公开(公告)号：US20160324813A1

公开(公告)日：2016-11-10

申请号：US15216225

申请日：2016-07-21

申请人： EA Pharma Co., Ltd. ,  Niigata University

发明人： Akihiko SAITO ,  Nobumasa AOKI ,  Yoshihisa HORI ,  Shoji KUWAHARA ,  Michihiro HOSOJIMA ,  Hiroshi IWATA ,  Saori MATSUDA

IPC分类号： A61K31/198 ,  B65D81/32 ,  A61K31/436 ,  A61K38/14 ,  A61K38/12 ,  A61K33/24

摘要： The present invention includes cilastatin or a pharmaceutically acceptable salt thereof as an active component and a suppressant for renal impairment or inner ear disorders, induced via megalin by at least one megalin ligand which is selected from the group consisting of polymyxins, aminoglycoside antibiotics, glycopeptide antibiotics, cisplatin, and pharmaceutically acceptable salts thereof

摘要翻译： 本发明包括西司他丁或其药学上可接受的盐作为活性成分，以及通过至少一种巨蛋白配体通过巨蛋白诱导的肾损伤或内耳障碍的抑制剂，所述巨蛋白配体选自多粘菌素，氨基糖苷类抗生素，糖肽抗生素 ，顺铂及其药学上可接受的盐

公开(公告)号：US20230366890A1

公开(公告)日：2023-11-16

申请号：US18030714

申请日：2021-10-07

申请人： Niigata University ,  Denka Company Limited

发明人： Akihiko SAITO ,  Michihiro HOSOJIMA ,  Hideyuki KABASAWA ,  Nobumasa AOKI ,  Kei NAGANO ,  Sakari SEKINE ,  Keisuke MUNEKATA

IPC分类号： G01N33/68

CPC分类号： G01N33/6854 ,  G01N2800/52 ,  G01N2800/50 ,  G01N2333/085 ,  G01N2800/26

摘要： The present invention provides a method of assisting a determination of whether a subject is susceptible to infection by norovirus or whether a subject is susceptible to post-infection worsening, wherein this method contains a step of measuring the concentration of IgG antibody that is present in a sample originating from within the oral cavity of the subject.