公开(公告)号：US20240148803A1

公开(公告)日：2024-05-09

申请号：US18546922

申请日：2022-02-18

申请人： Seres Therapeutics, Inc.

发明人： Christopher B. FORD ,  Elizabethh HALVORSEN ,  Christopher DESJARDINS ,  Kankana BARDHAN ,  Swarma Deepa PANDIAN

IPC分类号： A61K35/742 ,  A61K35/745 ,  A61K45/06 ,  A61P35/04

CPC分类号： A61K35/742 ,  A61K35/745 ,  A61K45/06 ,  A61P35/04

摘要： Provided herein are methods and compositions for the treatment of various types of cancers by modulating the microbiome to effect or enhance the efficacy of immunotherapy. Also provided herein are methods of determining a response to an immunotherapy by identifying if a subject has a favorable microbial profile. Further provided herein are methods of determining a donor whose feces are useful for fecal matter transfer.

公开(公告)号：US20210361721A1

公开(公告)日：2021-11-25

申请号：US15733682

申请日：2019-03-28

申请人： SERES THERAPEUTICS, INC. ,  Board of Regents, The University of Texas System

发明人： Jennifer WORTMAN ,  Diao LIYANG ,  Christopher DESJARDINS ,  Georgios MARNELLOS ,  Matthew HENN ,  Jennifer WARGO ,  Vancheswaran GOPALAKRISHNAN

IPC分类号： A61K35/741 ,  A61K35/742 ,  A61K35/745 ,  A61K39/395 ,  A61K31/675 ,  C12Q1/689 ,  C12Q1/04

摘要： Methods are provided for identifying donors of fecal matter that can improve a subject's response to a checkpoint inhibitor in the treatment of cancer. Methods and compositions are also provided for using donated fecal matter in the treatment of cancer.