公开(公告)号：US20240341670A1

公开(公告)日：2024-10-17

申请号：US18752120

申请日：2024-06-24

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio

IPC: A61B5/00 ,  A61B5/11 ,  A61B5/316 ,  A61B5/346 ,  A61B5/372

CPC classification number: A61B5/4094 ,  A61B5/316 ,  A61B5/346 ,  A61B5/372 ,  A61B5/1117

Abstract: We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

公开(公告)号：US11957909B2

公开(公告)日：2024-04-16

申请号：US16693261

申请日：2019-11-23

Applicant: Ivan Osorio

Inventor： Ivan Osorio

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36064 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36185 ,  A61N1/0556 ,  A61N1/36117

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US20230302279A1

公开(公告)日：2023-09-28

申请号：US18133091

申请日：2023-04-11

Applicant: Ivan Osorio

Inventor： Ivan Osorio

IPC: A61N1/36

CPC classification number: A61N1/36064 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36185 ,  A61N1/0556

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US11766565B2

公开(公告)日：2023-09-26

申请号：US16679216

申请日：2019-11-10

Applicant: Ivan Osorio

Inventor： Ivan Osorio

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36064 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36185 ,  A61N1/0556 ,  A61N1/36117

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US11272874B2

公开(公告)日：2022-03-15

申请号：US16729689

申请日：2019-12-30

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/11 ,  A61B5/113 ,  A61B5/318 ,  A61B5/021 ,  A61N1/36 ,  A61B5/026 ,  A61B5/0245 ,  A61N1/365 ,  A61B5/024 ,  A61B5/0531 ,  A61B7/04 ,  A61B8/08 ,  A61B5/389

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US20200375525A1

公开(公告)日：2020-12-03

申请号：US16996335

申请日：2020-08-18

Applicant: Ivan Osorio ,  Mark Frei

Inventor： Ivan Osorio ,  Mark Frei

IPC: A61B5/00 ,  A61B5/024 ,  A61N1/36 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/04 ,  A61B5/0456 ,  A61B5/0245

Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.

公开(公告)号：US20200324115A1

公开(公告)日：2020-10-15

申请号：US16911592

申请日：2020-06-25

Applicant: IVAN OSORIO

Inventor： IVAN OSORIO

IPC: A61N1/36

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US10682515B2

公开(公告)日：2020-06-16

申请号：US15437155

申请日：2017-02-20

Applicant: FLINT HILLS SCIENTIFIC, L.L.C.

Inventor： Ivan Osorio

IPC: A61N1/36 ,  A61N1/05

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US10172550B2

公开(公告)日：2019-01-08

申请号：US14581662

申请日：2014-12-23

Applicant: Flint Hills Scientific, LLC

Inventor： Ivan Osorio

IPC: A61B5/00 ,  A61B5/16 ,  A61B5/11 ,  A61B5/0205 ,  A61B5/0488 ,  G06F19/00 ,  G16H50/30 ,  G16H50/70 ,  G16H50/20 ,  A61B5/01 ,  A61B5/053 ,  A61B5/08

Abstract: Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

公开(公告)号：US20180296155A1

公开(公告)日：2018-10-18

申请号：US16015713

申请日：2018-06-22

Applicant: IVAN OSORIO

Inventor： IVAN OSORIO

IPC: A61B5/00 ,  A61B5/024 ,  A61B5/0205 ,  G06F19/00

Abstract: We report a method for detecting epileptic or non-epileptic seizures, comprising: receiving a heart rate of a patient; calculating a percentage change of the heart rate in reference to at least one of the patient's maximal heart rate, reserve heart rate, or a resting heart rate; detecting an epileptic seizure if the percentage increase in the heart rate reaches a threshold value; and taking at least one responsive action selected from issuing a warning, delivering a therapy, determining a seizure severity, or logging at least one of a date and time of occurrence of the seizure, its severity, the type of therapy, or its effect, in response to the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.