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1.发明授权Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia 有权将患者的治疗方案从静脉内施用阿片样物质转化成口服给予吗啡和羟考酮的方法，使用计量算法提供镇痛公开(公告)号：US07923453B1
公开(公告)日：2011-04-12
申请号：US12881677
申请日：2010-09-14
IPC分类号： A01N43/42 , A01N43/38 , A01N37/10 , A61K31/44 , A61K31/40 , A61K31/19 , A61K9/28 , A61K9/20 , C07D489/00
CPC分类号： C07D489/08 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
摘要翻译： 将包括静脉内施用阿片样物质的疼痛治疗转化为疼痛治疗的方法，包括在需要镇痛的患者中口服施用第一剂量的立即释放吗啡 - 羟考酮组合。 该方法可以包括（1）确定四小时平均口服吗啡等价物或确定净平均小时静脉内剂量，和（2）以3：2的比例口服给予患者第一剂量的吗啡 - 羟考酮组合 每四至六小时一次。 另外，一种治疗已被静脉内施用阿片样物质的患者的疼痛的方法，包括使用给药算法来确定即时释放吗啡 - 羟考酮组合的第一剂量。
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公开(公告)号：US20140183070A1
公开(公告)日：2014-07-03
申请号：US13958368
申请日：2013-08-02
申请人： QRxPharma Ltd.
发明人： John W. Holaday , Edward M. Rudnic , Beth A. Burnside , Donald Treacy , Marcus Schestopol , Kristin Benokraitis , Ed Browka , Jessie Delgado , David Foshee
IPC分类号： B09B3/00
CPC分类号： B09B3/0075
摘要： A device for the neutralization and disposal of unused medicaments, such as drugs or medications. The device generally comprises a means of storing disposal device material, which can render medicaments unusable, and a means of exposing the disposal device material to the medicaments when they are no longer in use. The device may be a medicament container comprising a reservoir to store the disposal device material, and a means to expose the disposal device material to the medicaments. Alternatively, the device may be a medicament closure or lid for use with a medicament container, in which the closure comprises a reservoir for storing the disposal device material and a means to expose the disposal device material to the medicaments.
摘要翻译： 用于中和和处置未使用药物如药物或药物的装置。 该装置通常包括存储处置装置材料的装置，其可以使药物不可用，以及当处理装置材料不再使用时将该处置装置材料暴露于药物的手段。 该装置可以是包括用于存储处置装置材料的储存器的药物容器，以及将处置装置材料暴露于药物的手段。 或者，该装置可以是与药物容器一起使用的药物封闭物或盖子，其中封闭物包括用于储存处置装置材料的储存器和用于将处置装置材料暴露于药物的装置。
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公开(公告)号：US20140187842A1
公开(公告)日：2014-07-03
申请号：US14142736
申请日：2013-12-27
申请人： QRxPharma Ltd.
发明人： John W. Holaday , Edward M. Rudnic , Beth A. Burnside , Marcus Schestopol , Donald Treacy , Michael Vachon , Sean Higgins , Gary W. Pace
IPC分类号： B09B3/00
CPC分类号： B09B3/0075
摘要： Device for the neutralization and disposal of unused human or animal pharmaceutical medicament. The device comprises a disposal device material that contains one or more disposal device agents. The disposal device material may also contain additional components to promote mixing, or neutralization of the active agent of the medicament. The disposal device material can be in the form of pellets, beads, beadlets, granules, or the like, and can be incorporated into a disposal device reservoir. The disposal device can be dispensed with a medicament, and the device can be used when the patient has finished using the medicament and there is material left over for disposal.
摘要翻译： 用于中和和处置未使用的人或动物药物的装置。 该装置包括含有一种或多种处置装置剂的处置装置材料。 处理装置材料还可以含有另外的组分以促进药物的活性剂的混合或中和。 处置装置材料可以是丸粒，珠粒，珠粒，颗粒等的形式，并且可以并入到处理装置储存器中。 处置装置可以被分配药物，并且当患者完成使用药物并且留有剩余的材料以便处理时可以使用该装置。
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4.发明授权Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia 失效将患者的治疗方案从静脉内施用阿片样物质转化成口服给予吗啡和羟考酮的方法，使用计量算法提供镇痛公开(公告)号：US08222267B2
公开(公告)日：2012-07-17
申请号：US13185016
申请日：2011-07-18
IPC分类号： A01N43/42 , A01N43/38 , A01N37/10 , A61K31/44 , A61K31/40 , A61K31/19 , A61K9/28 , A61K9/20 , C07D489/00
CPC分类号： A61K31/485 , A61K2300/00
摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents, a one-hour average oral morphine equivalents, or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
摘要翻译： 将包括静脉内施用阿片样物质的疼痛治疗转化为疼痛治疗的方法，包括在需要镇痛的患者中口服施用第一剂量的立即释放吗啡 - 羟考酮组合。 该方法可以包括（1）确定四小时的平均口服吗啡当量，1小时的平均口服吗啡等同物或确定净平均每小时静脉内剂量，和（2）口服给予患者第一剂量的吗啡 - 氧可酮组合，每4至6小时，重量比为3：2。 另外，一种治疗已被静脉内施用阿片样物质的患者的疼痛的方法，包括使用给药算法来确定即时释放吗啡 - 羟考酮组合的第一剂量。
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公开(公告)号：US08461171B2
公开(公告)日：2013-06-11
申请号：US13024298
申请日：2011-02-09
申请人： John W. Holaday , Philip Magistro
发明人： John W. Holaday , Philip Magistro
IPC分类号： A61K31/485
CPC分类号： A61K47/481 , A61K31/485 , A61K47/55 , A61K2300/00
摘要： Disclosed are hybrid opioid compounds, mixed opioid salts, compositions comprising the hybrid opioid compounds and mixed opioid salts, and methods of use thereof. More particularly, in one aspect the hybrid opioid compound includes at least two opioid compounds that are covalently bonded to a linker moiety. In another aspect, the hybrid opioid compound relates to mixed opioid salts comprising at least two different opioid compounds or an opioid compound and a different active agent. Also disclosed are pharmaceutical compositions, as well as to methods of treating pain in humans using the hybrid compounds and mixed opioid salts.
摘要翻译： 公开了混合阿片类化合物，混合阿片样物质盐，包含混合阿片样物质和混合阿片样物质的组合物及其使用方法。 更具体地，在一个方面，混合阿片样物质化合物包括共价键合到接头部分的至少两种阿片样化合物。 另一方面，混合阿片类化合物涉及包含至少两种不同的阿片样化合物或阿片样物质和不同活性剂的混合阿片样物质盐。 还公开了药物组合物，以及使用混合化合物和混合阿片样物质治疗人类疼痛的方法。
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公开(公告)号：US08012990B2
公开(公告)日：2011-09-06
申请号：US12881728
申请日：2010-09-14
IPC分类号： A01N43/42 , A01N43/38 , A01N37/10 , A61K31/44 , A61K31/40 , A61K9/28 , A61K9/20 , C07D489/00 , A61K31/19
CPC分类号： A61K31/485 , A61K2300/00
摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
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