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公开(公告)号：US09814522B2
公开(公告)日：2017-11-14
申请号：US13081363
申请日：2011-04-06
申请人： Michael J. Drews , Bryan Wylie , Leslie Oley , Vahid Saadat
发明人： Michael J. Drews , Bryan Wylie , Leslie Oley , Vahid Saadat
CPC分类号： A61B18/1492 , A61B18/082 , A61B2018/00273 , A61B2018/00351 , A61B2018/00375 , A61B2018/0038 , A61B2018/00577 , A61B2018/00982 , A61B2018/1472 , A61B2018/1475 , A61B2090/0436 , A61B2090/0481 , A61B2218/002
摘要： Apparatus and methods for ablation efficacy are described herein where a hood having a deployable elongated feature can extend beyond a distal face of the hood. The elongated feature can channel the energy to the deeper regions within the tissue (such as trabeculated regions or other tissue structures) such that the energy can be delivered to the target tissue despite small or large irregularities in the target tissue surface (or region) and/or changes in the relative distances between the hood and the target tissue.
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2.发明申请VIRION DISPLAY ARRAY FOR PROFILING FUNCTIONS AND INTERACTIONS OF HUMAN MEMBRANE PROTEINS 审中-公开VIRION显示阵列用于人体膜蛋白的功能和相互作用公开(公告)号：US20160355789A1
公开(公告)日：2016-12-08
申请号：US14900314
申请日：2014-06-20
发明人： HENG ZHU , PRASHANT DESAI , MIN LI , SHAOHUI HU
IPC分类号： C12N7/00 , G01N33/74 , G01N33/566 , G01N33/68
CPC分类号： C12N7/00 , A61B17/3478 , A61B18/02 , A61B18/0218 , A61B2018/0038 , A61B2018/0212 , A61B2018/0275 , A61B2217/005 , C07K1/047 , C07K2319/03 , C07K2319/735 , C12N2710/16621 , C12N2710/16645 , C12N2810/855 , G01N33/566 , G01N33/6854 , G01N33/74 , G01N2333/70514 , G01N2333/726
摘要： Provided herein are recombinant virion arrays comprising human membrane bound proteins that retain their native conformations and/or interactions, recombinant HSV-1 virions, and methods of use including high-content, high-throughput assays for screening for ligands and/or drugs that bind human membrane bound proteins, diagnostic assays, proteomic assays, and bio-sensor assays. Also provided are recombinant HSV-1 virions comprising an envelope comprising a plurality of heterologous membrane bound proteins that retain their native conformations and/or interactions as well as recombinant HSV-1 bacterial artificial chromosome (BAC) clones encoding heterologous membrane polypeptides.
摘要翻译： 本文提供了包含保留其天然构象和/或相互作用的人膜结合蛋白的重组病毒粒子阵列，重组HSV-1病毒粒子，以及包括高含量，高通量测定法的筛选用于结合的配体和/或药物的高含量，高通量测定 人膜结合蛋白，诊断测定，蛋白质组学测定和生物传感器测定。 还提供了包含保持其天然构象和/或相互作用的多个异源膜结合蛋白以及编码异源膜多肽的重组HSV-1细菌人造染色体（BAC）克隆的包膜的重组HSV-1病毒粒子。
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公开(公告)号：US09498584B2
公开(公告)日：2016-11-22
申请号：US14060231
申请日：2013-10-22
CPC分类号： A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
摘要： An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member has a longitudinal framing member core defining a central framing member axis. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. The framing member comprises a plurality of longitudinally extending multi-segment framing strands.
