,  C08L81/02

    Abstract: A problem to be solved by the present invention is to provide an episulfide compound efficiently from an epoxy compound with no need of a measure against odor or corrosion, or a neutralization step. The present invention solved the above-described problem by a method for producing an episulfide compound in which an epoxy compound and a thiourea are reacted with each other in the presence of an ammonium compound.

    Abstract translation: 本发明要解决的问题是从环氧化合物中有效地提供环硫化合物，而不需要防止气味或腐蚀或中和步骤。 本发明通过其中环氧化合物和硫脲在铵化合物的存在下彼此反应的环硫化合物的制备方法解决了上述问题。

    Polymerization regulators and compositions for resin
    10.
    发明授权
    Polymerization regulators and compositions for resin 有权
    聚合调节剂和树脂组合物

    公开(公告)号：US07169845B2

    公开(公告)日：2007-01-30

    申请号：US10297383

    申请日：2002-04-04

    Applicant: Masaki Tamura ,  Takahiro Matsui ,  Masanori Shimuta ,  Yuichi Yoshimura ,  Motoharu Takeuchi ,  Hiroshi Horikoshi ,  Hiroyuki Okada

    Inventor： Masaki Tamura ,  Takahiro Matsui ,  Masanori Shimuta ,  Yuichi Yoshimura ,  Motoharu Takeuchi ,  Hiroshi Horikoshi ,  Hiroyuki Okada

    IPC: C08L81/00 ,  C08K3/16

    CPC classification number: C08G75/08 ,  C07D331/02

    Abstract: In the present invention, an episulfide compound having, in one molecule, at least one epithio structure represented by the following Formula 2: wherein R5 is C1–C10 hydrocarbylene or single bond, R6, R7 and R8 are each independently C1–C10 hydrocarbyl or hydrogen, Y is O, S, Se or Te, p is an integer from 1 to 5 and q is an integer from 0 to 5, is polymerized in the presence of a halide of a 13–16 group element of the long periodic table and/or a polymerization regulator represented by the following Formula 1: wherein R1, R2 and R3 are each C1–C10 hydocarbyl or hydrogen, R4 is C1–C10 hydrocarbylene or single bond, X is F, Cl, Br, I, As, SH, OH, C1–C10 alkoxyl, C1–C10 alkylthio, or C1–C10 mercaptoalkythio, and m is an integer from 1 to 5, to produce a cured resin suitable as an optical material. By using the polymerization regulator, the polymerization rate of the episulfide compound can be suitably regulated to obtain a cured resin with less defect. By using the halide, the increase in the viscosity of the starting composition during the storage or the casting operation can be prevented.

    Abstract translation: 在本发明中，在一个分子中具有由下式2表示的至少一个环硫结构的环硫化合物：其中R 5是C 1 -C 10亚烃基或单键，R 6 R 7和R 8各自独立地为C 1 -C 10烃基或氢，Y为O，S，Se或Te，p为1的整数 至5和q为0至5的整数，在长周期表的13-16族元素的卤化物和/或由下式1表示的聚合调节剂的存在下聚合：其中R“ 1，R 2和R 3各自为C 1 -C 10氢碳基或氢，R 4为C 1 -C 10亚烃基或单 键，X为F，Cl，Br，I，As，SH，OH，C 1 -C 10烷氧基，C 1 -C 10烷硫基或C 1 -C 10巯基偶氮，m为1〜5的整数， 作为光学材料。 通过使用聚合调节剂，可以适当调节环硫化合物的聚合速度，得到缺陷少的固化树脂。 通过使用卤化物，可以防止在储存或铸造操作期间起始组合物的粘度的增加。

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