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19 条记录 (耗时 0.02 秒)

    A KIND OF MONITORING METHOD FOR DRINKING BEHAVIOR OF LABORATORY MICE, AND ITS SYSTEM AND DEVICE
    2.
    发明申请
    A KIND OF MONITORING METHOD FOR DRINKING BEHAVIOR OF LABORATORY MICE, AND ITS SYSTEM AND DEVICE 有权

    公开(公告)号：US20220129427A1

    公开(公告)日：2022-04-28

    申请号：US17253199

    申请日：2020-01-03

    申请人： Nanjing Medical University

    发明人： Qigang Zhou ,  Chunyu Yin ,  Dongya Zhu ,  Feng Han ,  Liandi Li ,  Peijin Xu

    IPC分类号： G06F16/215 ,  G06F16/22

    摘要： The embodiment of the present invention discloses a kind of monitoring method for drinking behavior of laboratory mice, and its system and device, and thus obtains raw data of the drinking behavior of mice, and then stores the raw data; as well as conducts data filtering on the raw data to filter out false data of jitter from the raw data, wherein, the false data of jitter consists of the data triggered by measurement signal transient and jitter caused by accidentally touch of the mice body, and their exploratory action; and then completes index statistics and analysis of the raw data filtered out false data of jitter, and thus forms indicator data, as well as stores the indicator data; after that, the indicator data is displayed in classification of real-time data, historical data and report data. The present invention utilizes the serial filtering mechanism of data filtering and matching, and thus reduces the amount of invalid trigger data, and there is no accumulated performance loss of data processing, as well as has efficient, accurate and real processing capabilities to process experimental batch data, and can provide reliable and objective statistical indicators to laboratory personnel, as well as may detect multiple laboratory mice at the same time, and thus, greatly improves the efficiency of the experiment and the accuracy of the experimental results.

    Anti-tumor polypeptides and method for preparing anti-tumor drugs comprisng the same
    5.
    发明授权
    Anti-tumor polypeptides and method for preparing anti-tumor drugs comprisng the same 有权

    公开(公告)号：US09745345B2

    公开(公告)日：2017-08-29

    申请号：US14942908

    申请日：2015-11-16

    申请人： NANJING MEDICAL UNIVERSITY

    发明人： Jianwei Zhou ,  Jin Xu ,  Xuan Li ,  Aiping Li

    IPC分类号： C07K7/06 ,  C07K7/08 ,  A61K38/00 ,  C07K14/47

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/4703

    摘要： An anti-tumor polypeptide, having an amino acid sequence represented by FPGSDRF (SEQ ID NO: 15), X-FPGSDRF (SEQ ID NO: 16), FPGSDRF-Z (SEQ ID NO: 17), or X-FPGSDRF-Z (SEQ ID NO: 18) is disclosed. The various capital letters denote amino acids: F: phenylalanine; P: proline; G: glycine; D: aspartic acid; R: arginine; S is a phosphorylated serine residue, X and Z are an amino acid residue or an amino acid sequence, respectively, X is one selected from the group consisting of F, (R)9 (SEQ ID NO: 19), (R)9-F (SEQ ID NO: 20), 6-aminocaproic acid, 6-aminocaproic acid-F, 6-aminocaproic acid-(R)9 (SEQ ID NO: 21), and 6-aminocaproic acid-(R)9-F (SEQ ID NO: 22), Z is one selected from the group consisting of A, (G)n-RGD (SEQ ID NO: 23), and A-(G)n-RGD (SEQ ID NO: 24); and n is an integer greater than or equal to 0.

    Recyclable and adjustable interventional stent for intravascular constriction
    7.
    发明授权
    Recyclable and adjustable interventional stent for intravascular constriction 有权

    公开(公告)号：US09814564B2

    公开(公告)日：2017-11-14

    申请号：US14354505

    申请日：2012-10-24

    申请人： THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY

    发明人： Shijiang Zhang ,  Weidong Gu

    IPC分类号： A61F2/06 ,  A61F2/07 ,  A61F2/90 ,  A61F2/966 ,  A61F2/95

    CPC分类号： A61F2/07 ,  A61F2/90 ,  A61F2/966 ,  A61F2002/9522 ,  A61F2002/9534 ,  A61F2002/9665 ,  A61F2210/0061 ,  A61F2230/0078 ,  A61F2250/001

    摘要： A recyclable and adjustable interventional stent for intravascular constriction. The stent main body is divided into three parts and shaped like a waist drum with expansion parts (1, 4) being arranged on the upper and lower parts of the stent main body respectively for supporting and positioning. A variable aperture part (2) is arranged in the middle of the stent main body. The upper expansion part (1) is or is not provided with a coating; the middle variable aperture part (2) and the upper half part of the lower expansion part (4) are covered with a pericardium (3) subjected to anti-calcification treatment; and a metal wire ring (5) is passed through the lowermost edge of the stent. A compound conveying guide pipe is composed of an outer sheath (6) and a core (7). The core (7) is a hollow pipe and a wire hanging groove is arranged on the outer side wall of the tip of the pipe to hang the metal wire ring (5) of the lowermost edge of the stent. A fixing bolt (8) on the outer sheath (6) is used for fixing the relative position between the outer sheath (6) and the core (7). The stent is used to replace conventional pulmonary artery banding as, adhesion not being formed around the heart and major vessels and pulmonary stenosis not being formed, difficulties during radical surgery are not increased.