摘要翻译： 用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。 框架构件具有限定中央框架构件轴线的纵向框架构件芯部。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 框架构件包括多个纵向延伸的多段框架线。
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公开(公告)号：US09358025B2
公开(公告)日：2016-06-07
申请号：US13843895
申请日：2013-03-15
发明人： Hiromu Sugiyama
IPC分类号： A61B17/28 , A61N7/02 , A61B18/14 , A61B17/00 , A61B17/50 , A61B18/00 , A61B18/18 , A61B18/20
CPC分类号： A61B17/2804 , A61B17/0057 , A61B17/50 , A61B18/1442 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B18/20 , A61B90/03 , A61B2017/00243 , A61B2017/00358 , A61B2017/0046 , A61B2017/00513 , A61B2017/00575 , A61B2017/00606 , A61B2017/00876 , A61B2018/0038 , A61B2018/00589 , A61B2018/00619 , A61B2018/0091 , A61B2090/037 , A61B2090/061 , A61N7/022
摘要： A medical device is configured to prevent a member attached to the distal end of an operation wire passing through a catheter from dropping out from an operation wire. The medical device includes an operation wire which passes through a catheter and which is advanceable and retractable toward the axial direction with respect to the catheter, a distal member interlocked on the distal side of the operation wire, and a grasping unit which is interlocked on the proximal side of the operation wire. The medical device also includes a safety mechanism for releasing the interlock between the operation wire and the grasping unit by a load lower than the breaking strength between the operation wire and the distal member.
摘要翻译： 医疗装置被配置为防止附着在通过导管的操作线的远端的部件从操作线掉出。 该医疗装置包括：通过导管的操作线，其能够相对于导管朝轴向前进和后退;远端部件，联接在操作线的远端侧;以及把持部， 操作线的近侧。 医疗装置还包括安全机构，用于通过低于操作线和远端构件之间的断裂强度的负载来释放操作线和把持单元之间的联锁。
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公开(公告)号：US20150265344A1
公开(公告)日：2015-09-24
申请号：US14731355
申请日：2015-06-04
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00196 , A61B2018/00351 , A61B2018/0038 , A61B2018/0212 , A61M2025/0089
摘要： A cardiac treatment system of the subject technology provides access across an interatrial septum of a patient. Such a treatment system can include a catheter having an ablation treatment device on an outer surface of a distal region thereof. A needle is provided at least partially within a lumen of the catheter. A control unit is operatively connected to the ablation treatment device for ablation of a portion of a septum by RF ablation. A distal end of a catheter is provided to the septum (e.g., at the fossa ovalis) of the patient while a distal tip of the needle is within the lumen and proximal to the distal end of the catheter. The distal tip of the needle punctures and crosses the septum, and a portion of the septum is ablated with an ablation treatment device aligned with the septum by guidance from the needle.
摘要翻译： 本科技术的心脏治疗系统提供穿过患者的房间隔的通路。 这种治疗系统可以包括在其远侧区域的外表面上具有消融治疗装置的导管。 针至少部分地设置在导管的内腔内。 控制单元可操作地连接到消融治疗装置，用于通过RF消融消融隔膜的一部分。 导管的远端提供给患者的隔膜（例如，在卵窝窝处），而针的远侧末端位于内腔内并且靠近导管的远端。 针的远端穿刺并穿过隔膜，并且通过来自针的引导与隔膜对准的消融治疗装置消融隔膜的一部分。
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公开(公告)号：US20180049804A1
公开(公告)日：2018-02-22
申请号：US15796325
申请日：2017-10-27
发明人： Michael J. Drews , Leslie Oley , Vahid Saadat , Bryan Wylie
CPC分类号： A61B18/1492 , A61B18/082 , A61B2018/00273 , A61B2018/00351 , A61B2018/00375 , A61B2018/0038 , A61B2018/00577 , A61B2018/00982 , A61B2018/1472 , A61B2018/1475 , A61B2090/0436 , A61B2090/0481 , A61B2218/002
摘要： Apparatus and methods for ablation efficacy are described herein where a hood having a deployable elongated feature can extend beyond a distal face of the hood. The elongated feature can channel the energy to the deeper regions within the tissue (such as trabeculated regions or other tissue structures) such that the energy can be delivered to the target tissue despite small or large irregularities in the target tissue surface (or region) and/or changes in the relative distances between the hood and the target tissue.
