公开(公告)号：US10005860B2

公开(公告)日：2018-06-26

申请号：US15428940

申请日：2017-02-09

Applicant: Basell Poliolefine Italia S.r.l.

Inventor： Alessandro Mignogna ,  Reynald Chevalier ,  Igor Kashulin ,  Ilya Nifant'ev ,  Giampiero Morini ,  Martin Schneider

IPC: C08F110/06 ,  C07C327/26 ,  C07C327/28 ,  C07C329/10 ,  C07C333/04

CPC classification number: C08F110/06 ,  C07C327/26 ,  C07C327/28 ,  C07C329/10 ,  C07C333/04 ,  C08F4/651 ,  C08F2500/12 ,  C08F2500/15 ,  C08F4/6545

Abstract: Catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of formula (I) In which X and Y are selected from, R1, and —OR1 and —NR2, B is oxygen or sulphur S is sulphur, R1 is selected from C1-C15 hydrocarbon groups, optionally contain a heteroatom selected from halogen, P, S, N, O and Si, which can be fused together to form one or more cycles, R is hydrogen or R1 and A is a bivalent bridging group with chain length between the two bridging bonds being 1-10 atoms.

公开(公告)号：US20130123486A1

公开(公告)日：2013-05-16

申请号：US13373513

申请日：2011-11-16

Applicant: Xiaolian GAO

Inventor： Xiaolian GAO

IPC: C07H21/00

CPC classification number: C07H21/00 ,  C07B2200/11 ,  C07C205/42 ,  C07C227/20 ,  C07C243/34 ,  C07C329/10 ,  C07C2603/18 ,  C07D257/04 ,  C07D295/205 ,  C07D317/52 ,  C07D317/62 ,  C07F9/2408 ,  C07F9/2429 ,  C07C229/36

Abstract: This invention describes reagent precursors and methods for chemical and biochemical reactions. These reagent precursors that can be activated in solution upon irradiation to generate reagents required for the subsequent chemical reactions. Specifically, photogenerated reagents (PGR) are useful for controlling parallel combinatorial synthesis and various chemical and biochemical reactions.

公开(公告)号：US20080255384A1

公开(公告)日：2008-10-16

申请号：US12098098

申请日：2008-04-04

Applicant: Rodolfo A. Martinez

Inventor： Rodolfo A. Martinez

IPC: C07C69/67 ,  C07C59/01 ,  C07C317/24 ,  C07C49/04

CPC classification number: C07C271/12 ,  B82Y10/00 ,  C07B59/00 ,  C07B2200/05 ,  C07C317/22 ,  C07C323/09 ,  C07C323/19 ,  C07C329/10 ,  C07D207/40 ,  G06N99/002

Abstract: Alkoxy[13C]methyl phenyl sulfone is a precursor to the production of Lithium (E)-β-Alkoxy[1,2,3-13C3]acrylate and thence Alkoxy (E)-β-Alkoxy[1,2,3-13C3]acrylate. Alkoxy (E)-β-Alkoxy[1,2,3-13C3]acrylate can then serve as a precursor for the production of a number of other isotopically labeled compounds. Similar chemistry using Alkoxy[14C]methyl phenyl sulfone as the precursor can yield 14C labeled compounds. High purity precursors ensure that the new compounds are also highly pure.

Abstract translation: 烷氧基[C 13 C]甲基苯基砜是制备（E） - 乙氧基锂（E）-β-烷氧基[12,3-13] 丙烯酸酯，然后是烷氧基（E） - β-烷氧基[1,2,3-三叔丁基]丙烯酸酯。 然后，烷氧基（E）-β-烷氧基[1,2,3-三叔丁基]丙烯酸酯可以用作制备许多其它同位素标记 化合物。 使用烷氧基[14 C]甲基苯基砜作为前体的相似化学方法可以产生14+标记的化合物。 高纯度前体确保新化合物也是高纯度的。

