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公开(公告)号：US12031157B2
公开(公告)日：2024-07-09
申请号：US17810537
申请日：2022-07-01
IPC分类号： C12N5/0783 , A01N1/02 , A61K35/17 , C12N9/22 , C12N15/113
CPC分类号： C12N5/0638 , A01N1/0221 , A01N1/0226 , A61K35/17 , C12N9/22 , C12N15/113 , C12N2310/20 , C12N2501/2302 , C12N2501/2315 , C12N2501/2321 , C12N2501/515
摘要： The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. The methods may comprise gene-editing at least a portion of the TILs to enhance their therapeutic efficacy. Such TILs find use in therapeutic treatment regimens.
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2.发明公开公开(公告)号：US20240133871A1
公开(公告)日：2024-04-25
申请号：US18474824
申请日：2023-09-26
CPC分类号： G01N33/505 , A61K9/0019 , A61K38/2013 , A61K39/4611 , A61K39/4644 , A61P35/00 , C12N5/0636 , G01N33/6863 , C12N2501/2302 , C12N2501/515 , C12N2502/30 , G01N2333/555
摘要： The present invention provides novel processes, compositions, and methods for analyzing or assaying the potency and/or functionality of tumor infiltrating lymphocyte (TIL) products for use in therapy, including human cancer therapy, and analyzing or assaying the potency and/or functionality of other polyclonal products, such as marrow infiltrating lymphocyte (MIL) and peripheral blood lymphocyte (PBL) products. Compositions, methods, and kits for preparing and treating cancer using TIL, MIL, and PBL products are also provided.
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公开(公告)号：US20230392102A1
公开(公告)日：2023-12-07
申请号：US18249380
申请日：2021-10-22
发明人： Seth Wardell , Joseph James Wypych
摘要： A gas permeable cell culture device including a container body defining an interior volume, the container body having a semi-permeable membrane defining one end of the interior volume, a fitting defining an opposing end of the interior volume, and a cell transfer conduit. The cell transfer conduit having an open end positioned within the interior volume between the semi-permeable membrane and the fitting and a radial portion disposed within the interior volume and between the open end and opposing end of the container body.
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公开(公告)号：US11713446B2
公开(公告)日：2023-08-01
申请号：US17736953
申请日：2022-05-04
IPC分类号： C12N5/0783 , A61K35/17
CPC分类号： C12N5/0638 , A61K35/17 , C12N2501/2302 , C12N2501/2315 , C12N2501/2321 , C12N2501/515 , C12N2501/998 , C12N2502/11
摘要： The present invention provides improved and/or shortened processes and methods for reprogramming TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy. Such reprogrammed TILs find use in therapeutic treatment regimens.
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5.发明公开公开(公告)号：US20230187042A1
公开(公告)日：2023-06-15
申请号：US18050353
申请日：2022-10-27
CPC分类号： G16H20/00 , A61K35/12 , C12N5/0693 , G06Q10/0832 , G16H10/60 , G16H80/00
摘要： A method for coordinating the manufacturing of an expanded cell therapy product for a patient may include receiving a cell order request to expand the cell therapy product for the patient; generating a patient-specific identifier or cell order identifier associated with the cell order request; and initiating a process to expand the cell therapy product from at least some of a solid tumor obtained from the patient. If acceptance parameters for the expansion cell therapy product do not meet certain acceptance criteria at a second time point subsequent to a first time point in the expansion process, it is determined whether re-performing the expansion of the cell therapy product using the cell expansion technique is possible from the first time point based on the acceptance parameters at the second time point. If such re-performing the expansion is possible, patient treatment events that use the expanded cell therapy product are rescheduled.
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6.发明授权公开(公告)号：US11631483B2
公开(公告)日：2023-04-18
申请号：US17570195
申请日：2022-01-06
发明人： Anne Brooks , Steve Macrides , Kristin Lanzi
摘要： A method for coordinating the manufacturing of an expanded cell therapy product for a patient may include receiving a cell order request to expand the cell therapy product for the patient; generating a patient-specific identifier or cell order identifier associated with the cell order request; and initiating a process to expand the cell therapy product from at least some of a solid tumor obtained from the patient. If acceptance parameters for the expansion cell therapy product do not meet certain acceptance criteria at a second time point subsequent to a first time point in the expansion process, it is determined whether re-performing the expansion of the cell therapy product using the cell expansion technique is possible from the first time point based on the acceptance parameters at the second time point. If such re-performing the expansion is possible, patient treatment events that use the expanded cell therapy product are rescheduled.
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7.发明申请公开(公告)号：US20230045899A1
公开(公告)日：2023-02-16
申请号：US17817273
申请日：2022-08-03
发明人： Seth Wardell , James Bender , Michael T. Lotze
IPC分类号： A61K35/17 , A61K38/20 , A61K31/675 , A61K31/7076 , A61P35/00 , A61K9/00 , A01N1/02 , C12N5/078 , C12N5/0783
摘要： The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
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8.发明申请公开(公告)号：US20230021312A1
公开(公告)日：2023-01-26
申请号：US17823454
申请日：2022-08-30
发明人： Seth Wardell , James Bender
IPC分类号： A61K35/17 , A61K38/20 , A61K31/675 , A61K31/7076 , A61P35/00 , A61K9/00 , A01N1/02 , C12N5/078 , C12N5/0783
摘要： The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
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9.发明授权公开(公告)号：US11529372B1
公开(公告)日：2022-12-20
申请号：US17817281
申请日：2022-08-03
发明人： Seth Wardell , James Bender , Michael T. Lotze
IPC分类号： A61K35/17 , A61K38/20 , A61K31/675 , A61K31/7076 , A61P35/00 , A61K9/00 , A01N1/02 , C12N5/078 , C12N5/0783 , A61K38/21 , A61K39/00
摘要： The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
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10.发明申请公开(公告)号：US20220378838A1
公开(公告)日：2022-12-01
申请号：US17856800
申请日：2022-07-01
发明人： Seth Wardell , James Bender , Michael T. Lotze
IPC分类号： A61K35/17 , A61K38/20 , A61K31/675 , A61K31/7076 , A61P35/00 , A61K9/00 , A01N1/02 , C12N5/078 , C12N5/0783
摘要： The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
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