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    METHOD FOR DETERMINING LIKELIHOOD OF COLORECTAL CANCER DEVELOPMENT
    1.
    发明申请
    METHOD FOR DETERMINING LIKELIHOOD OF COLORECTAL CANCER DEVELOPMENT 有权

    公开(公告)号：US20220022851A1

    公开(公告)日：2022-01-27

    申请号：US17500346

    申请日：2021-10-13

    申请人： Hanumat Co., Ltd. ,  EA Pharma Co., Ltd.

    发明人： Masato KUSUNOKI ,  Yuji TOIYAMA ,  Koji TANAKA ,  Toshimitsu ARAKI ,  Akira MITSUI ,  Kenji TAKEHANA ,  Tsutomu UMEZAWA

    IPC分类号： A61B10/04 ,  A61B10/06 ,  A61B17/02

    摘要： The present invention provides a method for determining the likelihood of colorectal cancer development in a human ulcerative colitis patient, the method including: a measurement step of measuring methylation rates of one or more CpG sites present in specific differentially methylated regions in DNA recovered from a biological sample collected from the human ulcerative colitis patient; and a determination step of determining the likelihood of colorectal cancer development in the human ulcerative colitis patient based on average methylation rates of the differentially methylated regions which are calculated based on the methylation rates measured in the measurement step and a preset reference value or a preset multivariate discrimination expression, in which the reference value is a value for identifying a cancerous ulcerative colitis patient and a non-cancerous ulcerative colitis patient, which is set for the methylation rate of each differentially methylated region, and the multivariate discrimination expression includes, as variables, average methylation rates of one or more differentially methylated regions among the specific differentially methylated regions.

    DRUG FOR TREATING DISORDERS OF CORNEAL EPITHELIUM
    2.
    发明申请
    DRUG FOR TREATING DISORDERS OF CORNEAL EPITHELIUM 有权

    公开(公告)号：US20210206773A1

    公开(公告)日：2021-07-08

    申请号：US17212707

    申请日：2021-03-25

    申请人： EA PHARMA CO., LTD.

    发明人： Tohru MIZUSHIMA ,  Hiroshi IWATA

    IPC分类号： C07D487/04 ,  A61K31/5517 ,  A61P27/02 ,  A61K31/551

    摘要： A new agent for the treatment of a corneal epithelium disorder, which acts directly on corneal epithelial cells, is provided. Disclosed is an agent for the treatment of a corneal epithelium disorder, the agent comprising a compound of Formula (1) or a salt thereof as an active ingredient: wherein A is an aromatic ring, a heterocyclic ring, or an aliphatic ring; R2, R3, and R4, which may be identical or different, each independently are, for example, a hydrogen atom, a halogen atom; B is an aromatic ring which may have a substituent, a heterocyclic ring which may have a substituent, or an aliphatic ring which may have a substituent; —X—, —Y—, and —Z—, which may be identical or different, each independently are O—, —NH—, —NR5—, —S—, —SO—, —SO2—, —CH2—, —CR6R7—, or —CO—; and —W— is —NR1—, —O—, or —CR8R9—.

    Multi-cell container
    3.
    发明授权
    Multi-cell container 有权

    公开(公告)号：US10226400B2

    公开(公告)日：2019-03-12

    申请号：US13892783

    申请日：2013-05-13

    申请人： EA Pharma Co., Ltd.

    发明人： Katsumi Kouno ,  Hidetoshi Sakai ,  Kaoru Shimizu ,  Takahide Kawai

    IPC分类号： A61J1/10 ,  A61J1/14 ,  A61J1/20 ,  B65D75/56 ,  B65D75/58 ,  B65D81/32

    摘要： A multi-cell container includes a bag of substantially flat shape made of flexible film, a partition wall as a separable seal welding opposite inner surfaces of the bag and dividing an inner space of the bag into a plurality of compartments and an inlet-outlet port located at a periphery of the bag so as to be opened to one of the plurality of compartments for introduction and/or discharge of liquid. The partition wall has a horizontal section extending in a direction along the bottom of the bag and a vertical section bent therefrom and extending to the topside of the bag. A first larger volume compartment is formed on one side of the partition wall adjacent the bag bottom and a second smaller volume compartment is formed on the other side of the partition wall. The inlet-outlet port is opened to the first chamber.