发明授权
- 专利标题： Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
- 专利标题（中）： 将患者的治疗方案从静脉内施用阿片样物质转化成口服给予吗啡和羟考酮的方法，使用计量算法提供镇痛
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申请号： US13185016申请日： 2011-07-18
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公开(公告)号： US08222267B2公开(公告)日： 2012-07-17
- 发明人: Patricia T. Richards , Warren C. Stern , Laurel J. Mengle-Gaw , Benjamin Schwartz
- 申请人： Patricia T. Richards , Warren C. Stern , Laurel J. Mengle-Gaw , Benjamin Schwartz
- 申请人地址： AU North Sydney
- 专利权人： QRxPharma Ltd.
- 当前专利权人： QRxPharma Ltd.
- 当前专利权人地址： AU North Sydney
- 代理机构： Frommer Lawrence & Haug LLP
- 代理商 Sandra Kuzmich, Esq.; Russell A. Garman
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; A01N43/38 ; A01N37/10 ; A61K31/44 ; A61K31/40 ; A61K31/19 ; A61K9/28 ; A61K9/20 ; C07D489/00
摘要：
A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents, a one-hour average oral morphine equivalents, or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
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