公开(公告)号：US20250064034A1

公开(公告)日：2025-02-27

申请号：US18948566

申请日：2024-11-15

Applicant: HUASHAN HOSPITAL AFFILIATED TO FUDAN UNIVERSITY

Inventor： Peimin YU ,  Xiantao LI ,  Yimin SUN ,  Lan XU ,  Yue WANG

IPC: A01K67/0278 ,  A61B5/00 ,  A61B5/383 ,  C12N9/22 ,  C12N15/11 ,  C12N15/66 ,  C12Q1/686 ,  C12Q1/6888

Abstract: A genetically-modified rat having a PKHD1L1 gene with a point or other mutation and a construction method thereof are disclosed. A CRISPR/Cas9 system knocks the PKHD1L1 gene into a mouse source, and a codon changes from TTA to TCA to construct the mutant PKHD1L1 gene. The genetically-modified rat can be applied to epilepsy pathogenesis studies and design and testing of new anti-epileptic drugs. Methods for detecting abnormal cortical excitability and detecting an epileptic phenotype of an animal can use the genetically-modified rat. A somatosensory evoked potential is used to detect whether the genetically-modified rat has an abnormal cortical excitability phenotype, so as to confirm whether the rat can be a successful model for testing anti-epileptic drugs. The method can detect abnormal cortical excitability and verify the effectiveness of anti-epileptic drugs or treatments.

公开(公告)号：US20250044224A1

公开(公告)日：2025-02-06

申请号：US18920671

申请日：2024-10-18

Applicant: HUAWEI TECHNOLOGIES CO., LTD. ,  Fudan University

Inventor： Li Zheng ,  Wenbin Cai ,  Yicai Wu ,  Zijie Mao

IPC: G01N21/3577

Abstract: A substance component detection apparatus and a method are provided to reduce absorption of an infrared signal by a window medium, thereby obtaining abundant fingerprint region signals. The apparatus includes: a sample pool, an infrared optical window, an infrared light source, and a detector. The infrared optical window has a first surface that faces an inner side of the sample pool and that is configured to be in contact with a to-be-detected substance, and a second surface exposed on an outer side of the sample pool. A protruding portion is formed between two adjacent grooves on the second surface, and any protruding portion has an incident surface and an emergent surface. An infrared signal emitted by the infrared light source is irradiated on the incident surface. The detector determines a component of the to-be-detected substance and/or content of the component.

公开(公告)号：US12194428B2

公开(公告)日：2025-01-14

申请号：US17467377

申请日：2021-09-06

Applicant: Fudan University

Inventor： Fener Chen ,  Dang Cheng ,  Minjie Liu ,  Huashan Huang ,  Meifen Jiang ,  Jiaqi Wang

IPC: B01F35/00 ,  B01F33/30 ,  B01F35/53

Abstract: A multi-layered micro-channel mixer includes a base plate and a cover plate. Two inlet fluid reservoirs, two inlet channels, two groups of fluid distribution channel networks, two groups of process fluid channels, an impinging stream mixing chamber, a fluid mixing intensification channel and an outlet buffer reservoir are provided on the base plate. Two fluids are fed into the two inlet fluid reservoirs, respectively. The fluids then flow into the process fluid channels via the inlet channels and the multi-stage fluid distribution channel networks, respectively. Then the two fluid streams ejected from the opposing process fluid channels impinges upon each other in the impinging stream mixing chamber. The mixed fluid is subjected to vortex or secondary flow generated by the baffles or the internals in the impinging stream mixing chamber and fluid mixing intensification channel, and finally the mixed fluid is discharged through the outlet buffer reservoir.

公开(公告)号：US20240321999A1

公开(公告)日：2024-09-26

申请号：US18024277

申请日：2022-07-08

Applicant: Fudan University

Inventor： Jianlu WANG ,  Guangjian WU

IPC: H01L29/51 ,  G06N3/06 ,  H01L31/113 ,  H01L31/18

CPC classification number: H01L29/516 ,  G06N3/06 ,  H01L31/1136 ,  H01L31/18

Abstract: The present invention relates to a photo-response detector, in particular to a ferroelectric field modulated positive and negative photo-response detector, a preparation method and application thereof. The ferroelectric field modulated positive and negative photo-response detector includes a substrate, a gate electrode, a ferroelectric layer, a low-dimensional semiconductor and a source-drain electrode. A pair of gate electrodes are provided and fixedly arranged on the substrate at intervals. The ferroelectric layer is fixedly arranged on the substrate and completely covers the gate electrode. The low-dimensional semiconductor is fixedly arranged on the ferroelectric layer. The source-drain electrode includes a source electrode and a drain electrode separately arranged on two sides of the low-dimensional semiconductor and fixedly arranged on the ferroelectric layer.

