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公开(公告)号：US11458174B2
公开(公告)日：2022-10-04
申请号：US17120666
申请日：2020-12-14
发明人： Matthew R. Henn , Geoffrey von Maltzahn , Anthony Mario D'Onofrio , Kevin Daniel Litcofsky , David Arthur Berry , David N. Cook , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/02 , A61K35/742 , A61K35/74 , A23L33/10 , A23L33/135 , A61K38/13 , A23P10/30 , A61K9/00 , A61K9/48 , A61K45/06
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US11464812B2
公开(公告)日：2022-10-11
申请号：US17120671
申请日：2020-12-14
发明人： Matthew R. Henn , Geoffrey von Maltzahn , Anthony Mario D'Onofrio , Kevin Daniel Litcofsky , David Arthur Berry , David N. Cook , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/02 , A61K35/742 , A61K35/74 , A23L33/10 , A23L33/135 , A61K38/13 , A23P10/30 , A61K9/00 , A61K9/48 , A61K45/06
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US20160158294A1
公开(公告)日：2016-06-09
申请号：US14765810
申请日：2014-02-04
发明人： Geoffrey Von Maltzahn , Matthew R. Henn , David N. Cook , David Arthur Berry , Noubar B. Afeyan , Brian Goodman , Mary-Jane Lombardo McKenzie , Marin Vulic
IPC分类号： A61K35/742 , A61K35/747 , A61K35/745 , A61K35/74 , A61K35/744
CPC分类号： A61K35/741 , A61K9/0053 , A61K9/48 , A61K9/4816 , A61K35/37 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , C12N1/20 , Y02A50/402 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481
摘要： Methods and compositions for populating the gastrointestinal tract of a subject are described. Methods include administering to a subject a therapeutic composition comprising a purified population of spore-forming bacteria produced by providing a fecal material and subjecting the material to a treatment step resulting in purification of spore forming bacteria. Methods include administering an amount effective to engraft and/or augment in the gastrointestinal tract in order to treat or prevent a dysbiosis in the mammalian subject.
摘要翻译： 描述了用于填充受试者的胃肠道的方法和组合物。 方法包括向受试者施用治疗组合物，所述治疗组合物包含通过提供粪便材料产生的纯化的孢子形成细菌群体，并使所述材料进行导致孢子形成细菌纯化的处理步骤。 方法包括给予在胃肠道中有效植入和/或增加的量以治疗或预防哺乳动物受试者中的生殖失调的量。
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公开(公告)号：US12083151B2
公开(公告)日：2024-09-10
申请号：US17938184
申请日：2022-10-05
发明人： Matthew R. Henn , Geoffrey von Maltzahn , Anthony Mario D'Onofrio , Kevin Daniel Litcofsky , David Arthur Berry , David N. Cook , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/02 , A23L33/10 , A23L33/135 , A23P10/30 , A61K9/00 , A61K9/48 , A61K35/74 , A61K35/742 , A61K38/13 , A61K39/08 , A61K45/06
CPC分类号： A61K35/742 , A23L33/127 , A23L33/135 , A23P10/30 , A61K9/0053 , A61K9/4891 , A61K35/74 , A61K38/13 , A61K45/06 , A23V2002/00 , Y02A50/30
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US11458173B2
公开(公告)日：2022-10-04
申请号：US17120657
申请日：2020-12-14
发明人： Matthew R. Henn , Geoffrey von Maltzahn , Anthony Mario D'Onofrio , Kevin Daniel Litcofsky , David Arthur Berry , David N. Cook , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/02 , A61K35/742 , A61K35/74 , A23L33/10 , A23L33/135 , A61K38/13 , A23P10/30 , A61K9/00 , A61K9/48 , A61K45/06
摘要： Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US11266699B2
公开(公告)日：2022-03-08
申请号：US16230807
申请日：2018-12-21
发明人： Matthew R. Henn , Kevin Daniel Litcofsky , Anthony Mario D'Onofrio , Toshiro K. Ohsumi , Mary-Jane Lombardo McKenzie , Geoffrey von Maltzahn , David N. Cook , David Arthur Berry , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K38/13 , A61K35/742 , A61K35/74 , C12N1/20 , A23L33/135 , A61K45/06 , A61K35/00
摘要： Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US20200345792A1
公开(公告)日：2020-11-05
申请号：US16230807
申请日：2018-12-21
发明人： Matthew R. Henn , Kevin Daniel Litcofsky , Anthony Mario D'Onofrio , Toshiro K. Ohsumi , Mary-Jane Lombardo McKenzie , Geoffrey von Maltzahn , David N. Cook , David Arthur Berry , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K35/742 , A61K35/74 , C12N1/20 , A23L33/135 , A61K45/06
摘要： Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US11918612B2
公开(公告)日：2024-03-05
申请号：US17588122
申请日：2022-01-28
发明人： Matthew R. Henn , Kevin Daniel Litcofsky , Anthony Mario D'Onofrio , Toshiro K. Ohsumi , Mary-Jane Lombardo McKenzie , Geoffrey Von Maltzahn , David N. Cook , David Arthur Berry , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/295 , A23L33/135 , A61K35/74 , A61K35/742 , A61K45/06 , C12N1/20 , A61K35/00
CPC分类号： A61K35/742 , A23L33/135 , A61K35/74 , A61K45/06 , C12N1/20 , A61K2035/11 , A61K2035/115 , Y02A50/30
摘要： Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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公开(公告)号：US20190192581A1
公开(公告)日：2019-06-27
申请号：US16051747
申请日：2018-08-01
发明人： Geoffrey von Maltzahn , Matthew R. Henn , David N. Cook , David Arthur Berry , Noubar B. Afeyan , Brian Goodman , Mary-Jane Lombardo McKenzie , Marin Vulic
IPC分类号： A61K35/741 , A61K45/06 , A61K35/742 , A61K9/48 , A61K35/747 , A61K35/745 , A61K35/744 , C12N1/20 , A61K35/74 , A61K9/00 , A61K35/37
CPC分类号： A61K35/741 , A61K9/0053 , A61K9/48 , A61K9/4816 , A61K35/37 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , C12N1/20 , Y02A50/402 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481 , Y02A50/49
摘要： Methods and compositions for populating the gastrointestinal tract of a subject are described. Methods include administering to a subject a therapeutic composition comprising a purified population of spore-forming bacteria produced by providing a fecal material and subjecting the material to a treatment step resulting in purification of spore-form ing bacteria. Methods include administering an amount effective to engraft and/or augment in the gastrointestinal tract in order to treat or prevent a dysbiosis in the mammalian subject.
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公开(公告)号：US10258655B2
公开(公告)日：2019-04-16
申请号：US15039007
申请日：2014-11-25
发明人： Matthew R. Henn , Kevin Daniel Litcofsky , Anthony Mario D'Onofrio , Toshiro K. Ohsumi , Mary-Jane Lombardo McKenzie , Geoffrey von Maltzahn , David N. Cook , David Arthur Berry , Noubar B. Afeyan , John Grant Aunins
IPC分类号： A61K39/02 , A61K35/742 , A61K35/74 , C12N1/20 , A23L33/135 , A61K45/06 , A61K35/00
摘要： Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
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