    Guiding apparatus for X-ray-free screw placement by spinal posterior approach
    8.
    发明授权
    Guiding apparatus for X-ray-free screw placement by spinal posterior approach 有权
    通过脊柱后路进行X射线螺钉放置的引导装置

    公开(公告)号：US09510873B2

    公开(公告)日：2016-12-06

    申请号：US14441116

    申请日：2013-11-13

    申请人： THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY

    发明人： Xiaojian Cao ,  Haijun Li ,  Jian Tang ,  Lipeng Yu ,  Hao Xie ,  Lei Yang

    IPC分类号： A61B17/70 ,  A61B17/17 ,  A61B17/88

    CPC分类号： A61B17/7076 ,  A61B17/1757 ,  A61B17/8872

    摘要： A guiding apparatus for x-ray-free screw placement by a spinal posterior approach, comprising an interspinous spacer, a slide scale (1), and an angle-changing rod. The apparatus is simple to operate, easy to grasp, and well accepted by physicians. A reliable effect is provided in screw placement. Significantly reduced X-ray exposure is allowed for patients and medical staff. In a small-incision minimally invasive screw placement operation, even without exposing the spinal ligament, a small spike-like protrusion of a base (2) of the interspinous spacer can ensure accurate interspinous positioning across the skin. This is applicable for both minimally invasive and incision surgeries and has a wide range of uses.

    摘要翻译： 一种用于通过脊柱后路进行的用于无X射线的螺钉放置的引导装置，包括棘突间间隔物，滑动秤（1）和角度变换杆。 该设备操作简单，易于掌握，被医生广泛接受。 在螺钉安装中提供了可靠的效果。 患者和医务人员允许显着降低X射线暴露。 在小切口微创螺钉放置操作中，即使没有暴露脊椎韧带，椎间间隔垫的基部（2）的小的尖状突起可以确保穿过皮肤的精确的棘突间定位。 这适用于微创和切口手术，并且具有广泛的用途。

    RECYCLABLE AND ADJUSTABLE INTERVENTIONAL STENT FOR INTRAVASCULAR CONSTRICTION
    9.
    发明申请
    RECYCLABLE AND ADJUSTABLE INTERVENTIONAL STENT FOR INTRAVASCULAR CONSTRICTION 有权
    循环和可调节的静脉造影介入手术

    公开(公告)号：US20140303710A1

    公开(公告)日：2014-10-09

    申请号：US14354505

    申请日：2012-10-24

    申请人： THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY

    发明人： Shijiang Zhang ,  Weidong Gu

    IPC分类号： A61F2/07 ,  A61F2/90 ,  A61F2/966

    CPC分类号： A61F2/07 ,  A61F2/90 ,  A61F2/966 ,  A61F2002/9522 ,  A61F2002/9534 ,  A61F2002/9665 ,  A61F2210/0061 ,  A61F2230/0078 ,  A61F2250/001

    摘要： A recyclable and adjustable interventional stent for intravascular constriction. The stent main body is divided into three parts and shaped like a waist drum with expansion parts (1, 4) being arranged on the upper and lower parts of the stent main body respectively for supporting and positioning. A variable aperture part (2) is arranged in the middle of the stent main body. The upper expansion part (1) is or is not provided with a coating; the middle variable aperture part (2) and the upper half part of the lower expansion part (4) are covered with a pericardium (3) subjected to anti-calcification treatment; and a metal wire ring (5) is passed through the lowermost edge of the stent. A compound conveying guide pipe is composed of an outer sheath (6) and a core (7). The core (7) is a hollow pipe and a wire hanging groove is arranged on the outer side wall of the tip of the pipe to hang the metal wire ring (5) of the lowermost edge of the stent. A fixing bolt (8) on the outer sheath (6) is used for fixing the relative position between the outer sheath (6) and the core (7). The stent is used to replace conventional pulmonary artery banding as, adhesion not being formed around the heart and major vessels and pulmonary stenosis not being formed, difficulties during radical surgery are not increased.

    摘要翻译： 可回收和可调节的介入支架用于血管内收缩。 支架主体分为三部分，并形成为一个腰部鼓，其中扩张部分（1,4）分别设置在支架主体的上部和下部，用于支撑和定位。 可变开口部分（2）布置在支架主体的中间。 上部膨胀部分（1）是或不具有涂层; 中间可变孔径部分（2）和下部扩张部分（4）的上半部分被用于进行抗钙化处理的心包膜（3）覆盖; 并且金属线环（5）穿过支架的最下边缘。 复合输送导管由外护套（6）和芯（7）组成。 芯部（7）是中空管，并且在管的顶端的外侧壁上布置有线悬挂槽，以悬挂支架最下边缘的金属丝环（5）。 外护套（6）上的固定螺栓（8）用于固定外护套（6）和芯体（7）之间的相对位置。 支架用于代替常规的肺动脉带，因为未形成心脏和主要血管周围的附着物以及未形成的肺动脉狭窄，根本手术期间的困难不增加。