公开(公告)号：US20240321578A1

公开(公告)日：2024-09-26

申请号：US18680924

申请日：2024-05-31

Applicant: Fudan University

Inventor： Liwei LIU ,  Zhenggang CAI ,  Siwei XUE ,  Peng ZHOU

IPC: H01L21/02 ,  H01L29/786

CPC classification number: H01L21/02568 ,  H01L21/02499 ,  H01L21/0262 ,  H01L29/78681

Abstract: A method for preparing a wafer-scale two-dimensional (2D) material array includes the following steps. Water and alcohol solvent are mixed to obtain a mixed solution. A polydimethylsiloxane (PDMS) stamp with micro posts is prepared. A monolayer two-dimensional transition metal dichalcogenides (2D-TMDs) film is continuously grown on a growth substrate. The PDMS stamp is put upside down to allow the micro posts to adhere to the monolayer 2D-TMDs film, so as to obtain a PDMS stamp-2D-TMDs film-growth substrate combination. The PDMS stamp-2D-TMDs film-growth substrate combination is immersed in the mixed solution to separate the monolayer 2D-TMDs film from the growth substrate. A portion of the monolayer 2D-TMDs film which is not in contact with upper surfaces of the micro posts is removed to obtain a patterned 2D-TMDs film. The patterned 2D-TMDs film is transferred to a target substrate to obtain the wafer-scale 2D material array.

公开(公告)号：US12055555B2

公开(公告)日：2024-08-06

申请号：US17501121

申请日：2021-10-14

Applicant: FUDAN UNIVERSITY

Inventor： Qing Li ,  Anlin Liu

IPC: G01N35/00 ,  B01D5/00 ,  B08B9/032 ,  G01N33/00 ,  G01N35/10

CPC classification number: G01N35/00584 ,  B01D5/0012 ,  B01D5/0051 ,  B01D5/0072 ,  B01D5/0096 ,  B08B9/0325 ,  B08B9/0328 ,  G01N33/0036 ,  G01N35/10 ,  B08B2209/032 ,  G01N2035/00445 ,  G01N2035/00475

Abstract: An on-line measurement system for aerosol precursors emitted from industrial sources has three parts: online measurement part, pipeline cleaning part and automatic control part. The system includes: a particulate filter, high temperature intake pipe, two detergent tanks, an air pump, a cooling water pump, two detergent pumps, a condenser, an impinger, a cooling water meter, a salinity meter, a liquid flow meter, a gas flow meter, nitrogen cylinders, connecting pipes, control valves, computer control program etc. The aerosol precursor concentration Cg emitted from industrial sources is measured in the online measurement section. After every measurement, the pipeline is cleaned by the pipeline cleaning part to remove organic and inorganic residual. The automatic control part is controlled by the computer through a controlling program to control the working process of the system. The system has small area occupation, low investment cost, simple maintenance, convenient transformation and high applicability.

公开(公告)号：US20240246820A1

公开(公告)日：2024-07-25

申请号：US18625907

申请日：2024-04-03

Applicant: Fudan University

Inventor： Fener CHEN ,  Minjie LIU ,  Li WAN ,  Yajiao ZHANG ,  Dang CHENG

IPC: C01B21/46 ,  B01D1/00 ,  B01D5/00

CPC classification number: C01B21/46 ,  B01D1/0082 ,  B01D5/006 ,  B01D5/0075

Abstract: A method for on-line continuous recovery of excess nitric acid in nitration reaction is provided. Nitration reaction liquid and nitrogen gas are simultaneously conveyed to a mixer, mixed and transferred to a temperature-controlled corrosion-resistant column for on-line continuous evaporation, where the nitration reaction liquid enters the temperature-controlled corrosion-resistant column from a top end, and the waste gas and excess nitric acid are discharged from a top port of the temperature-controlled corrosion-resistant column, and nitric acid is recovered. The nitric acid-free liquid is discharged from a bottom end of the temperature-controlled corrosion-resistant column by a pump.

