公开(公告)号：US20210252072A1

公开(公告)日：2021-08-19

申请号：US16973108

申请日：2019-06-13

申请人： LOMA LINDA UNIVERSITY ,  LOMA LINDA UNIVERSITY MEDICAL CENTER ,  FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE

发明人： Huynh CAO ,  Yi XU ,  Kimberly PAYNE ,  David BAYLINK

IPC分类号： A61K35/28 ,  C12N5/0789

摘要： In one aspect, engineered hematopoietic stem cells comprising a heterologous expression cassette are provided. In some embodiments, the expression cassette comprises a promoter operably linked to a polynucleotide that encodes a 1α-hydroxylase protein, wherein the 1α-hydroxylase protein is human cytochrome P450 family 27 subfamily B member 1 (CYP27B1).

公开(公告)号：US09364205B2

公开(公告)日：2016-06-14

申请号：US13226398

申请日：2011-09-06

申请人： Yong Hua Zhu ,  Wolff M. Kirsch

发明人： Yong Hua Zhu ,  Wolff M. Kirsch

IPC分类号： A61B17/00 ,  A61B17/02

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B17/02 ,  A61B2017/00637 ,  A61B2017/00654

摘要： A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

摘要翻译： 用于闭合血管伤口的方法和装置包括可以在导线上或与伤口相邻就位的导线上穿过的装置。 该装置包括在其中封闭止血材料的腔室。 当根据需要将装置定位在伤口附近时，止血材料从腔室展开。 血液接触止血材料，血液凝固优选由材料内的止血剂促进。 因此，血管穿刺伤口被血块形成密封。

公开(公告)号：US08981324B2

公开(公告)日：2015-03-17

申请号：US14062732

申请日：2013-10-24

申请人： Loma Linda University Medical Center

发明人： Nickolas S. Rigney ,  Daniel C. Anderson ,  David A. Lesyna ,  Daniel W. Miller ,  Michael F. Moyers ,  Chieh C. Cheng ,  Michael A. Baumann

IPC分类号： A61N5/00 ,  G21G5/00 ,  A61N5/10 ,  B25J9/16 ,  A61B6/04 ,  A61B19/00 ,  A61B6/00

CPC分类号： A61N5/107 ,  A61B6/0442 ,  A61B6/4092 ,  A61B6/547 ,  A61B2090/3937 ,  A61N5/1037 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/1078 ,  A61N2005/105 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1087 ,  A61N2005/1097 ,  B25J9/1666 ,  G05B15/02 ,  G05B2219/45117

摘要： A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.

摘要翻译： 用于放射治疗系统的患者对准系统。 对准系统包括多个外部测量装置，其获得可移动和/或经受弯曲或其它位置变化的辐射治疗系统的部件的位置测量。 对准系统采用外部测量来提供校正定位反馈，以更精确地对准患者并将其与辐射束对准。 对准系统可以作为放射治疗系统的组成部分提供，或者可以作为现有放射治疗系统的升级来添加。

公开(公告)号：US08784846B2

公开(公告)日：2014-07-22

申请号：US12694642

申请日：2010-01-27

申请人： Reinhard Schulte ,  Gilmer Valdes-Diaz

发明人： Reinhard Schulte ,  Gilmer Valdes-Diaz

IPC分类号： A61K51/00 ,  A61K49/00 ,  A61K9/00 ,  A61K9/14

CPC分类号： A61K9/14 ,  A61K47/02 ,  A61N5/1042 ,  A61N2005/1052 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1098 ,  C07K16/18

摘要： Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.

