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    NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES
    7.
    发明申请
    NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES 审中-公开
    新型合成抗氧化剂及其用途

    公开(公告)号：US20150336884A1

    公开(公告)日：2015-11-26

    申请号：US14647260

    申请日：2013-04-18

    申请人： Yansong Lu

    发明人： Yansong Lu

    IPC分类号： C07C327/06 ,  C07C327/26 ,  C07D487/04 ,  C07D213/65 ,  C07D241/24 ,  C07D239/38 ,  C07C327/48 ,  C07D213/83

    CPC分类号： C07C327/06 ,  C07C321/26 ,  C07C327/18 ,  C07C327/26 ,  C07C327/48 ,  C07D213/65 ,  C07D213/83 ,  C07D239/38 ,  C07D241/24 ,  C07D487/04

    摘要： The present invention relates to synthetic organic antioxidants of small molecules. The novel dithiol-containing compounds in this invention possess strongest possible capability as both scavenger for free radicals and antioxidant. This invention is directed to novel molecules as prodrugs of the novel dithiol-containing compounds, their rational design, their feasible preparation route by means of synthetic organic chemistry, and their potential uses in application to treatment and/or prevention of major diseases associated with oxidative stress, such as Alzheimer's disease, Parkinson's disease, cancer, diabetes, HIV, acne, cardiovascular disease, renal disease, hypertension, hypercholesterolemia, hyperlipidemia, rheumatoid arthritis, inflammation, pain, aging, stroke, cataract, glaucoma, age-related macular degeneration, etc.

    摘要翻译： 本发明涉及小分子的合成有机抗氧化剂。 本发明新型二硫醇化合物作为自由基和抗氧化剂的清除剂具有最强的可能性。 本发明涉及新型分子作为新二硫醇化合物的前药，其合理设计，其通过合成有机化学的可行制备途径及其在治疗和/或预防与氧化性相关的主要疾病中的潜在用途 压力，如阿尔茨海默病，帕金森病，癌症，糖尿病，艾滋病毒，痤疮，心血管疾病，肾脏疾病，高血压，高胆固醇血症，高脂血症，类风湿性关节炎，炎症，疼痛，老年，中风，白内障，青光眼，年龄相关性黄斑变性 等等

    Slightly water-soluble metal salts, a process for the preparation thereof, and the use thereof as gloss additives in the electrolytic deposition of metals
    8.
    发明授权
    Slightly water-soluble metal salts, a process for the preparation thereof, and the use thereof as gloss additives in the electrolytic deposition of metals 有权
    微溶于水的金属盐，其制备方法及其在金属的电解沉积中作为光泽添加剂的用途

    公开(公告)号：US5981793A

    公开(公告)日：1999-11-09

    申请号：US142857

    申请日：1998-10-28

    申请人： Eberhard Knaak ,  Joachim Heyer ,  Marlies Kleinfeld ,  Christel Van Wijngaarden

    发明人： Eberhard Knaak ,  Joachim Heyer ,  Marlies Kleinfeld ,  Christel Van Wijngaarden

    IPC分类号： C07C327/18 ,  C25D3/46 ,  C07C51/305

    CPC分类号： C25D3/46 ,  C07C327/18

    摘要： The slightly water-soluble metal salts having the formula I ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and represent hydrogen or a lower alkyl group of from 1 to 3 carbon atoms, M is the cation of a metal which forms slightly water-soluble sulfides, and n means 1 or 2, and mixtures thereof are prepared by reacting carbon disulfide with ketones having the formula II: ##STR2## optionally with the addition of non-aqueous inert solvents, in the presence of strong alkali, preferably potassium hydroxide, followed by precipitation of the slightly water-soluble metal salts of formula I by the addition of aqueous solutions of metal salts of the metals M. They are used as gloss additives to electrolytic baths.

    摘要翻译： PCT No.PCT / EP97 / 01389第 371日期：1998年9月16日 102（e）日期1998年9月16日PCT 1997年3月20日PCT公布。 第WO97 / 35840号公报 日期1997年10月2日具有式I的轻微水溶性金属盐，其中R 1和R 2相同或不同，表示氢或1至3个碳原子的低级烷基，M是形成金属的阳离子 微水溶性硫化物，n表示1或2，并且其混合物通过二硫化碳与具有式II的酮反应制备：任选地加入非水惰性溶剂，在强碱存在下，优选氢氧化钾 ，然后通过加入金属M的金属盐的水溶液沉淀出微溶于式I的水溶性金属盐。它们用作电解浴的光泽添加剂。