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公开(公告)号：US12050688B1
公开(公告)日：2024-07-30
申请号：US18443133
申请日：2024-02-15
CPC分类号： G06F21/566 , G06F2221/034
摘要： A computer device including a computing engine having a plurality of processor cores configured to simultaneously execute identical sets of processor-executable instructions, where each of the processor cores includes different instruction code assignments, and a malware monitoring and remediation component that detects presence of malware when instruction register values from a predetermined number of processor cores are identical during an instruction cycle. In various embodiments, the computer device may be an “edge” computer deployed in military or other highly-sensitive environments. The computing engine may be implemented using one or more field programmable gate arrays (FPGAs).
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公开(公告)号：US20240182988A1
公开(公告)日：2024-06-06
申请号：US18331811
申请日：2023-06-08
IPC分类号： C12Q1/70 , C12Q1/6806 , C12Q1/6818 , C12Q1/6853
CPC分类号： C12Q1/701 , C12Q1/6806 , C12Q1/6818 , C12Q1/6853
摘要： The disclosure relates to engineered systems and methods for detecting target nucleic acid in a sample, which may be a complex mixture. The systems and methods may improve sensitivity of target nucleic acid detection by enhancing signal generation. For example, signal generation may be enhanced through programmable capture and concentration of the target nucleic acid using an engineered type III CRISPR complex. Various ancillary nucleases such as Can1, Can2, and NucC are identified and may be used for detection. For example, binding of the engineered type III CRISPR complex may produce products that activate the identified ancillary nucleases. Different activators trigger changes in the substrate specificity of these nucleases. The activated nucleases may be used to detect programmatic detection of the target nucleic in the sample. The systems and methods are shown to detect viral RNA directly from nasopharyngeal swab samples.
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3.发明公开公开(公告)号：US20230243853A1
公开(公告)日：2023-08-03
申请号：US17820409
申请日：2022-08-17
发明人： Blaine Roberts , Edward A. Dratz , Scott Laffoon
CPC分类号： G01N33/6896 , A61B5/4076 , A61B5/0071 , A61B5/4082 , A61B5/4088 , G01N2333/4709 , G01N2500/04 , G01N2800/50 , G01N2800/52 , G01N2800/2821 , G01N2800/2835
摘要： The present invention provides methods for identifying biomarkers of disease capable of affecting cognitive function. The biomarkers identified by the methods of the prevention may be used for predicting whether a mammal will develop a disease capable of affecting cognitive function. More specifically, the present invention relates to the identification of biomarkers predictive of neurological diseases in a mammal and the use of these biomarkers in the diagnosis, differential diagnosis, and/or prognosis of the neurological disease. The methods and systems provided enable an assessment and theoretical prediction of neocortical amyloid loading based on the measurement of biomarkers that will provide an indication of whether a mammal is likely to develop a neurological disease.
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公开(公告)号：US20230053573A1
公开(公告)日：2023-02-23
申请号：US17814097
申请日：2022-07-21
IPC分类号： C12Q1/70
摘要： The disclosure relates to engineered systems and methods for detecting target nucleic acid in a sample, which may be a complex mixture. The systems and methods may improve sensitivity of target nucleic acid detection by enhancing signal generation. For example, signal generation may be enhanced through programmable capture and concentration of the target nucleic acid using an engineered type III CRISPR complex. Various ancillary nucleases such as Can1, Can2, and NucC are identified and may be used for detection. For example, binding of the engineered type III CRISPR complex may produce products that activate the identified ancillary nucleases. Different activators trigger changes in the substrate specificity of these nucleases. The activated nucleases may be used to detect programmatic detection of the target nucleic in the sample. The systems and methods are shown to detect viral RNA directly from nasopharyngeal swab samples.