摘要翻译： 用于增强靶标选择性靶向的系统和方法，用于在目标组织远端的健康组织减少作用的靶上优先作用。 一种或多种药剂可以与纳米级结构/颗粒结合以递送至靶组织。 用加速的粒子辐射（例如质子辐射）进行适当的轰击诱导药剂在目标部位的释放。 纳米载体可与治疗和/或成像增强剂组合。 目标组织的成像可以提供粒子辐射的递送剂量的验证。 纳米载体可以具有选择用于体内环境中的生物相容性和耐久性的外壳，并进一步选择在治疗环境中提供反馈机制以加速药剂的释放并减少该释放所需的总辐射剂量。

公开(公告)号：US08473608B2

公开(公告)日：2013-06-25

申请号：US12861508

申请日：2010-08-23

申请人： Michael A Baumann ,  Alexandre V Beloussov ,  Julide Bakir ,  Deganit Armon ,  Howard B Olsen ,  Dana Salem

发明人： Michael A Baumann ,  Alexandre V Beloussov ,  Julide Bakir ,  Deganit Armon ,  Howard B Olsen ,  Dana Salem

IPC分类号： G06F15/173 ,  A61N5/00

摘要： A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

公开(公告)号：US20130150645A1

公开(公告)日：2013-06-13

申请号：US13188641

申请日：2011-07-22

申请人： Michael F. Moyers

发明人： Michael F. Moyers

IPC分类号： A61N5/10 ,  A61B6/03 ,  A61B5/055

CPC分类号： A61N5/10 ,  A61B5/055 ,  A61B6/037 ,  A61B90/18 ,  A61N5/1039 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1097

摘要： Support devices and pods for the head and neck region of patients undergoing radiation therapy are provided herein. The pod generally includes a support shell shaped to generally conform to the shape of the head and neck region of the patient, a foam insert that conforms to the head and neck region of the patient, and an immobilization facemask attached directly to the shell, thereby facilitating close placement of the radiation beam delivery device to the patient and reducing any attenuation and perturbation of radiation doses directed at the patient. The components of the pod are made from materials having properties that reduce any attenuation and perturbation of prescribed radiation doses.

摘要翻译： 本文提供了用于接受放射治疗的患者的头颈部区域的支撑装置和荚。 所述荚通常包括形状为大致符合患者的头部和颈部区域的形状的支撑壳体，符合患者的头部和颈部区域的泡沫插入物以及直接附接到壳体上的固定面罩，由此 促进辐射束输送装置向患者的近距离放置，并减少针对患者的辐射剂量的任何衰减和扰动。 荚的组件由具有减少规定辐射剂量的任何衰减和扰动性质的材料制成。

公开(公告)号：US08418288B2

公开(公告)日：2013-04-16

申请号：US13345090

申请日：2012-01-06

申请人： Daniel W. Miller ,  Steve K. McAllaster ,  Jerry D. Slater ,  Nickolas S. Rigney ,  Daniel C. Anderson ,  Michael F. Moyers

发明人： Daniel W. Miller ,  Steve K. McAllaster ,  Jerry D. Slater ,  Nickolas S. Rigney ,  Daniel C. Anderson ,  Michael F. Moyers

IPC分类号： A61G7/07

CPC分类号： A61N5/107 ,  A61B6/0442 ,  A61B6/4092 ,  A61B6/547 ,  A61B2090/3937 ,  A61N5/1037 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/1078 ,  A61N2005/105 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1087 ,  A61N2005/1097 ,  B25J9/1666 ,  G05B15/02 ,  G05B2219/45117

摘要： A radiation treatment system (100) for accurately delivering radiation to a targeted site within a cancer patient (108) that includes a modular patient support system and a patient positioner (114). The modular patient support system includes a modularly expandable patient pod (200) and at least one immobilization device, such as, for example, a rigid moldable foam cradle (350). The patient pod (200) includes a generally hemi-cylindrical support shell (212) that extends longitudinally between proximal edge (214) and distal edge (216), and transversely between two lateral edges (222, 224). In one embodiment, the lateral edges (222, 224) are tapered to minimize edge effects that result when radiation beams traverse the lateral edges (222, 224).

