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公开(公告)号：US10345264B2
公开(公告)日：2019-07-09
申请号：US15569822
申请日：2016-04-28
发明人： Jan Hendrikse , Vladimir Romanov , Udo Verkerk , Alan Hopkinson
摘要： The present disclosure relates to an ion exchange process, as well as a process and system for detecting nitrates, which employ a class of dopants comprising at least two functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion. In an aspect, the present disclosure provides an ion exchange process for forming a negatively charged nitrate-dopant ion analyte for analysis by a spectrometry analysis instrument, comprising: providing a gas comprising a dopant in both neutral and ionized forms; contacting a nitrate-containing sample with the gas comprising the dopant and thereby desorbing a nitrate ion from the sample to form a negatively charged nitrate-dopant ion analyte and replacing the desorbed nitrate ion with a negatively charged ionized dopant molecule; wherein the dopant is an organic compound comprising two or more carbon atoms and two or more functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion; or the dopant is an organic compound comprising at least two carbon atoms and only a single functional group capable of hydrogen bonding with a nitrate ion, which group is a —COOH functional group, and where the carbon atom of the —COOH functional group is bonded directly to another carbonyl group; and with the proviso that the dopant is not lactic acid, a lactic acid salt or a compound that forms lactate ions upon ionization.
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2.发明申请公开(公告)号：US20180275018A1
公开(公告)日：2018-09-27
申请号：US15989502
申请日：2018-05-25
摘要： An ion mobility spectrometer analytical instrument, including an ion mobility spectrometer, a swab interface, and a desorber assembly. The desorber assembly includes a heat transfer device configured to heat a desorber, as well as a supply configured to direct gas through the desorber. The instrument further includes a drift tube, high voltage device arrayed, at least in part, proximate to the drift tube, wherein the high voltage device is configured to change a polarity of a voltage applied to the drift tube and have an absolute voltage of about 500 to 1500 volts. The instrument further includes a reactant supply unit adapted to supply reactant during a sample substance analysis, and a control unit.
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公开(公告)号：US20130297227A1
公开(公告)日：2013-11-07
申请号：US13881823
申请日：2011-10-27
申请人： Julian C. Burton , Reno F. DeBono
发明人： Julian C. Burton , Reno F. DeBono
IPC分类号： G01N23/00
CPC分类号： G01N27/622 , B08B6/00 , G01N23/00 , G06K9/0053 , H01J49/0031 , H01J49/025 , H01J49/04 , H01J49/06 , H01J49/061
摘要： Method and systems for monitoring ion mobility spectrometers are provided. The method can include acquiring scan data, and generating a segment data set from the scan data. The method can further include deriving a subset of peak data from the segment data, where the subset of peak data has an associated set of peak metrics, and deriving a value from the subset of peak data associated with a criteria element of the associated set of peak metrics, where the criteria element has an associated range of values. The method can further include providing an indication in the event the value lies outside the associated range of values.
摘要翻译： 提供了用于监测离子迁移率光谱仪的方法和系统。 该方法可以包括获取扫描数据，以及从扫描数据生成段数据集。 所述方法还可以包括从所述段数据导出峰值数据的子集，其中所述峰值数据的子集具有相关联的峰值度量集合，以及从与所述相关联的组的标准元素相关联的峰值数据的子集中导出值 峰值度量，其中标准元素具有相关联的值范围。 该方法还可以包括在值处于相关值范围之外的情况下提供指示。
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公开(公告)号：US20210389275A1
公开(公告)日：2021-12-16
申请号：US17412997
申请日：2021-08-26
发明人： Qunzhou Bian , John J. Carroll
IPC分类号： G01N27/622 , H01J49/00 , B08B6/00 , G06K9/00 , H01J49/02 , H01J49/06 , G01N23/00 , H01J49/04
摘要： Method and systems for managing clear-down are provided. The method can include generating a clear-down trigger associated with an ion mobility spectrometer and operating the ion mobility spectrometer in fast clear-down mode in response to the clear-down trigger. Methods and systems can further provide that where the ion mobility spectrometer operates in fast-switching mode, the ion mobility spectrometer alternating a plurality of times between operation according to a positive ion mode and operation according to a negative ion mode, and further operating according to the positive ion mode for less than about 1 second before switching to the operation according to the negative ion mode, and operating according to the negative ion mode for less than about 1 second before switching to the operation according to the positive ion mode.
