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公开(公告)号：US12102696B2
公开(公告)日：2024-10-01
申请号：US17467110
申请日：2021-09-03
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , Shaun Loveless , Allan Casciola
CPC分类号： A61K51/0472 , A61K51/083
摘要： The present disclosure relates to methods to create a robust procedure capable of supplying commercial quantities of a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients.
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公开(公告)号：US11798701B2
公开(公告)日：2023-10-24
申请号：US17993186
申请日：2022-11-23
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230317308A1
公开(公告)日：2023-10-05
申请号：US18043250
申请日：2021-08-25
申请人： Curium US LLC
发明人： Lauren Radford , Valery Shahanov , Alex Micka
CPC分类号： G21F5/015 , G21G1/0005
摘要： A closure includes a body extending longitudinally along a central longitudinal axis from a first, upper surface to a second, lower surface. The body defines a cavity extending into the body from the lower surface to a third, interior surface. The cavity is sized and shaped to receive a portion of a container therein. The body includes a shroud extending from the interior surface to the lower surface, and a container insert depending from the interior surface and positioned within the cavity. The container insert is sized and shaped to fit within an opening of the container. The body further includes an outlet flow path in fluid communication with the cavity, and at least one inlet flow path in fluid communication with the cavity. The at least one inlet flow path is positioned and oriented to generate a vortex gas flow within the container when connected thereto.
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公开(公告)号：US20220406483A1
公开(公告)日：2022-12-22
申请号：US17894874
申请日：2022-08-24
申请人： CURIUM US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20240331889A1
公开(公告)日：2024-10-03
申请号：US18733537
申请日：2024-06-04
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230420152A1
公开(公告)日：2023-12-28
申请号：US18238951
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0094 , A61K51/0482 , G21G4/08 , C01G3/003
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230411032A1
公开(公告)日：2023-12-21
申请号：US18238966
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , C01G3/003 , A61K51/0482 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230402199A1
公开(公告)日：2023-12-14
申请号：US18238972
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , A61K51/0482 , G21G4/08 , C01G3/003 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20220064015A1
公开(公告)日：2022-03-03
申请号：US17466443
申请日：2021-09-03
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US11978569B2
公开(公告)日：2024-05-07
申请号：US18238966
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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