公开(公告)号：US20080027109A1

公开(公告)日：2008-01-31

申请号：US11833859

申请日：2007-08-03

Applicant: Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

Inventor： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

IPC: A61K31/435 ,  A61K31/164 ,  A61K31/18 ,  A61K31/341 ,  A61P9/00 ,  C07C233/00 ,  C07D207/00 ,  C07D221/00 ,  C07D333/02 ,  C07D307/02 ,  C07D213/00 ,  C07C311/00 ,  A61P9/10 ,  A61K31/44 ,  A61K31/381 ,  A61K31/40

CPC classification number: C07D307/10 ,  A61K31/164 ,  A61K31/18 ,  A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  C07C311/14 ,  C07C311/15 ,  C07C311/21 ,  C07C323/40 ,  C07C323/41 ,  C07C323/42 ,  C07C327/30 ,  C07C329/10 ,  C07C329/20 ,  C07C333/04 ,  C07C333/08 ,  C07C333/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/22 ,  C07C2602/28 ,  C07C2603/74 ,  C07D211/34 ,  C07D213/80 ,  C07D213/81 ,  C07D307/68 ,  C07D333/38 ,  Y02P20/55

Abstract: The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

Abstract translation: 本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 3， 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基; 低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，药学上可接受的盐或水合物或溶剂合物 其中。 由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

公开(公告)号：US20060122408A1

公开(公告)日：2006-06-08

申请号：US11242622

申请日：2005-10-03

Applicant: Xiaolian Gao ,  Jean Pellois ,  Wu Yao

Inventor： Xiaolian Gao ,  Jean Pellois ,  Wu Yao

IPC: C07D317/44 ,  C07C69/96 ,  G03C5/00

CPC classification number: C07H21/00 ,  C07B2200/11 ,  C07C205/42 ,  C07C227/20 ,  C07C243/34 ,  C07C329/10 ,  C07C2603/18 ,  C07D257/04 ,  C07D295/205 ,  C07D317/52 ,  C07D317/62 ,  C07F9/2408 ,  C07F9/2429 ,  C07C229/36

Abstract: This invention describes reagent precursors and methods for chemical and biochemical reactions. These reagent precursors that can be activated in solution upon irradiation to generate reagents required for the subsequent chemical reactions. Specifically, photogenerated reagents (PGR) are useful for controlling parallel combinatorial synthesis and various chemical and biochemical reactions.

公开(公告)号：US20030092708A1

公开(公告)日：2003-05-15

申请号：US10151813

申请日：2002-05-22

Applicant: Japan Tobacco, Inc., a Japan Corporation

Inventor： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

IPC: A61K031/54 ,  A61K031/537 ,  A61K031/495 ,  A61K031/445 ,  A61K031/277 ,  A61K031/40 ,  A61K031/165 ,  A61K031/18

CPC classification number: C07D307/10 ,  A61K31/164 ,  A61K31/18 ,  A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  C07C311/14 ,  C07C311/15 ,  C07C311/21 ,  C07C323/40 ,  C07C323/41 ,  C07C323/42 ,  C07C327/30 ,  C07C329/10 ,  C07C329/20 ,  C07C333/04 ,  C07C333/08 ,  C07C333/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/22 ,  C07C2602/28 ,  C07C2603/74 ,  C07D211/34 ,  C07D213/80 ,  C07D213/81 ,  C07D307/68 ,  C07D333/38 ,  Y02P20/55

Abstract: The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): 1 wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents nullCOnull or nullSO2null, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

Abstract translation: 本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基。 低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，其药学上可接受的盐或水合物或溶剂化物。 由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

公开(公告)号：US20230272130A1

公开(公告)日：2023-08-31

申请号：US18143562

申请日：2023-05-04

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： Dong-Chul Pyun ,  Robert A. Norwood ,  Roland Himmelhuber ,  Tristan Stephen Kleine ,  Liliana Ruiz Diaz ,  Laura E. Anderson

IPC: C08F112/14 ,  C07C329/10 ,  G02B1/04

CPC classification number: C08F112/30 ,  C07C329/10 ,  G02B1/04

Abstract: The present invention provides certain polymeric materials, precursors thereof as well as the preparation and uses thereof.