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公开(公告)号：US10139366B2
公开(公告)日：2018-11-27
申请号：US14218109
申请日：2014-03-18
发明人： Bohdan Atamanchuk , Volodimir Bondarenko , Vlad Sergeyev , Henryk Zaleski , Daniel Levin , Mark Piniarski , Igor Kubelik , Qunzhou Bian , Simon Feldberg , Douglas J. Green , Brian Boso , Atin J. Patel
摘要： An ion detection assembly is described that includes a drift chamber, an inlet assembly, and a collector assembly. The drift chamber is formed of substantially non-conductive material and/or semi-conductive material. A patterned resistive trace is deposited on one or more of an interior surface or an exterior surface of the drift chamber. The patterned resistive trace is configured to connect to a source of electrical energy. The inlet assembly and the collector assembly are in fluid communication with the drift chamber. The inlet assembly includes an inlet for receiving a sample, a reaction region for ionizing the sample, and a gate for controlling entrance of the ionized sample to the drift chamber. The collector assembly includes a collector plate for collecting the ionized sample after the ionized sample passes through the drift chamber.
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公开(公告)号：US09287102B2
公开(公告)日：2016-03-15
申请号：US13881821
申请日：2011-10-27
申请人： Henryk Zaleski , Mark Piniarski , Simon Feldberg , Jeff Anderson , Oleg Samarin
发明人： Henryk Zaleski , Mark Piniarski , Simon Feldberg , Jeff Anderson , Oleg Samarin
CPC分类号： G01N27/622 , G01N23/00 , G06K9/0053 , H01J49/0031 , H01J49/025 , H01J49/04 , H01J49/06 , H01J49/061
摘要： Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.
摘要翻译： 所公开的系统和方法提供了在离子迁移谱仪中管理极性切换的方法，并且在极性切换期间提供排斥电网电压，门控电网电压和固定电网电压的管理。 系统和方法还提供了在靠近集电极的绝缘体中对介电弛豫的影响的管理，并且提供耦合到集电器的前置放大器，包括开关，以及管理包括开关的集电极输出的方法。 与本公开一致的系统和方法进一步提供了通过确定与多个测量数据集相关联的拟合系数来归一化离子迁移率数据的方法，以及从由离子迁移谱仪获取的数据中减去由拟合系数确定的曲线。
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公开(公告)号：US09134208B2
公开(公告)日：2015-09-15
申请号：US13562762
申请日：2012-07-31
申请人： Jan Hendrikse , Vladimir Romanov
发明人： Jan Hendrikse , Vladimir Romanov
CPC分类号： G01N1/44 , G01N2001/002 , H01J49/049
摘要： A sample introduction system configured for introducing analytes of a solid phase micro extraction (SPME) sample into an analytical instrument system (e.g., mass spectrometer) is described. The sample introduction system includes a pressure vessel configured with an inlet port via which a probe portion (e.g., SPME fiber) of a SPME assembly is received into a sealed volume of the pressure vessel. The probe portion of the SPME assembly is coated with an extracting phase material, the analytes being absorbed into and/or adsorbed onto the extracting phase material. The pressure vessel is configured for providing an environment in which desorption of the analytes from the extracting phase material occurs at a gaseous pressure which is substantially less than atmospheric pressure (e.g., less than 100 mTorr). The desorbed analytes are then directed to the vacuum chamber of the analytical instrument system via an outlet port of the pressure vessel.