摘要翻译： 1.一种辐射治疗系统（100），用于将辐射准确地传送到癌症患者（108）内的目标部位，其包括模块化患者支撑系统和患者定位器（114）。 模块化患者支撑系统包括模块化可扩展的患者支架（200）和至少一个固定装置，例如刚性可模制泡沫支架（350）。 患者荚（200）包括在近端边缘（214）和远端边缘（216）之间纵向延伸且横向于两个横向边缘（222,224）之间延伸的大致半圆柱形的支撑壳体（212）。 在一个实施例中，横向边缘（222,224）是锥形的，以最小化当辐射束横穿横向边缘（222,224）时产生的边缘效应。

公开(公告)号：US20120331573A1

公开(公告)日：2012-12-27

申请号：US13457352

申请日：2012-04-26

申请人： Wolff M. Kirsch ,  Matthew Schrag ,  Andrew Crofton ,  Matthew Zabel

发明人： Wolff M. Kirsch ,  Matthew Schrag ,  Andrew Crofton ,  Matthew Zabel

IPC分类号： G01N33/566 ,  G01N27/62 ,  H01J49/26 ,  A01K67/027 ,  C12N5/10 ,  C40B30/04 ,  C12Q1/02

CPC分类号： G01N33/5058 ,  G01N33/566 ,  G01N33/84 ,  G01N2500/10 ,  G01N2800/2821

摘要： Methods and kits for identifying neurological conditions in a patient by determining a level of expression of dynactin subunit p62 are disclosed. The neurological conditions may include, for example, Alzheimer's Disease (AD) without cerebral amyloid angiopathy (CAA).

摘要翻译： 公开了通过确定dynactin亚单位p62的表达水平来鉴定患者神经系统状况的方法和试剂盒。 神经学病症可以包括例如没有脑淀粉样血管病（CAA）的阿尔茨海默病（AD）。

公开(公告)号：US20120059410A1

公开(公告)日：2012-03-08

申请号：US13226398

申请日：2011-09-06

申请人： Yong Hua Zhu ,  Wolff M. Kirsch

发明人： Yong Hua Zhu ,  Wolff M. Kirsch

IPC分类号： A61B17/03

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B17/02 ,  A61B2017/00637 ,  A61B2017/00654

摘要： A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

摘要翻译： 用于闭合血管伤口的方法和装置包括可以在导线上或与伤口相邻的位置上穿过导线的装置。 该装置包括在其中封闭止血材料的腔室。 当根据需要将装置定位在伤口附近时，止血材料从腔室展开。 血液接触止血材料，血液凝固优选由材料内的止血剂促进。 因此，血管穿刺伤口被血块形成密封。

公开(公告)号：US20110266262A1

公开(公告)日：2011-11-03

申请号：US12957197

申请日：2010-11-30

申请人： Paul E. Denney ,  Jay R. Eastman ,  Ta-Chieh Huang

发明人： Paul E. Denney ,  Jay R. Eastman ,  Ta-Chieh Huang

IPC分类号： B23K26/04

CPC分类号： B23K26/032 ,  B23K26/03 ,  B23K26/034 ,  B23K26/043 ,  B23K26/12 ,  B23K26/123 ,  B23K26/128 ,  B23K26/142 ,  B23K26/16 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/28

摘要： A system and method processes a structure comprising embedded material. The system includes a laser adapted to generate light and to irradiate an interaction region of the structure. The system further includes an optical system adapted to receive light from the interaction region and to generate a detection signal indicative of the presence of embedded material in the interaction region. The system further includes a controller operatively coupled to the laser and the optical system. The controller is adapted to receive the detection signal and to be responsive to the detection signal by selectively adjusting the laser.

摘要翻译： 系统和方法处理包括嵌入材料的结构。 该系统包括适于产生光并照射结构的相互作用区域的激光器。 该系统还包括适于接收来自相互作用区域的光并且产生指示在相互作用区域中存在嵌入材料的检测信号的光学系统。 该系统还包括可操作地耦合到激光器和光学系统的控制器。 控制器适于接收检测信号，并通过选择性调节激光来响应检测信号。