公开(公告)号：US08076372B2

公开(公告)日：2011-12-13

申请号：US12414321

申请日：2009-03-30

Applicant: John K. Inman ,  Atul Goel ,  Ettore Appella ,  Jim A. Turpin ,  Marco Schito

Inventor： John K. Inman ,  Atul Goel ,  Ettore Appella ,  Jim A. Turpin ,  Marco Schito

IPC: A61K31/21

CPC classification number: C07D213/20 ,  C07C323/62 ,  C07C329/10 ,  C07C329/20 ,  C07C333/08 ,  C07C333/24 ,  C07D213/06

Abstract: Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.

Abstract translation: 某些硫醇和酰基硫醇化合物通过攻击基本病毒蛋白的高度保守的锌指区域来抑制逆转录病毒的生长。 描述了这些化合物，含有它们的组合物和使用它们治疗逆转录病毒感染如HIV的方法。 这些化合物也可用于制备包括灭活的逆转录病毒如HIV的疫苗，预防这种逆转录病毒的传播，以及检测逆转录病毒蛋白质。

公开(公告)号：US07579379B2

公开(公告)日：2009-08-25

申请号：US11833859

申请日：2007-08-03

Applicant: Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

Inventor： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

IPC: A61K31/167 ,  C07C53/44 ,  C07C231/02 ,  C07C237/40 ,  C07C321/26

CPC classification number: C07D307/10 ,  A61K31/164 ,  A61K31/18 ,  A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  C07C311/14 ,  C07C311/15 ,  C07C311/21 ,  C07C323/40 ,  C07C323/41 ,  C07C323/42 ,  C07C327/30 ,  C07C329/10 ,  C07C329/20 ,  C07C333/04 ,  C07C333/08 ,  C07C333/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/22 ,  C07C2602/28 ,  C07C2603/74 ,  C07D211/34 ,  C07D213/80 ,  C07D213/81 ,  C07D307/68 ,  C07D333/38 ,  Y02P20/55

Abstract: The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

Abstract translation: 本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基。 低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，其药学上可接受的盐或水合物或溶剂化物。 由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

公开(公告)号：US20080009630A1

公开(公告)日：2008-01-10

申请号：US11648717

申请日：2006-12-29

Applicant: Xiaolian Gao ,  Zhou Xiaochuan ,  Wu Yao ,  Jean Pellois

Inventor： Xiaolian Gao ,  Zhou Xiaochuan ,  Wu Yao ,  Jean Pellois

IPC: C07D221/00 ,  C07C271/08 ,  C07C321/26 ,  C07C69/63 ,  C07D207/325

CPC classification number: C07H21/00 ,  C07B2200/11 ,  C07C205/42 ,  C07C227/20 ,  C07C243/34 ,  C07C329/10 ,  C07C2603/18 ,  C07D257/04 ,  C07D295/205 ,  C07D317/52 ,  C07D317/62 ,  C07F9/2408 ,  C07F9/2429 ,  C07C229/36

Abstract: This invention describes reagent precursors and methods for chemical and biochemical reactions. These reagent precursors that can be activated in solution upon irradiation to generate reagents required for the subsequent chemical reactions. Specifically, photogenerated reagents (PGR) are useful for controlling parallel combinatorial synthesis and various chemical and biochemical reactions.

Abstract translation: 本发明描述了用于化学和生化反应的试剂前体和方法。 这些试剂前体可以在照射时在溶液中活化，以产生后续化学反应所需的试剂。 具体来说，光生试剂（PGR）可用于控制平行组合合成和各种化学和生化反应。