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公开(公告)号：US20240148803A1
公开(公告)日：2024-05-09
申请号：US18546922
申请日：2022-02-18
发明人： Christopher B. FORD , Elizabethh HALVORSEN , Christopher DESJARDINS , Kankana BARDHAN , Swarma Deepa PANDIAN
IPC分类号： A61K35/742 , A61K35/745 , A61K45/06 , A61P35/04
CPC分类号： A61K35/742 , A61K35/745 , A61K45/06 , A61P35/04
摘要： Provided herein are methods and compositions for the treatment of various types of cancers by modulating the microbiome to effect or enhance the efficacy of immunotherapy. Also provided herein are methods of determining a response to an immunotherapy by identifying if a subject has a favorable microbial profile. Further provided herein are methods of determining a donor whose feces are useful for fecal matter transfer.
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公开(公告)号：US20240000859A1
公开(公告)日：2024-01-04
申请号：US18254449
申请日：2021-11-24
发明人： Matthew R. HENN , Edward J. O'BRIEN , Ambar PIÑA , Marin VULIC , Christopher B. FORD , Asuncion MARTINEZ , Divya BALASUBRAMANIAN , Elizabeth HALVORSEN , Karen KIESER , Mahmoud SALEH , Mary-Jane LOMBARDO , Sumon DATTA , Madhumitha NANDAKUMAR , Priyanka NARENDAR , Kankana BARDHAN
摘要： Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with a disease or disorder, such as those associated with immune suppression, including infections and/or GvHD, for example, in HSCT subjects. The bacterial compositions disclosed herein are designed to exhibit one or more functional features that are useful for the treatment of such diseases and disorders.
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公开(公告)号：US20230226126A1
公开(公告)日：2023-07-20
申请号：US17938184
申请日：2022-10-05
发明人： Matthew R. HENN , Geoffrey von MALTZAHN , Anthony Mario D'ONOFRIO , Kevin Daniel LITCOFSKY , David Arthur BERRY , David N. COOK , Noubar B. AFEYAN , John Grant AUNINS
IPC分类号： A61K35/742 , A61K35/74 , A23L33/10 , A23L33/135 , A61K38/13 , A23P10/30 , A61K9/00 , A61K9/48 , A61K45/06
CPC分类号： A61K35/742 , A61K35/74 , A23L33/127 , A23L33/135 , A61K38/13 , A23P10/30 , A61K9/0053 , A61K9/4891 , A61K45/06 , Y02A50/30 , A23V2002/00
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US11464812B2
公开(公告)日：2022-10-11
申请号：US17120671
申请日：2020-12-14
发明人： Matthew R. Henn , Geoffrey von Maltzahn , Anthony Mario D'Onofrio , Kevin Daniel Litcofsky , David Arthur Berry , David N. Cook , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/02 , A61K35/742 , A61K35/74 , A23L33/10 , A23L33/135 , A61K38/13 , A23P10/30 , A61K9/00 , A61K9/48 , A61K45/06
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US20210361721A1
公开(公告)日：2021-11-25
申请号：US15733682
申请日：2019-03-28
发明人： Jennifer WORTMAN , Diao LIYANG , Christopher DESJARDINS , Georgios MARNELLOS , Matthew HENN , Jennifer WARGO , Vancheswaran GOPALAKRISHNAN
IPC分类号： A61K35/741 , A61K35/742 , A61K35/745 , A61K39/395 , A61K31/675 , C12Q1/689 , C12Q1/04
摘要： Methods are provided for identifying donors of fecal matter that can improve a subject's response to a checkpoint inhibitor in the treatment of cancer. Methods and compositions are also provided for using donated fecal matter in the treatment of cancer.
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公开(公告)号：US20210169949A1
公开(公告)日：2021-06-10
申请号：US17120671
申请日：2020-12-14
发明人： Matthew R. HENN , Geoffrey von MALTZAHN , Anthony Mario D'ONOFRIO , Kevin Daniel LITCOFSKY , David Arthur BERRY , David N. COOK , Noubar B. AFEYAN , John Grant AUNINS
IPC分类号： A61K35/742 , A61K35/74 , A23L33/10 , A23L33/135 , A61K38/13 , A23P10/30 , A61K9/00 , A61K9/48 , A61K45/06
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US09446080B2
公开(公告)日：2016-09-20
申请号：US15068438
申请日：2016-03-11
发明人： Gregory McKenzie , Mary-Jane Lombardo McKenzie , David N. Cook , Marin Vulic , Geoffrey von Maltzahn , Brian Goodman , John Grant Aunins , Matthew R. Henn , David Arthur Berry , Jonathan Winkler
IPC分类号： A01N63/00 , A61K35/741 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K9/48 , C12N1/20
CPC分类号： A61K35/741 , A61K9/0053 , A61K9/48 , A61K9/4816 , A61K35/37 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , C12N1/20 , Y02A50/402 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481
摘要： Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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公开(公告)号：US12083151B2
公开(公告)日：2024-09-10
申请号：US17938184
申请日：2022-10-05
发明人： Matthew R. Henn , Geoffrey von Maltzahn , Anthony Mario D'Onofrio , Kevin Daniel Litcofsky , David Arthur Berry , David N. Cook , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/02 , A23L33/10 , A23L33/135 , A23P10/30 , A61K9/00 , A61K9/48 , A61K35/74 , A61K35/742 , A61K38/13 , A61K39/08 , A61K45/06
CPC分类号： A61K35/742 , A23L33/127 , A23L33/135 , A23P10/30 , A61K9/0053 , A61K9/4891 , A61K35/74 , A61K38/13 , A61K45/06 , A23V2002/00 , Y02A50/30
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US20240050490A1
公开(公告)日：2024-02-15
申请号：US18350081
申请日：2023-07-11
发明人： Gregory MCKENZIE , Mary-Jane LOMBARDO MCKENZIE , David N. COOK , Marin VULIC , Geoffrey VON MALTZAHN , Brian GOODMAN , John Grant AUNINS , Matthew R. HENN , David Arthur BERRY , Jonathan WINKLER
IPC分类号： A61K35/741 , A61K9/00 , A61K45/06 , A61K9/48 , C12N1/20 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K35/37
CPC分类号： A61K35/741 , A61K9/0053 , A61K45/06 , A61K9/48 , C12N1/20 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K9/4816 , A61K35/37 , Y02A50/30
摘要： Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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公开(公告)号：US11666612B2
公开(公告)日：2023-06-06
申请号：US17140385
申请日：2021-01-04
发明人： Matthew R. Henn , David N. Cook , Toshiro K. Ohsumi , Mary-Jane Lombardo McKenzie , Kevin D. Litcofsky , Han Zhang , John Grant Aunins , David Arthur Berry
IPC分类号： A61K35/742 , A61K35/74 , A61K35/741 , A61K35/745
CPC分类号： A61K35/742 , A61K35/74 , A61K35/741 , A61K35/745
摘要： Provided are therapeutic compositions containing combinations of bacteria, for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for use thereof.
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