摘要翻译： 描述了配置用于将固相微萃取（SPME）样品的分析物引入分析仪器系统（例如质谱仪）中的样品引入系统。 样品引入系统包括配置有入口的压力容器，SPME组件的探针部分（例如，SPME纤维）经由该入口接收到压力容器的密封体积中。 SPME组件的探针部分涂覆有萃取相材料，分析物被吸收到和/或吸附到萃取相材料上。 压力容器被配置为提供一种环境，其中分析物从萃取相材料中的解吸附在基本上小于大气压（例如小于100mTorr）的气体压力下发生。 解吸的分析物然后通过压力容器的出口导入分析仪器系统的真空室。
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8.发明授权公开(公告)号：US09048077B2
公开(公告)日：2015-06-02
申请号：US14362555
申请日：2012-12-05
发明人： Jan Hendrikse
CPC分类号： H01J49/04 , G01N27/624 , H01J49/0031 , H01J49/0036 , H01J49/0081
摘要： A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer. A processing system compares results of the pre-mass spectrometry screening to an analyte database, wherein correlation of the results to an analyte within the analyte database comprises a preliminary positive identification. When the processing system determines that a preliminary positive identification is made, it causes the gate to open for a period of time. However, when the processing system determines that a preliminary positive identification is not made, it causes the gate to remain closed.
摘要翻译： 用于筛选一种或多种分析物的样品的质谱系统包括预质谱筛选装置，其被配置为预先筛选电离样品以产生与样品的组成相关的输出和质谱仪。 打开样品门以允许至少一部分离子化样品流到质谱仪并关闭以防止离子化样品流向质谱仪。 处理系统将预质谱筛选的结果与分析物数据库进行比较，其中结果与分析物数据库内的分析物的相关性包括初步阳性鉴定。 当处理系统确定进行初步的肯定识别时，会使门打开一段时间。 然而，当处理系统确定没有进行初步肯定识别时，它使门保持关闭。
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9.发明申请公开(公告)号：US20140339417A1
公开(公告)日：2014-11-20
申请号：US14362555
申请日：2012-12-05
发明人： Jan Hendrikse
CPC分类号： H01J49/04 , G01N27/624 , H01J49/0031 , H01J49/0036 , H01J49/0081
摘要： A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer. A processing system compares results of the pre-mass spectrometry screening to an analyte database, wherein correlation of the results to an analyte within the analyte database comprises a preliminary positive identification. When the processing system determines that a preliminary positive identification is made, it causes the gate to open for a period of time. However, when the processing system determines that a preliminary positive identification is not made, it causes the gate to remain closed.
摘要翻译： 用于筛选一种或多种分析物的样品的质谱系统包括预质谱筛选装置，其被配置为预先筛选电离样品以产生与样品的组成相关的输出和质谱仪。 打开样品门以允许至少一部分离子化样品流到质谱仪并关闭以防止离子化样品流向质谱仪。 处理系统将预质谱筛选的结果与分析物数据库进行比较，其中结果与分析物数据库内的分析物的相关性包括初步阳性鉴定。 当处理系统确定进行初步的肯定识别时，会使门打开一段时间。 然而，当处理系统确定没有进行初步肯定识别时，它使门保持关闭。
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公开(公告)号：US20110240838A1
公开(公告)日：2011-10-06
申请号：US13124213
申请日：2009-10-26
CPC分类号： G01N33/0013 , G01N27/622
摘要： An ion mobility spectrometer includes a permeation tube, ammonium sulfate disposed within the permeation tube in solid form, and a heating device configured to heat the permeation tube so as to create ammonia gas to flow within the permeation tube. When an array of sensors of the IMS is placed in contact with an unknown sample, the ammonia operates as a reactant so as to provide detection signals that are provided to a processor unit of the IMS, so as to identify the unknown sample based on its ion mobility spectrum.
摘要翻译： 离子迁移谱仪包括以固体形式设置在渗透管内的渗透管，硫酸铵，以及加热装置，其构造为加热渗透管，以产生氨气在渗透管内流动。 当IMS的传感器阵列与未知样品接触时，氨作为反应物运行，以便提供提供给IMS的处理器单元的检测信号，以便基于其识别未知样品 离子迁移谱。
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