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    METHODS FOR DETECTING ENHANCED RISK OF OPIOID-INDUCED HYPOXIA IN A PATIENT
    1.
    发明申请
    METHODS FOR DETECTING ENHANCED RISK OF OPIOID-INDUCED HYPOXIA IN A PATIENT 审中-公开
    检测患者中阿片样物质诱导性高血压风险增加的方法

    公开(公告)号：US20120283283A1

    公开(公告)日：2012-11-08

    申请号：US13464025

    申请日：2012-05-04

    申请人： Warren C. Stern ,  Patricia T. Richards

    发明人： Warren C. Stern ,  Patricia T. Richards

    IPC分类号： G01N33/50 ,  A61P25/00 ,  A61K31/485

    CPC分类号： A61B5/4848 ,  A61B5/08 ,  A61K31/485 ,  A61K2300/00

    摘要： Methods for detecting enhanced risk of opioid-induced respiratory dysfunction in patients with normal levels of oxygen saturation. The method may comprise: (1) assaying blood of the patient for a normal level of oxygen saturation; (2) measuring the patient's respiration rate at rest for a normal rate; and (3) correlating the normal level of oxygen saturation and the normal rate of respiration with enhanced risk of opioid-induced respiratory dysfunction if: (a) the patient is at an altitude of about 1000 feet above sea level or greater; or (b) the patient's oxygen saturation level is normal but no greater than about 95%; or (c) the patient received prior dosing with intravenous opioid and is converted to dosing with an oral opioid. The method may further comprise administering opioids to a patient after detecting whether there is an enhanced risk of opioid-induced respiratory dysfunction.

    摘要翻译： 检测氧饱和度正常水平患者阿片样物质诱导的呼吸功能障碍风险增加的方法。 该方法可以包括：（1）测定患者的血液的正常氧饱和度水平; （2）以正常率测定患者的休息呼吸频率; 和（3）如果：（a）患者处于海拔1000英尺或更高的海拔高度，则将正常氧饱和度水平与正常呼吸速率相关联，增加阿片样物质诱导的呼吸功能障碍的风险; 或（b）患者的氧饱和度水平正常但不大于约95％; 或（c）患者接受静脉注射阿片样物质，并转为口服阿片样物质给药。 该方法还可以包括在检测阿片样物质诱导的呼吸功能障碍的风险是否增加之后向患者施用阿片样物质。

    Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia
    5.
    发明申请
    Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia 失效
    将患者的治疗方案从静脉内施用阿片样物质转变成口服给药吗啡和羟考酮的方法，使用剂量算法提供镇痛

    公开(公告)号：US20120041014A1

    公开(公告)日：2012-02-16

    申请号：US13185016

    申请日：2011-07-18

    申请人： Patricia T. RICHARDS ,  Warren C. Stern ,  Laurel J. Mengle-Gaw ,  Benjamin Schwartz

    发明人： Patricia T. RICHARDS ,  Warren C. Stern ,  Laurel J. Mengle-Gaw ,  Benjamin Schwartz

    IPC分类号： A61K31/485 ,  A61P25/04

    CPC分类号： A61K31/485 ,  A61K2300/00

    摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents, a one-hour average oral morphine equivalents, or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.

    摘要翻译： 将包括静脉内施用阿片样物质的疼痛治疗转化为疼痛治疗的方法，包括在需要镇痛的患者中口服施用第一剂量的立即释放吗啡 - 羟考酮组合。 该方法可以包括（1）确定四小时的平均口服吗啡当量，1小时的平均口服吗啡等同物或确定净平均每小时静脉内剂量，和（2）口服给予患者第一剂量的吗啡 - 氧可酮组合，每4至6小时，重量比为3：2。 另外，一种治疗已被静脉内施用阿片样物质的患者的疼痛的方法，包括使用给药算法来确定即时释放吗啡 - 羟考酮组合的第一剂量。

    Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia
    7.
    发明申请
    Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia 有权
    将患者的治疗方案从静脉内施用阿片样物质转变成口服给药吗啡和羟考酮的方法，使用剂量算法提供镇痛

    公开(公告)号：US20110086873A1

    公开(公告)日：2011-04-14

    申请号：US12881677

    申请日：2010-09-14

    申请人： Patricia T. Richards ,  Warren C. Stern ,  Laurel J. Mengle-Gaw ,  Benjamin D. Schwartz

    发明人： Patricia T. Richards ,  Warren C. Stern ,  Laurel J. Mengle-Gaw ,  Benjamin D. Schwartz

    IPC分类号： A61K31/485 ,  A61P25/04

    CPC分类号： C07D489/08 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

    摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.

    摘要翻译： 将包括静脉内施用阿片样物质的疼痛治疗转化为疼痛治疗的方法，包括在需要镇痛的患者中口服施用第一剂量的立即释放吗啡 - 羟考酮组合。 该方法可以包括（1）确定四小时平均口服吗啡等价物或确定净平均小时静脉内剂量，和（2）以3：2的比例口服给予患者第一剂量的吗啡 - 羟考酮组合 每四至六小时一次。 另外，一种治疗已被静脉内施用阿片样物质的患者的疼痛的方法，包括使用给药算法来确定即时释放吗啡 - 羟考酮组合的第一剂量。