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公开(公告)号：US09445836B2
公开(公告)日：2016-09-20
申请号：US13944448
申请日：2013-07-17
发明人： Eugene M. Breznock
CPC分类号： A61B17/32053 , A61B17/00234 , A61B17/34 , A61B17/3415 , A61B17/3468 , A61B17/3478 , A61B2017/00247 , A61B2017/003 , A61B2017/00331 , A61B2017/320044 , A61B2018/00357 , A61B2018/0038 , A61B2018/00392
摘要： A transseptal punch with a steering mechanism within the punch, such that punch can be steered and deflected within a guide catheter during delivery, to avoid skiving of the guide catheter inner wall by passage of the punch tip through the guide catheter. The punch can be advanced through a body lumen in its straight configuration and then be selectively articulated or curved to permit negotiation of tortuous curvature or to permit optimal approach or access to a puncture site. The punch is able to create holes in the atrial septum of the heart or other structures and is easier to use than punches that are pre-curved near their distal tip since it is easier to advance through accessory catheters.
摘要翻译： 具有在冲头内的转向机构的经脉冲冲头，使得冲头可以在输送期间在引导导管内转向和偏转，以避免通过穿过引导导管穿过冲头尖端导向导管内壁。 打孔器可以通过其直的构型的体腔前进，然后被选择性地铰接或弯曲，以允许协商曲折曲折或允许最佳逼近或进入穿刺部位。 该冲头能够在心脏或其他结构的心房隔膜处产生孔，并且比其远侧末端附近预弯曲的冲头更容易使用，因为更容易通过辅助导管前进。
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公开(公告)号：US20150374933A9
公开(公告)日：2015-12-31
申请号：US14060274
申请日：2013-10-22
IPC分类号： A61M5/42
CPC分类号： A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
摘要： An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member, when deployed into an expanded condition, has a framing member body which includes a three-dimensionally bulbous portion defining a maximum body footprint in a lateral dimension and has longitudinally spaced proximal and distal body ends which are both longitudinally spaced from the maximum body footprint. The proximal body end is attached to the target catheter. A protrusion has a diameter which is smaller than the maximum body footprint diameter. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. At least one target pathway is attached to at least one target point. At least a portion of the target pathway is substantially spaced apart from the framing member body.
摘要翻译： 用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。 框架构件在展开状态时具有框架构件主体，该框架构件主体包括三维球形部分，其在侧向尺寸上限定最大身体足迹，并且具有纵向间隔开的近端和远侧主体端部， 身体足迹。 近端体端部附接到目标导管。 突起具有比最大身体足迹直径小的直径。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 至少一个目标通路连接至至少一个目标点。 目标通道的至少一部分与框架构件主体基本间隔开。
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公开(公告)号：US20140114246A1
公开(公告)日：2014-04-24
申请号：US14060274
申请日：2013-10-22
IPC分类号： A61M5/42
CPC分类号： A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
摘要： An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member, when deployed into an expanded condition, has a framing member body which includes a three-dimensionally bulbous portion defining a maximum body footprint in a lateral dimension and has longitudinally spaced proximal and distal body ends which are both longitudinally spaced from the maximum body footprint. The proximal body end is attached to the target catheter. A protrusion has a diameter which is smaller than the maximum body footprint diameter. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. At least one target pathway is attached to at least one target point. At least a portion of the target pathway is substantially spaced apart from the framing member body.
摘要翻译： 用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。 框架构件在展开状态时具有框架构件主体，该框架构件主体包括三维球形部分，其在侧向尺寸上限定最大身体足迹，并且具有纵向间隔开的近端和远侧主体端部， 身体足迹。 近端体端部附接到目标导管。 突起具有比最大身体足迹直径小的直径。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 至少一个目标通路连接至至少一个目标点。 目标通道的至少一部分与框架构件主体基本间隔开。
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公开(公告)号：US20140114244A1
公开(公告)日：2014-04-24
申请号：US14060231
申请日：2013-10-22
IPC分类号： A61M5/42
CPC分类号： A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
摘要： An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member has a longitudinal framing member core defining a central framing member axis. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. The framing member comprises a plurality of longitudinally extending multi-segment framing strands.
摘要翻译： 用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。 框架构件具有限定中央框架构件轴线的纵向框架构件芯部。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 框架构件包括多个纵向延伸的多段框架线。
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