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公开(公告)号：US12102696B2
公开(公告)日：2024-10-01
申请号：US17467110
申请日：2021-09-03
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , Shaun Loveless , Allan Casciola
CPC分类号： A61K51/0472 , A61K51/083
摘要： The present disclosure relates to methods to create a robust procedure capable of supplying commercial quantities of a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients.
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公开(公告)号：US20240025579A1
公开(公告)日：2024-01-25
申请号：US18479479
申请日：2023-10-02
申请人： Curium US LLC
摘要： Production systems for producing a radioactive drug product include a hot cell having a radiation isolating shielding and a dispensing unit positioned within the hot cell. The dispensing unit includes a manipulator arm for manipulating a closure component of a vial. The system further includes a pneumatic line extending from the manipulator arm and through the radiation isolating shielding to a location outside of the hot cell and a pressure sensor connected to the pneumatic line and positioned outside of the radiation isolating shielding. The pressure sensor is operable to detect air pressure within the pneumatic line.
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公开(公告)号：US11851221B2
公开(公告)日：2023-12-26
申请号：US18088007
申请日：2022-12-23
申请人： Curium US LLC
摘要： Production systems for producing a radioactive drug product include a hot cell having a radiation isolating shielding and a dispensing unit positioned within the hot cell. The dispensing unit includes a manipulator arm for manipulating a closure component of a vial. The system further includes a pneumatic line extending from the manipulator arm and through the radiation isolating shielding to a location outside of the hot cell and a pressure sensor connected to the pneumatic line and positioned outside of the radiation isolating shielding. The pressure sensor is operable to detect air pressure within the pneumatic line.
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公开(公告)号：US11679979B2
公开(公告)日：2023-06-20
申请号：US16405703
申请日：2019-05-07
申请人： Curium US LLC
发明人： Luis Antonio M. M. Barbosa , Sven V. Gerritsen , Martinus J. A. Schackmann , Paul A. Gronland , Brian Hierholzer
CPC分类号： C01B23/0063
摘要： Methods and systems for producing Xenon-133 are disclosed. A method for producing Xenon-133 includes collecting an off gas from a Molybdenum-99 production process in a storage tank. The off gas includes Xenon-133 and Krypton-85. The method further includes selectively adsorbing Xenon-133 from the off gas onto a charcoal column assembly such that Xenon-133 is selectively adsorbed onto the charcoal column assembly relative to Krypton-85. The method further includes desorbing the Xenon-133 from the charcoal column assembly by heating the charcoal column assembly, and condensing the Xenon-133 within a coil assembly.
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公开(公告)号：US11186389B2
公开(公告)日：2021-11-30
申请号：US16433181
申请日：2019-06-06
申请人： Curium US LLC
发明人： Sumit Verma , Kevin B. Graves
摘要： A unit dose container production system (10) is disclosed where a unit dose container (130) is evacuated and thereafter loaded with a radioactive fluid while remaining at a single location. In this regard, the production system (10) uses a first conveyor (12) to sequentially load unit dose containers (130) into an empty container receptacle (24) of a second conveyor (20) at a first location (90). The second conveyor (20) may be operated to dispose a container receptacle (24) at each of the first location (90), a second location (100), and a third location (110). A unit dose container (130) at the second location (100) is evacuated and thereafter loaded with a radioactive fluid, and is thereafter moved to a third location (110) by the second conveyor (20). The unit dose container (130) is removed from the second conveyor (20) at the third location (110), and thereafter the radioactivity content of a unit dose container (130) may be determined, such as at an ionization chamber or the like.
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公开(公告)号：US10928545B2
公开(公告)日：2021-02-23
申请号：US16406680
申请日：2019-05-08
申请人： Curium US LLC
发明人： Bart Schaap , Sterling Marshall
摘要： The present disclosure provides a gamma-ray attenuator and a gamma-ray shield for use in gamma-ray spectroscopy. The gamma-ray attenuator is a sleeve comprising a wall, a distal end, and a proximal end. The distal end of the sleeve is closed, and the proximal end of the sleeve forms an opening. A copper insert, a tin insert and a tungsten insert are installed in the sleeve such that the copper insert is adjacent to the distal end and the tungsten insert is closest to the proximal end. The sleeve is comprised of one or more materials that do not substantially attenuate gamma-rays. The open end of the sleeve fits over a tungsten safe that is operable to hold a radionuclide sample. When fitted together, a gamma-ray attenuator and a safe comprise a gamma-ray shield.
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公开(公告)号：US10201787B2
公开(公告)日：2019-02-12
申请号：US15288858
申请日：2016-10-07
申请人： Curium US LLC
发明人： Mark D. Worley , Michael R. Mahoney
摘要： A slurry dispensing system is disclosed. A peristaltic pump may direct a flow of slurry out of a horizontal mixer to a slurry dispenser. This slurry dispenser may be operated on a programmed manner by a controller to dispense slurry into a container. Both a bypass valve and a dispensing valve of the slurry dispenser may be opened/closed on a programmed basis by the controller to deliver slurry to a container, such as a glass column. Slurry may be intermittently directed into a metering chamber of the slurry dispenser, while the remainder of the slurry being directed into the slurry dispenser may be recirculated back to the horizontal mixer.
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公开(公告)号：US20240331889A1
公开(公告)日：2024-10-03
申请号：US18733537
申请日：2024-06-04
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230420152A1
公开(公告)日：2023-12-28
申请号：US18238951
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0094 , A61K51/0482 , G21G4/08 , C01G3/003
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230411032A1
公开(公告)日：2023-12-21
申请号：US18238966
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , C01G3/003 , A61K51/0482 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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