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1.发明授权Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia 有权将患者的治疗方案从静脉内施用阿片样物质转化成口服给予吗啡和羟考酮的方法，使用计量算法提供镇痛公开(公告)号：US07923453B1
公开(公告)日：2011-04-12
申请号：US12881677
申请日：2010-09-14
IPC分类号： A01N43/42 , A01N43/38 , A01N37/10 , A61K31/44 , A61K31/40 , A61K31/19 , A61K9/28 , A61K9/20 , C07D489/00
CPC分类号： C07D489/08 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
摘要翻译： 将包括静脉内施用阿片样物质的疼痛治疗转化为疼痛治疗的方法，包括在需要镇痛的患者中口服施用第一剂量的立即释放吗啡 - 羟考酮组合。 该方法可以包括（1）确定四小时平均口服吗啡等价物或确定净平均小时静脉内剂量，和（2）以3：2的比例口服给予患者第一剂量的吗啡 - 羟考酮组合 每四至六小时一次。 另外，一种治疗已被静脉内施用阿片样物质的患者的疼痛的方法，包括使用给药算法来确定即时释放吗啡 - 羟考酮组合的第一剂量。
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公开(公告)号：US08012990B2
公开(公告)日：2011-09-06
申请号：US12881728
申请日：2010-09-14
IPC分类号： A01N43/42 , A01N43/38 , A01N37/10 , A61K31/44 , A61K31/40 , A61K9/28 , A61K9/20 , C07D489/00 , A61K31/19
CPC分类号： A61K31/485 , A61K2300/00
摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
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3.发明申请Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia 有权将患者的治疗方案从静脉内施用阿片样物质转变成口服给药吗啡和羟考酮的方法，使用剂量算法提供镇痛公开(公告)号：US20110086873A1
公开(公告)日：2011-04-14
申请号：US12881677
申请日：2010-09-14
IPC分类号： A61K31/485 , A61P25/04
CPC分类号： C07D489/08 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
摘要翻译： 将包括静脉内施用阿片样物质的疼痛治疗转化为疼痛治疗的方法，包括在需要镇痛的患者中口服施用第一剂量的立即释放吗啡 - 羟考酮组合。 该方法可以包括（1）确定四小时平均口服吗啡等价物或确定净平均小时静脉内剂量，和（2）以3：2的比例口服给予患者第一剂量的吗啡 - 羟考酮组合 每四至六小时一次。 另外，一种治疗已被静脉内施用阿片样物质的患者的疼痛的方法，包括使用给药算法来确定即时释放吗啡 - 羟考酮组合的第一剂量。
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