公开(公告)号：US12009809B2

公开(公告)日：2024-06-11

申请号：US17828800

申请日：2022-05-31

Applicant: Fudan University

Inventor： Min Xu ,  Jian Jin ,  Mengyuan Sun ,  Bin Wang ,  Wei Zhang

IPC: H03K17/16

CPC classification number: H03K17/161

Abstract: The present invention provides a drive module for a GaN transistor, including: a first pull-down transistor and a gate ringing and overshoot suppression unit, where the gate ringing and overshoot suppression unit and a first end of the first pull-down transistor are directly or indirectly connected to a gate of the GaN transistor, the gate ringing and overshoot suppression unit is connected between a second end of the first pull-down transistor and the ground; the gate ringing and overshoot suppression unit is configured to: when a gate voltage of the GaN transistor drops, control the release of a gate charge of the GaN transistor with a first impedance if the gate voltage is higher than a specified threshold; and control the release of the gate charge of the GaN transistor with a second impedance if the gate voltage is less than the specified threshold, where the first impedance is less than the second impedance.

公开(公告)号：US20240034776A1

公开(公告)日：2024-02-01

申请号：US18034568

申请日：2021-10-29

Applicant: FUDAN UNIVERSITY ,  BIOTROY THERAPEUTICS

Inventor： Jie XU ,  Shouyan DENG ,  Teng SONG ,  Yiting WANG ,  Yungang WANG ,  Huanbin WANG ,  Hao CHI

IPC: C07K16/18 ,  A61K38/46 ,  A61K31/7088 ,  C12N15/113 ,  A61K48/00 ,  A61K38/17 ,  C07K14/47 ,  A61P35/00 ,  G01N33/574

CPC classification number: C07K16/18 ,  A61K38/465 ,  A61K31/7088 ,  C12N15/113 ,  A61K48/005 ,  A61K38/1709 ,  C07K14/47 ,  A61P35/00 ,  G01N33/57488 ,  C07K2317/24 ,  C07K2317/92 ,  C07K2317/76 ,  C07K2317/31

Abstract: Provided is a use of a regulator of ITPRIPL1 in the preparation of a drug that regulates immune responses or resists tumors, the regulator being used to increase or decrease the expression or function of the ITPRIPL1 gene or protein in an organism. Also provided is a pharmaceutical composition, which comprises the regulator used in the use. Also provided are an isolated ITPRIPL1 recombinant protein and an antibody that recognizes and binds to the ITPRIPL1. On the basis of the principle that an ITPRIPL1 protein binds to CD3ε and NRP2 receptors to regulate the functions of different immune cells, and then participates in the regulation of immune responses and a process of immune evasion of a tumor, it is confirmed that a regulator of ITPRIPL1 may be used to prepare a drug or a pharmaceutical composition, and may be applied to suppress tumors, autoimmune disease, transplant rejection, allergies and infections and other diseases.

公开(公告)号：US11887912B2

公开(公告)日：2024-01-30

申请号：US17052853

申请日：2020-07-02

Applicant: FUDAN UNIVERSITY ,  SHANGHAI INTEGRATED CIRCUIT MANUFACTURING INNOVATION CENTER CO., LTD

Inventor： Bao Zhu ,  Lin Chen ,  Qingqing Sun ,  Wei Zhang

IPC: H01L23/48 ,  H01L21/768 ,  H01L21/265 ,  H01L21/3065

CPC classification number: H01L23/481 ,  H01L21/76841 ,  H01L21/76898

Abstract: The present disclosure belongs to the technical field of integrated circuit packaging, and specifically relates to a through silicon via structure for three-dimensional integrated circuit packaging and a manufacturing method thereof. The method of the present disclosure includes the following steps: lifting off a silicon wafer by implanting hydrogen ions into the silicon wafer to obtain a substrate for making a through silicon via; performing double-sided plasma etching on the substrate to form a through silicon via penetrating the substrate; depositing an insulating medium, a copper diffusion barrier layer, and a seed layer; and removing parts of the copper diffusion barrier layer and the seed layer by photolithography and etching processes, leaving only parts of the copper diffusion barrier layer and the seed layer on a sidewall of the through silicon via; forming a sacrificial layer on the upper and lower surfaces of the resulting structure, completely filling in the through silicon via with conductive metal material, and then removing the sacrificial layer, upper and lower surfaces of the conductive metal material respectively protruding from upper and lower surfaces of the insulating medium; and forming a contact pad on a surface of the conductive metal material. The present disclosure can effectively improve production efficiency and lower the cost.