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公开(公告)号：US20220244517A1
公开(公告)日：2022-08-04
申请号：US17717774
申请日：2022-04-11
摘要： A device for viewing a target, the device including a housing, an objective lens positioned within the housing, where the objective lens has a first lens group including at least a first lens and a second lens group including at least a second lens, the first lens positioned closer to the target than the second lens, and a camera positioned within the objective lens between the first lens and the second lens, where the camera is configured to provide images of the target located near a focal point of the objective lens, and wherein the arrangement of the first lens, the second lens, and the camera provides for simultaneous capture of a first image of a surface of the target and a second image of a sub-surface cellular structure of the target.
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公开(公告)号：US20210332446A1
公开(公告)日：2021-10-28
申请号：US17240858
申请日：2021-04-26
摘要： The disclosure relates to an engineered type III CRISPR-Cas system for sensitive and sequence specific detection of nucleic acid in a sample. For example, the engineered type III CRISPR-Cas system may be implemented as an assay for testing SARS-CoV-2 virus (or other target nucleic acid in the sample) that can be performed quickly, such as in one hour or less. Nucleic acid recognition by type III systems may trigger Cas10-mediated nuclease activity and/or polymerase activity, which may generate pyrophosphates, protons and cyclic oligonucleotides. The nuclease activity and/or the one or more products of the Cas10-polymerase are detected using colorimetric, visible fluorometric, and/or instrumented fluorometric detection.
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公开(公告)号：US20200312510A1
公开(公告)日：2020-10-01
申请号：US16954983
申请日：2018-12-14
发明人： Ryan J. Snow , Yves U. Idzerda , Elke Arenholz
摘要： Large magnetic moment compositions are formed by stabilizing ternary or other alloys with a epitaxial control layer. Compositions that are unstable in bulk specimen are thus stabilized and exhibit magnetic moments that are greater that a Slater-Pauling limit. In one example, FexCoyMnz layers are produced on an MgO(001) substrate with an MgO surface serving to control the structure of the FexCoyMnz layers. Magnetizations greater than 3 Bohr magnetons are produced.
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公开(公告)号：US20190265254A1
公开(公告)日：2019-08-29
申请号：US16284914
申请日：2019-02-25
申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services , Montana State University
IPC分类号： G01N33/68
摘要： Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described. Methods of treating subject with neurological disease, and methods of evaluating the efficacy of particular treatments, based on detection of the disclosed biomarkers are also described.
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公开(公告)号：US09931390B2
公开(公告)日：2018-04-03
申请号：US15247297
申请日：2016-08-25
IPC分类号： A61K35/747 , A61K39/108 , A61K35/744 , A23L33/135 , A61K39/00
CPC分类号： A61K39/0258 , A23L33/135 , A23V2002/00 , A61K35/744 , A61K35/747 , A61K2039/523 , A61K2039/58 , Y02A50/474
摘要： The present disclosure relates generally to therapeutic compositions comprising recombinant bacteria. Further, the disclosure elaborates upon methods of utilizing the taught therapeutic compositions to treat autoimmune and inflammatory disease. The present teachings also relate to the disclosed recombinant bacteria and methods of producing the recombinant bacteria utilized in the compositions and methods. Further taught herein are dietary supplements and food additive compositions comprising the taught recombinant bacteria.
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公开(公告)号：US20170212219A1
公开(公告)日：2017-07-27
申请号：US15139925
申请日：2016-04-27
申请人： University Corporation for Atmospheric Research , Montana State University , NASA Langley Research Center
CPC分类号： G01S7/4814 , G01N21/538 , G01N2021/1795 , G01N2021/4709 , G01S7/4812 , G01S7/4816 , G01S7/484 , G01S17/107 , G01S17/95 , Y02A90/19
摘要： A shared optics and telescope, a filter, and a micropulse differential absorption LIDAR are provided, with methods to use the same. The shared optics and telescope includes a pair of axicon lenses, a secondary mirror, a primary mirror including an inner mirror portion and an outer mirror portion, the inner mirror portion operable to expand the deflected annular transmission beam, and the outer mirror portion operable to collect the return signal. The filter includes an etalon and a first filter. The micropulse differential absorption LIDAR includes first and second laser signals, a laser transmission beam selection switch, a first laser return signal switch, and a toggle timer.
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